Search Results

Vascular endothelial growth factor A (VEGF-A) induces endothelial and cancer cell migration through direct binding to integrin 91: identification of a specific 91 binding site.

Integrin a9ß1 mediates accelerated cell adhesion and migration through interactions with a number of diverse extracellular ligands. We have shown previously that it directly binds the vascular endothelial growth factors (VEGF) A, C, and D and...

Authors: Oommen S, Gupta SK, Vlahakis NE.

Human cytomegalovirus interleukin-10 downregulates metalloproteinase activity and impairs endothelial cell migration and placental cytotrophoblast invasiveness in vitro

At the uterine-placental interface, fetal cytotrophoblasts invade the decidua, breach maternal blood vessels, and form heterotypic contacts with uterine microvascular endothelial cells. In early gestation, differentiating- invading cytotrophoblasts...

Authors: Yamamoto-Tabata T, McDonagh S, Chang HT, Fisher S, Pereira L.

The Secretome of Human Bronchial Epithelial Cells Exposed to Fine Atmospheric Particles Induces Fibroblast Proliferation

Chronic exposure to particulate pollution is suspected to exacerbate inflammatory respiratory diseases such as asthma characterized by an airway remodelling involving fibrosis. Our study aims to investigate whether the secretome from human bronchial...

Authors: Boublil L, Martinon L, Baeza-Squiban A

SST Peer Reviewed

Proteomic and metabolomic characterization of CHO DP-12 cell lines with different high passage histories.

Authors: Beckmann T1, Thüte T, Heinrich C, Büntemeyer H, Noll T.

Effects of 9cis,11trans and 10trans,12cis CLA on osteoclast formation and activity from human CD14+ monocytes

BACKGROUND: Mixed CLA isomers variably affect bone resorption in animals and decrease osteoclast formation and activity in murine osteoclasts. These variable effects may be due to the different isomers present in commercial preparations of CLA,...

Authors: Platt I, El-Sohemy A

SST Peer Reviewed

Effects of bone morphogenic proteins and transforming growth factor-beta on In-vitro production of endothelin-1 by human pulmonary microvascular endothelial cells

BACKGROUND: Altered endothelial cell (EC)-derived mediator levels, including increased endothelin-1 (ET-1), are hallmarks of human pulmonary arterial hypertension (PAH). Gene mutations for receptors for bone morphogenic proteins (BMP), or...

Authors: Star GP, Giovinazzo M, Langleben D.

Netrin-4 induces lymphangiogenesis in vivo

Netrin-4, a laminin-related secreted protein is an axon guidance cue recently shown essential outside of the nervous system, regulating mammary and lung morphogenesis as well as blood vascular development. Here, we show that Netrin-4, at physiologic...

Authors: Larrieu-Lahargue F, Welm AL, Thomas KR, Li DY.

The antibody-based delivery of interleukin-12 to the tumor neovasculature eradicates murine models of cancer in combination with paclitaxel.

PURPOSE: Interleukin-12 (IL12) is a potent proinflammatory cytokine with antitumor activity. Its heterodimeric nature makes it compatible with a large variety of different immunocytokine formats. Here we report the design, production, and...

Authors: Pasche N1, Wulhfard S, Pretto F, Carugati E, Neri D.

SST Peer Reviewed

Genome engineering using the CRISPR-Cas9 system

Targeted nucleases are powerful tools for mediating genome alteration with high precision. The RNA-guided Cas9 nuclease from the microbial clustered regularly interspaced short palindromic repeats (CRISPR) adaptive immune system can be used to...

Authors: Ran FA, Hsu PD, Wright J, Agarwala V, Scott DA, Zhang F

SST Peer Reviewed

Nanomaterials enhance osteogenic differentiation of human mesenchymal stem cells similar to a short peptide of BMP-7

BACKGROUND: Nanomaterials have unique advantages in controlling stem cell function due to their biomimetic characteristics and special biological and mechanical properties. Controlling adhesion and differentiation of stem cells is critical for...

Authors: Lock J, Liu H.

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Vascular endothelial growth factor A (VEGF-A) induces endothelial and cancer cell migration through direct binding to integrin 91: identification of a specific 91 binding site.

Human cytomegalovirus interleukin-10 downregulates metalloproteinase activity and impairs endothelial cell migration and placental cytotrophoblast invasiveness in vitro

The Secretome of Human Bronchial Epithelial Cells Exposed to Fine Atmospheric Particles Induces Fibroblast Proliferation

Proteomic and metabolomic characterization of CHO DP-12 cell lines with different high passage histories.

Effects of 9cis,11trans and 10trans,12cis CLA on osteoclast formation and activity from human CD14+ monocytes

Effects of bone morphogenic proteins and transforming growth factor-beta on In-vitro production of endothelin-1 by human pulmonary microvascular endothelial cells

Netrin-4 induces lymphangiogenesis in vivo

The antibody-based delivery of interleukin-12 to the tumor neovasculature eradicates murine models of cancer in combination with paclitaxel.

Genome engineering using the CRISPR-Cas9 system

Nanomaterials enhance osteogenic differentiation of human mesenchymal stem cells similar to a short peptide of BMP-7