Search Results

Hippocampal Neuron Protecting Effect of Propofol Against Hypoxia/Reoxygenation via Inducing Nerve Growth Factor

Propofol, an intravenous anesthetic agent, exhibits neuroprotective effects against cerebral ischemia–reperfusion injury. Here, we used a model of Hypoxia/Re-Oxygenation (H/R) injury to examine the hippocampal neuroprotective effect of propofol, and...

Authors: Feng YN, Shi Q, Ma H, Fang J

SST Peer Reviewed

The activin A-follistatin system: potent regulator of human extracellular matrix mineralization

Bone quality is an important determinant of osteoporosis, and proper osteoblast differentiation plays an important role in the control and maintenance of bone quality. We investigated the impact of activin signaling on human osteoblast...

Authors: Eijken M, Swagemakers S, Koedam M, Steenbergen C, Derkx P, Uitterlinden AG, van der Spek PJ, Visser...

Age-associated changes in the differentiation potentials of human circulating hematopoietic progenitors to T- or NK-lineage cells

Age-associated changes of T and NK cell (T/NK) potential of human hematopoietic stem cells are unknown. In this study, we enumerate and characterize T/NK precursors among CD34(+)Lin(-) cell populations circulating in normal human adult peripheral...

Authors: Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Imai K, Hayashi T, Nakachi K, Young LF, Moore MA, van den...

SST Peer Reviewed

Development of a serum-free system to expand dental-derived stem cells: PDLSCs and SHEDs

Recently, extracted teeth have been identified as a viable source of stem cells for tissue regenerative approaches. Current expansion of these cells requires incorporation of animal sera; yet, a fundamental issue underlying cell cultivation methods...

Authors: Tarle SA, Shi S, Kaigler D.

NFAT and CREB regulate Kaposi's sarcoma-associated herpesvirus-induced cyclooxygenase 2 (COX-2)

However, the precise regulatory mechanisms involved in COX-2 induction during KSHV infection have never been explored. Here, we identified cis-acting elements involved in the transcriptional regulation of COX-2 upon KSHV de novo infection. Promoter...

Authors: Sharma-Walia N, George Paul A, Patel K, Chandran K, Ahmad W, Chandran B

Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing\\\'s sarcoma family of tumours by activating the FGFR1-PI3K-Rac1 pathway

BACKGROUND: Ewing's sarcoma family of tumours (ESFT) is a malignant small round-cell tumour of the bone and soft tissues. It is characterised by a strong tendency to invade and form metastases. The microenvironment of the bone marrow is a large...

Authors: Kamura S, Matsumoto Y, Fukushi JI, Fujiwara T, Iida K, Okada Y, Iwamoto Y.

Airway epithelium stimulates smooth muscle proliferation

Communication between the airway epithelium and stroma is evident during embryogenesis, and both epithelial shedding and increased smooth muscle proliferation are features of airway remodeling. Hence, we hypothesized that after injury the airway...

Authors: Malavia NK, Raub CB, Mahon SB, Brenner M, Panettieri RA Jr, George SC.

SST Peer Reviewed

Suppression of endothelial cell activity by inhibition of TNFa

INTRODUCTION: TNFa is a proinflammatory cytokine that plays a central role in the pathogenesis of rheumatoid arthritis (RA). We investigated the effects of certolizumab pegol, a TNFa blocker, on endothelial cell function and angiogenesis....

Authors: Shu Q, Amin MA, Ruth JH, Campbell PL, Koch AE.

Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow

Mesenchymal stem cells (MSCs) are defined as cells that undergo sustained in vitro growth and can give rise to multiple mesenchymal lineages. Because MSCs have only been isolated from tissue in culture, the equivalent cells have not been identified...

Authors: Morikawa S, Mabuchi Y, Kubota Y, Nagai Y, Niibe K, Hiratsu E, Suzuki S, Miyauchi-Hara C, Nagoshi N,...

Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase

BACKGROUND: Human cord blood (hCB) is the main source of hematopoietic stem and progenitor cells (HSCs/PCs) for transplantation. Efforts to overcome relative shortages of HSCs/PCs have led to technologies to expand HSCs/PCs ex vivo. However,...

Authors: Nishino T, Wang C, Mochizuki-Kashio M, Osawa M, Nakauchi H, Iwama A.

Data Type

Category

Research Area

Platform

Topic

Species

Characteristic

Format

Origin

Hippocampal Neuron Protecting Effect of Propofol Against Hypoxia/Reoxygenation via Inducing Nerve Growth Factor

The activin A-follistatin system: potent regulator of human extracellular matrix mineralization

Age-associated changes in the differentiation potentials of human circulating hematopoietic progenitors to T- or NK-lineage cells

Development of a serum-free system to expand dental-derived stem cells: PDLSCs and SHEDs

NFAT and CREB regulate Kaposi's sarcoma-associated herpesvirus-induced cyclooxygenase 2 (COX-2)

Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing\\\'s sarcoma family of tumours by activating the FGFR1-PI3K-Rac1 pathway

Airway epithelium stimulates smooth muscle proliferation

Suppression of endothelial cell activity by inhibition of TNFa

Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow

Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase