Search Results

Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system

Multiple sclerosis is a neuroinflammatory disease associated with axonal degeneration. The neuronally expressed, proton-gated acid-sensing ion channel-1 (ASIC1) is permeable to Na(+) and Ca(2+), and excessive accumulation of these ions is associated...

Authors: Friese MA, Craner MJ, Etzensperger R, Vergo S, Wemmie JA, Welsh MJ, Vincent A, Fugger L

Identification of a novel p53-dependent activation pathway of STAT1 by antitumour genotoxic agents

Chemotherapeutic drugs such as fludarabine(*), doxorubicin or cisplatin are very potent activators of the anti-oncogene p53. Convergent studies suggest that p53 and STAT1 (signal transducer and activator of transcription 1) cooperate in the induction...

Authors: Youlyouz-Marfak I, Gachard N, Le Clorennec C, Najjar I, Baran-Marszak F, Reminieras L, May E,...

Differential Activities of Glucocorticoid-induced Leucine Zipper Protein Isoforms

Glucocorticoid-induced leucine zipper protein (GILZ) is expressed in both epithelial and immune tissues and modulates a variety of cellular functions, including proliferation and epithelial sodium channel (ENaC) activity. A number of reports have...

Authors: Soundararajan R, Wang J, Melters DP, Pearce D

5' Trans-Splicing Repair of the PLEC1 Gene

The efficient treatment of hereditary disorders, especially of those caused by dominant-negative mutations still remains an obstacle to be overcome. Allele specificity is a critical aspect that must be addressed by silencing therapies such as small...

Authors: Wally V, Klausegger A, Koller U, Lochmueller H, Krause S, Wiche G, Mitchell LG, Hintner H, Bauer JW

Rac1 and Rac2 differentially regulate actin free barbed end formation downstream of the fMLP receptor

Actin assembly at the leading edge of migrating cells depends on the availability of high-affinity free barbed ends (FBE) that drive actin filament elongation and subsequent membrane protrusion. We investigated the specific mechanisms through which...

Authors: Sun CX, Magalhaes MA, Glogauer M

Involvement of Rab13 and JRAB/MICAL-L2 in epithelial cell scattering

Epithelial cell scattering recapitulates the first steps of carcinoma invasion/metastasis. While the balance between cell-cell adhesive activity and cell motility ultimately determines this process, its molecular mechanisms remain unclear. Adherence...

Authors: Kanda I, Nishimura N, Nakatsuji H, Yamamura R, Nakanishi H, Sasaki T

KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions

Cerebral cavernous malformation (CCM), a disease associated with defective endothelial junctions, result from autosomal dominant CCM1 mutations that cause loss of KRIT-1 protein function, though how the loss of KRIT-1 leads to CCM is obscure. KRIT-1...

Authors: Glading A, Han J, Stockton RA, Ginsberg MH

SST Peer Reviewed

Differential expression of D-type cyclins in HaCaT keratinocytes and in psoriasis

In this study, we show that the G(0)-G(1)/S phase of HaCaT keratinocyte cell cycle is characterized by D1-type cyclin expression, whereas during the repeated rapid turnover of highly proliferating cells, the expression of cyclins D2 and D3 dominates....

Authors: Belso N, Szell M, Pivarcsi A, Kis K, Kormos B, Kenderessy AS, Dobozy A, Kemeny L, Bata-Csorgo Z

Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis

A recently discovered phosphatidylinositol monophosphate, phosphatidylinositol 5-phosphate (PtdIns-5-P), plays an important role in nuclear signaling by influencing p53-dependent apoptosis. It interacts with a plant homeodomain finger of inhibitor of...

Authors: Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW

Activation of double-stranded RNA-activated protein kinase by mild impairment of oxidative metabolism in neurons

Thiamine (vitamin B1) deficiency (TD) causes mild and chronic impairment of oxidative metabolism and induces neuronal death in specific brain regions. The mechanisms underlying TD-induced cell death, however, remain unclear. The double-stranded...

Authors: Wang X, Fan Z, Wang B, Luo J, Ke ZJ

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