Search Results

Transcripts of unknown function in multiple-signaling pathways involved in human stem cell differentiation

Mammalian transcriptome analysis has uncovered tens of thousands of novel transcripts of unknown function (TUFs). Classical and recent examples suggest that the majority of TUFs may underlie vital intracellular functions as non-coding RNAs because of...

Authors: Kikuchi K, Fukuda M, Ito T, Inoue M, Yokoi T, Chiku S, Mitsuyama T, Asai K, Hirose T, Aizawa Y.

Adipocytes as a source of increased circulating levels of nicotinamide phosphoribosyltransferase/visfatin in active acromegaly

BACKGROUND: Nicotinamide phosphoribosyltransferase (NAMPT)/visfatin is a widely expressed protein with various effects on glucose and lipid metabolism, cell survival, and inflammation. AIM: We hypothesized that NAMPT was related to metabolic...

Authors: Olarescu NC, Ueland T, Lekva T, Dahl TB, Halvorsen B, Aukrust P, Bollerslev J.

SST Peer Reviewed

Rab5 is a novel regulator of mast cell secretory granules: impact on size, cargo, and exocytosis.

Secretion of inflammatory mediators prestored in mast cells secretory granules (SGs) enhances immune responses such as in allergy and host defense. However, the mechanisms underlying the biogenesis of the SGs remain largely unresolved. By combining...

Authors: Azouz NP1, Zur N, Efergan A, Ohbayashi N, Fukuda M, Amihai D, Hammel I, Rothenberg ME,...

Impact of metabolic regulators on the expression of the obesity associated genes FTO and NAMPT in human preadipocytes and adipocytes.

BACKGROUND: FTO and NAMPT/PBEF/visfatin are thought to play a role in obesity but their transcriptional regulation in adipocytes is not fully understood. In this study, we evaluated the transcriptional regulation of FTO and NAMPT in preadipocytes...

Authors: Friebe D, Löffler D, Schönberg M, Bernhard F, Büttner P, Landgraf K, Kiess W, Körner A.

SST Peer Reviewed

Toll-like receptor 4 mediates endothelial cell activation through NF-?B but is not associated with endothelial dysfunction in patients with rheumatoid arthritis

OBJECTIVE: To investigate the effects of TLR4 antagonism on human endothelial cells activation and cytokine expression, and whether the Asp299Gly TLR4 polymorphism is associated with better endothelial function in patients with rheumatoid...

Authors: Menghini R, Campia U, Tesauro M, Marino A, Rovella V, Rodia G, Schinzari F, Tolusso B, di Daniele N,...

The Secretome of Human Bronchial Epithelial Cells Exposed to Fine Atmospheric Particles Induces Fibroblast Proliferation

Chronic exposure to particulate pollution is suspected to exacerbate inflammatory respiratory diseases such as asthma characterized by an airway remodelling involving fibrosis. Our study aims to investigate whether the secretome from human bronchial...

Authors: Boublil L, Martinon L, Baeza-Squiban A

SST Peer Reviewed

In vitro response of Human Pre-osteoclasts to low intensity Laser irradiation

In vitro and in vivo studies have demonstrated that low intensity laser irradiation stimulates growth and cell differentiation of precursor cells, promoting dental movement and alveolar bone remodeling. But the information about the effect of laser...

Authors: Domíngueza A, Bayonab G, Casasb A

SST Peer Reviewed

Donepezil can improve ischemic muscle atrophy by activating angiomyogenic properties of satellite cells

BACKGROUND: Saving more limbs of patients with peripheral arterial disease (PAD) from amputation by accelerating angiogenesis in affected limbs has been anticipated for years. We hypothesized that an anti-Alzheimer drug, donepezil (DPZ), can...

Authors: Noguchi T, Kakinuma Y, Arikawa M, Okazaki K, Hoshino E, Iiyama T, Kubo T, Kitaoka H, Doi Y, Sato T

Effects of 9cis,11trans and 10trans,12cis CLA on osteoclast formation and activity from human CD14+ monocytes

BACKGROUND: Mixed CLA isomers variably affect bone resorption in animals and decrease osteoclast formation and activity in murine osteoclasts. These variable effects may be due to the different isomers present in commercial preparations of CLA,...

Authors: Platt I, El-Sohemy A

SST Peer Reviewed

The Chemical and Physical Properties of Poly(e-caprolactone) Scaffolds Functionalised with Poly(vinyl phosphonic acid-co-acrylic acid).

There is a clinical need for a synthetic alternative to bone graft substitute (BGS) derived from demineralised bone matrix. We report the electrospinning of Poly(e-caprolactone) (PCL) to form a 3-dimensional scaffold for use as a synthetic BGS....

Authors: Bassi AK, Gough JE, Zakikhani M, Downes S.

SST Peer Reviewed

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Transcripts of unknown function in multiple-signaling pathways involved in human stem cell differentiation

Adipocytes as a source of increased circulating levels of nicotinamide phosphoribosyltransferase/visfatin in active acromegaly

Rab5 is a novel regulator of mast cell secretory granules: impact on size, cargo, and exocytosis.

Impact of metabolic regulators on the expression of the obesity associated genes FTO and NAMPT in human preadipocytes and adipocytes.

Toll-like receptor 4 mediates endothelial cell activation through NF-?B but is not associated with endothelial dysfunction in patients with rheumatoid arthritis

The Secretome of Human Bronchial Epithelial Cells Exposed to Fine Atmospheric Particles Induces Fibroblast Proliferation

In vitro response of Human Pre-osteoclasts to low intensity Laser irradiation

Donepezil can improve ischemic muscle atrophy by activating angiomyogenic properties of satellite cells

Effects of 9cis,11trans and 10trans,12cis CLA on osteoclast formation and activity from human CD14+ monocytes

The Chemical and Physical Properties of Poly(e-caprolactone) Scaffolds Functionalised with Poly(vinyl phosphonic acid-co-acrylic acid).