Search Results

TNF-alpha's effects on proliferation and apoptosis in human mesenchymal stem cells depend on RUNX2 expression

RUNX2 is a bone-specific transcription factor that plays a critical role in prenatal bone formation and postnatal bone development. It regulates the expression of genes that are important in committing cells into the osteoblast lineage. There is...

Authors: Ghali O, Chauveau C, Hardouin P, Broux O, Devedjian JC.

MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation

Differentiation of mesenchymal stem cells into a particular lineage is tightly regulated, and malfunction of this regulation could lead to pathological consequences. Patients with osteoporosis have increased adipocyte accumulation, but the mechanisms...

Authors: Huang J, Zhao L, Xing L, Chen D.

Decreased circulating soluble Tie2 levels in preeclampsia may result from inhibition of vascular endothelial growth factor (VEGF) signaling

OBJECTIVES: Recent studies have found dysregulation in circulating levels of a number of angiogenic factors and their soluble receptors in preeclampsia. In this study, we examined the mechanism of production of soluble Tie2 (sTie2) and its...

Authors: Sung JF, Fan X, Dhal S, Dwyer BK, Jafari A, El-Sayed YY, Druzin ML, Nayak NR.

A chemically modified antibody mediates complete eradication of tumours by selective disruption of tumour blood vessels.

BACKGROUND: The possibility of eradicating cancer by selective destruction of tumour blood vessels may represent an attractive therapeutic avenue, but most pharmaceutical agents investigated so far did not achieve complete cures and are not...

Authors: Palumbo A1, Hauler F, Dziunycz P, Schwager K, Soltermann A, Pretto F, Alonso C, Hofbauer GF, Boyle...

Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and -3 kinase inhibitors cediranib and vandetanib

Blood vessels are required for a tumor to grow and functional lymphatic vessels are required for it to disseminate to lymph nodes. In an attempt to eradicate both the primary tumor and its lymphatic metastasis, we targeted both blood and lymphatic...

Authors: Padera TP, Kuo AH, Hoshida T, Liao S, Lobo J, Kozak KR, Fukumura D, Jain RK.

Degradation of Proteins for Neural Cell Adhesion Patterning by Carbon Negative-Ion Implantation

Degradations of the adhesive proteins of gelatin (GEL), laminin (LN) and poly-D-lysine (PDL) on polystyrene (PS) by carbon negative-ion implantation for nerve-cell adhesion patterning were investigated. Solutions of adhesive proteins were in the...

Authors: Tsuji H, Sommani P, Sato S, Gotoh Y, Ishikawa J, Takaoka G

SST Peer Reviewed

The density of CD10 corresponds to commitment and progression in the human B lymphoid lineage

BACKGROUND: Requirements for human B lymphopoiesis are still poorly understood, and that has hampered investigation of differentiation events. For example, there are few cell surface antigens that can be used as milestones of lineage progression....

Authors: Ichii M, Oritani K, Yokota T, Zhang Q, Garrett KP, Kanakura Y, Kincade PW.

Drug release from porous silicon for stable neural interface

70 µm-thick porous Si (PSi) layer with the pore size of 11.1 ± 7.6 nm was formed on an 8-in. Si wafer via an anodization process for the microfabrication of a microelectrode to record neural signals. To reduce host tissue responses to the...

Authors: Sun T, Tsang WM, Park WT

SST Peer Reviewed

Influence of the oxygen microenvironment on the proangiogenic potential of human endothelial colony forming cells

Therapeutic angiogenesis is a promising strategy to promote the formation of new or collateral vessels for tissue regeneration and repair. Since changes in tissue oxygen concentrations are known to stimulate numerous cell functions, these studies...

Authors: Decaris ML, Lee CI, Yoder MC, Tarantal AF, Leach JK.

Transcripts of unknown function in multiple-signaling pathways involved in human stem cell differentiation

Mammalian transcriptome analysis has uncovered tens of thousands of novel transcripts of unknown function (TUFs). Classical and recent examples suggest that the majority of TUFs may underlie vital intracellular functions as non-coding RNAs because of...

Authors: Kikuchi K, Fukuda M, Ito T, Inoue M, Yokoi T, Chiku S, Mitsuyama T, Asai K, Hirose T, Aizawa Y.

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