Search Results

Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

Targeted genome editing technologies have enabled a broad range of research and medical applications. The Cas9 nuclease from the microbial CRISPR-Cas system is targeted to specific genomic loci by a 20 nt guide sequence, which can tolerate certain...

Authors: Ran FA, Hsu PD, Lin CY, Gootenberg JS, Konermann S, Trevino AE, Scott DA, Inoue A, Matoba S, Zhang...

SST Peer Reviewed

Low FasL levels promote proliferation of human bone marrow-derived mesenchymal stem cells, higher levels inhibit their differentiation into adipocytes.

Mesenchymal stem cells (MSCs) are multipotent progenitor cells that can differentiate into several cell types. Bone marrow (BM)-MSCs mainly differentiate into osteoblasts or adipocytes. MSC interactions with their microenvironment directly affect...

Authors: Rippo MR, Babini L, Prattichizzo F, Graciotti L, Fulgenzi G, Tomassoni Ardori F, Olivieri F,...

Are Carbon Nanotube Microelectrodes Manufactured from Dispersion Stable Enough for Neural Interfaces

Carbon nanotubes (CNTs) have been proposed as a promising material to enhance the interface between electrodes and neuronal tissue. It has been demonstrated that nanostructured carbon surfaces have the potential to dramatically improve the recording...

Authors: Nick C, Thielemann C

SST Peer Reviewed

Human Lymphatic Endothelial Cells Express Multiple Functional TLRs

The lymphatic endothelium is the preferred route for the drainage of interstitial fluid from tissues and also serves as a conduit for peripheral dendritic cells (DCs) to reach draining lymph nodes. Lymphatic endothelial cells (LECs) are known to...

Authors: Pegu A, Qin S, Fallert Junecko BA, Nisato RE, Pepper MS, Reinhart TA

Sonic Hedgehog-activated engineered blood vessels enhance bone tissue formation

Large bone defects naturally regenerate via a highly vascularized tissue which progressively remodels into cartilage and bone. Current approaches in bone tissue engineering are restricted by delayed vascularization and fail to recapitulate this...

Authors: Rivron NC, Raiss CC, Liu J, Nandakumar A, Sticht C, Gretz N, Truckenmüller R, Rouwkema J, van...

Novel molecular targeting of Necl 5 to prevent intimal hyperplasia and restenosis

Intimal hyperplasia (IH) is implicated in the pathogenesis of restenosis and is the main reason for treatment failure after revascularization procedures. One example of a strategy to reduce restenosis is the use of anti-inflammatory drugs such as...

Authors: Naeem M, Abid R, Murphy T, Park WK, Mills DR

SST Peer Reviewed

Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines

Endosomal TLRs play an important role in innate immune response as well as in autoimmune processes. In the therapy of systemic lupus erythematosus, antimalarial drugs chloroquine, hydroxychloroquine, and quinacrine have been used for a long time....

Authors: Kuznik A, Bencina M, Svajger U, Jeras M, Rozman B, Jerala R.

Use of human embryonic stem cell derived-mesenchymal cells for cardiac repair

Human mesenchymal stem cells (hMSC) have proven beneficial in the repair and preservation of infarcted myocardium. Unfortunately, MSCs represent a small portion of the bone marrow and require ex vivo expansion. To further advance the clinical...

Authors: Simpson DL, Boyd NL, Kaushal S, Stice SL, Dudley SC Jr.

Effect of estrogen on angiogenesis in co-cultures of human endometrial cells and microvascular endothelial cells

BACKGROUND: We recently showed that vascular endothelial growth factor (VEGF) expression by endometrial glandular epithelial and stromal cells, and endometrial microvascular endothelial cell permeability, an early step in angiogenesis, were...

Authors: Albrecht ED1, Babischkin JS, Lidor Y, Anderson LD, Udoff LC, Pepe GJ.

Combining dynamic stretch and tunable stiffness to probe cell mechanobiology in vitro.

Cells have the ability to actively sense their mechanical environment and respond to both substrate stiffness and stretch by altering their adhesion, proliferation, locomotion, morphology, and synthetic profile. In order to elucidate the interrelated...

Authors: Throm Quinlan AM, Sierad LN, Capulli AK, Firstenberg LE, Billiar KL.

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Topic

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Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

Low FasL levels promote proliferation of human bone marrow-derived mesenchymal stem cells, higher levels inhibit their differentiation into adipocytes.

Are Carbon Nanotube Microelectrodes Manufactured from Dispersion Stable Enough for Neural Interfaces

Human Lymphatic Endothelial Cells Express Multiple Functional TLRs

Sonic Hedgehog-activated engineered blood vessels enhance bone tissue formation

Novel molecular targeting of Necl 5 to prevent intimal hyperplasia and restenosis

Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines

Use of human embryonic stem cell derived-mesenchymal cells for cardiac repair

Effect of estrogen on angiogenesis in co-cultures of human endometrial cells and microvascular endothelial cells

Combining dynamic stretch and tunable stiffness to probe cell mechanobiology in vitro.