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Type Igamma PIP Kinase Is a Novel Uropod Component that Regulates Rear Retraction during Neutrophil Chemotaxis

Cell polarization is necessary for directed migration and leukocyte recruitment to inflamed tissues. Recent progress has been made in defining the molecular mechanisms that regulate chemoattractant-induced cell polarity during chemotaxis, including...

Authors: Lokuta MA, Senetar MA, Bennin DA, Nuzzi PA, Chan KT, Ott VL, Huttenlocher A

A role for ATP-citrate lyase, malic enzyme and pyruvate/citrate cycling in glucose-induced insulin secretion

In pancreatic ss-cells, metabolic coupling factors generated during glucose metabolism and pyruvate cycling, through anaplerosis/cataplerosis processes, contribute to the regulation of insulin secretion. Pyruvate/citrate cycling across the...

Authors: Guay C, Madiraju SR, Aumais A, Joly E, Prentki M

Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1

gamma-Secretase is involved in the production of amyloid beta-peptide, which is the principal component of amyloid plaques in the brains of patients with Alzheimer disease. gamma-Secretase is a complex composed of presenilin (PS), nicastrin, anterior...

Authors: Kaether C, Scheuermann J, Fassler M, Zilow S, Shirotani K, Valkova C, Novak B, Kacmar S, Steiner H,...

The C terminus of the synovial sarcoma-associated SSX proteins interacts with the LIM homeobox protein LHX4

As a result of the synovial sarcoma-associated t(X;18) translocation, the SS18 gene on chromosome 18 is fused to either one of the three closely related SSX genes on the X chromosome. The SS18 protein is thought to act as a transcriptional...

Authors: de Bruijn DR, van Dijk AH, Willemse MP, van Kessel AG

Antizyme, a mediator of ubiquitin-independent proteasomal degradation and its inhibitor localize to centrosomes and modulate centriole amplification

The potential tumor suppressor antizyme and its endogenous inhibitor (antizyme inhibitor, AZI) have been implicated in the ubiquitin-independent proteasomal degradation of proteins involved in cell proliferation as well as in the regulation of...

Authors: Mangold U, Hayakawa H, Coughlin M, Münger K, Zetter BR

Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling

The death of midbrain dopaminergic neurons in sporadic Parkinson's disease (PD) is of unknown etiology, but may involve altered growth factor signaling. The present study showed that leptin, a centrally acting hormone secreted by adipocytes, rescued...

Authors: Weng Z, Signore AP, Gao Y, Wang S, Zhang F, Hastings T, Yin XM, Chen J

Nucleic acid therapeutics for hematologic malignancies--theoretical considerations

Our work is motivated by the belief that RNA targeted gene silencing agents can be developed into effective drugs for treating hematologic malignancies. In many experimental systems, antisense nucleic acids of various composition, including antisense...

Authors: Opalinska JB, Kalota A, Chattopadhyaya J, Damha M, Gewirtz AM

Efficient nucleofection of primary human B cells and B-CLL cells induces apoptosis, which depends on the microenvironment and on the structure of transfected nucleic acids

Accumulation of neoplastic cells in B-cell chronic lymphocytic leukemia (B-CLL) is thought to be due to intrinsic defects in the apoptotic machinery of the leukemic cells or to an altered, survival-stimulating microenvironment in vivo. Despite their...

Authors: Seiffert M, Stilgenbauer S, Döhner H, Lichter P

SST Peer Reviewed

Dicarbonyl stress and apoptosis of vascular cells: prevention by alphaB-crystallin

Methylglyoxal (MGO) is an alpha-dicarbonyl compound produced from triose phosphate intermediates of glycolysis. It reacts rapidly with proteins to produce advanced glycation products. We have studied the effect of MGO modification of fibronectin on...

Authors: Nagaraj RH, Oya-Ito T, Bhat M, Liu B

Mitofusin 2 triggers vascular smooth muscle cell apoptosis via mitochondrial death pathway

Previous studies have shown that mitofusin 2 (Mfn-2) (or hyperplasia suppressor gene [HSG]) inhibits vascular smooth muscle cell (VSMC) proliferation. Here, we demonstrate that Mfn-2 is a primary determinant of VSMC apoptosis. First, oxidative stress...

Authors: Guo X, Chen KH, Guo Y, Liao H, Tang J, Xiao RP

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