Search Results

Density gradient centrifugation compromises bone marrow mononuclear cell yield.

Bone marrow mononuclear cells (BMNCs) are widely used in regenerative medicine, but recent data suggests that the isolation of BMNCs by commonly used Ficoll-Paque density gradient centrifugation (DGC) causes significant cell loss and influences graft...

Authors: Pösel C, Möller K, Fröhlich W, Schulz I, Boltze J, Wagner DC.

SST Peer Reviewed

Betacellulin inhibits osteogenic differentiation and stimulates proliferation through HIF-1alpha

Cellular signaling via epidermal growth factor (EGF) and EGF-like ligands can determine cell fate and behavior. Osteoblasts, which are responsible for forming and mineralizing osteoid, express EGF receptors and alter rates of proliferation and...

Authors: Genetos DC, Rao RR, Vidal MA.

Antiangiogenic plasma activity in patients with systemic sclerosis.

OBJECTIVE: Systemic sclerosis (SSc; scleroderma) is a systemic connective tissue disease with an extensive vascular component that includes aberrant microvasculature and impaired wound healing. The aim of this study was to investigate the...

Authors: Mulligan-Kehoe MJ, Drinane MC, Mollmark J, Casciola-Rosen L, Hummers LK, Hall A, Rosen A, Wigley FM,...

Intrinsic regulation of hemangioma involution by platelet-derived growth factor

Infantile hemangioma is a vascular tumor that exhibits a unique natural cycle of rapid growth followed by involution. Previously, we have shown that hemangiomas arise from CD133+ stem cells that differentiate into endothelial cells when implanted in...

Authors: Roach EE, Chakrabarti R, Park NI, Keats EC, Yip J, Chan NG, Khan ZA.

Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELM alpha) recruits bone marrow-derived cells to the murine pulmonary vasculature

BACKGROUND: Pulmonary hypertension (PH) is a disease of multiple etiologies with several common pathological features, including inflammation and pulmonary vascular remodeling. Recent evidence has suggested a potential role for the recruitment of...

Authors: Angelini DJ1, Su Q, Kolosova IA, Fan C, Skinner JT, Yamaji-Kegan K, Collector M, Sharkis SJ, Johns...

A novel serum-free medium for the expansion of human mesenchymal stem cells.

INTRODUCTION: Human multipotent mesenchymal stem cell (MSC) therapies are being tested clinically for a variety of disorders, including Crohn's disease, multiple sclerosis, graft-versus-host disease, type 1 diabetes, bone fractures, and cartilage...

Authors: Chase LG, Lakshmipathy U, Solchaga LA, Rao MS, Vemuri MC.

SST Peer Reviewed

Macrophage-associated mesenchymal stem cells assume an activated, migratory, pro-inflammatory phenotype with increased IL-6 and CXCL10 secretion

Mesenchymal stem cells (MSCs) exhibit tropism for sites of tissue injury and tumors. However, the influence of the microenvironment on MSC phenotype and localization remains incompletely characterized. In this study, we begin to define a...

Authors: Anton K, Banerjee D, Glod J.

Regulation of lymphatic-blood vessel separation by endothelial Rac1

Sprouting angiogenesis and lymphatic-blood vessel segregation both involve the migration of endothelial cells, but the precise migratory molecules that govern the decision of blood vascular endothelial cells to segregate into lymphatic vasculature...

Authors: D\'Amico G, Jones DT, Nye E, Sapienza K, Ramjuan AR, Reynolds LE, Robinson SD, Kostourou V, Martinez...

Small-diameter human vessel wall engineered from bone marrow-derived mesenchymal stem cells (hMSCs).

Using biodegradable scaffold and a biomimetic perfusion system, our lab has successfully engineered small-diameter vessel grafts using endothelial cells (ECs) and smooth muscle cells (SMCs) obtained from vessels in various species. However,...

Authors: Gong Z, Niklason LE.

SST Peer Reviewed

A new concept underlying stem cell lineage skewing that explains the detrimental effects of thiazolidinediones on bone

Bone-marrow adipogenesis is an aging-related phenomenon and is correlated with osteoporosis. The latter is a prevalent bone disease in the elderly leading to increased fracture risk and mortality. It is widely hypothesized that the underlying...

Authors: Bruedigam C, Eijken M, Koedam M, van de Peppel J, Drabek K, Chiba H, van Leeuwen JP.

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Topic

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Density gradient centrifugation compromises bone marrow mononuclear cell yield.

Betacellulin inhibits osteogenic differentiation and stimulates proliferation through HIF-1alpha

Antiangiogenic plasma activity in patients with systemic sclerosis.

Intrinsic regulation of hemangioma involution by platelet-derived growth factor

Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELM alpha) recruits bone marrow-derived cells to the murine pulmonary vasculature

A novel serum-free medium for the expansion of human mesenchymal stem cells.

Macrophage-associated mesenchymal stem cells assume an activated, migratory, pro-inflammatory phenotype with increased IL-6 and CXCL10 secretion

Regulation of lymphatic-blood vessel separation by endothelial Rac1

Small-diameter human vessel wall engineered from bone marrow-derived mesenchymal stem cells (hMSCs).

A new concept underlying stem cell lineage skewing that explains the detrimental effects of thiazolidinediones on bone