Search Results

Involvement of microRNAs in epigallocatechin gallate-mediated UVB protection in human dermal fibroblasts

The green tea polyphenol epigallocatechin-3-gallate (EGCG) is a potent anti-oxidant and anticancer compound. Recently, EGCG-mediated UVB photoprotection was reported in normal human dermal fibroblasts (NHDFs); however, the molecular mechanism...

Authors: An IS, An S, Park S, Lee SN, Bae S.

Intrinsic multipotential mesenchymal stromal cell activity in gelatinous Heberden's nodes in osteoarthritis at clinical presentation

INTRODUCTION: Gelatinous Heberden's nodes (HNs), also termed synovial cysts, are a common form of generalised osteoarthritis (OA). We sought to determine if HN cases at clinical presentation contained multipotential stromal cells (MSCs), and to...

Authors: Baboolal TG, Boxall SA, Churchman SM, Buckley CT, Jones E, McGonagle D.

CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo

BACKGROUND: Chemotherapy in cancer patients can be associated with serious short- and long-term adverse neurological effects, such as leukoencephalopathy and cognitive impairment, even when therapy is delivered systemically. The underlying...

Authors: Dietrich J, Han R, Yang Y, Mayer-Pröschel M, Noble M.

SST Peer Reviewed

Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes

Drug-induced liver injury (DILI) is a major cause of failed drug development, withdrawal and restricted usage. Therefore screening assays which aid selection of candidate drugs with reduced propensity to cause DILI are required. We have investigated...

Authors: Garside H, Marcoe KF, Chesnut-Speelman J, Foster AJ, Muthas D, Kenna JG, Warrior U, Bowes J,...

Hellebrin and its aglycone form hellebrigenin display similar in vitro growth inhibitory effects in cancer cells and binding profiles to the alpha subunits of the Na+/K+-ATPase

BACKGROUND: Surface-expressed Na+/K+-ATPase (NaK) has been suggested to function as a non-canonical cardiotonic steroid-binding receptor that activates multiple signaling cascades, especially in cancer cells. By contrast, the current study...

Authors: Moreno Y Banuls L1, Katz A, Miklos W, Cimmino A, Tal DM, Ainbinder E, Zehl M, Urban E, Evidente A,...

Aneuploidy is permissive for hepatocyte-like cell differentiation from human induced pluripotent stem cells

BACKGROUND: The characterization of induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) routinely includes analyses of chromosomal integrity. The belief is that pluripotent stem cells best suited to the generation of...

Authors: Noto FK, Determan MR, Cai J, Cayo MA, Mallanna SK, Duncan SA

Bisphenol A diglycidyl ether induces adipogenic differentiation of multipotent stromal stem cells through a peroxisome proliferator-activated receptor gamma-independent mechanism

BACKGROUND: Bisphenol A (BPA) and bisphenol A diglycidyl ether (BADGE), used in manufacturing coatings and resins, leach from packaging materials into food. Numerous studies suggested that BPA and BADGE may have adverse effects on human health,...

Authors: Chamorro-García R, Kirchner S, Li X, Janesick A, Casey SC, Chow C, Blumberg B.

Adenosine A(2A) receptors promote collagen production by a Fli1- and CTGF-mediated mechanism

INTRODUCTION: Adenosine, acting through the A(2A) receptor, promotes tissue matrix production in the skin and the liver and induces the development of dermal fibrosis and cirrhosis in murine models. Since expression of A(2A) receptors is increased...

Authors: Chan ES, Liu H, Fernandez P, Luna A, Perez-Aso M, Bujor AM, Trojanowska M, Cronstein BN.

Hepatocytes buried in the cirrhotic livers of patients with biliary atresia proliferate and function in the livers of urokinase-type plasminogen activator-NOG mice.

The pathogenesis of biliary atresia (BA), which leads to end-stage cirrhosis in most patients, has been thought to inflame and obstruct the intrahepatic and extrahepatic bile ducts. BA is not believed to be caused by abnormalities in parenchymal...

Authors: Suemizu H, Nakamura K, Kawai K, Higuchi Y, Kasahara M, Fujimoto J, Tanoue A, Nakamura M.

A simplified method for the generation of human osteoclasts in vitro

Osteoclasts are large, multinucleated cells responsible for the resorption of mineralized bone matrix. These cells are critical players in the bone turnover involved in bone homeostasis. Osteoclast activity is connected to the establishment and...

Authors: Cody JJ, Rivera AA, Liu J, Liu JM, Douglas JT, Feng X.

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