Search Results

Role of microRNA 1207-5P and its host gene, the long non-coding RNA Pvt1, as mediators of extracellular matrix accumulation in the kidney: implications for diabetic nephropathy.

Diabetic nephropathy is the most common cause of chronic kidney failure and end-stage renal disease in the Western World. One of the major characteristics of this disease is the excessive accumulation of extracellular matrix (ECM) in the kidney...

Authors: Alvarez ML1, Khosroheidari M, Eddy E, Kiefer J.

Inhibition of IGF-1R prevents ionizing radiation-induced primary endothelial cell senescence.

Accelerated senescence is a primary response to cellular stresses including DNA damaging agents (e.g., ionizing radiation) and is widely believed to be caused by continuous proliferative signaling in the presence of cell cycle arrest. Studies of...

Authors: Panganiban RA, Day RM.

Human embryonic epidermis contains a diverse Langerhans cell precursor pool.

Despite intense efforts, the exact phenotype of the epidermal Langerhans cell (LC) precursors during human ontogeny has not been determined yet. These elusive precursors are believed to migrate into the embryonic skin and to express primitive surface...

Authors: Schuster C1, Mildner M, Mairhofer M, Bauer W, Fiala C, Prior M, Eppel W, Kolbus A, Tschachler E,...

Stiffness-Activated GEF-H1 Expression Exacerbates LPS-Induced Lung Inflammation.

Acute lung injury (ALI) is accompanied by decreased lung compliance. However, a role of tissue mechanics in modulation of inflammation remains unclear. We hypothesized that bacterial lipopolysacharide (LPS) stimulates extracellular matrix (ECM)...

Authors: Mambetsariev I, Tian Y, Wu T, Lavoie T, Solway J, Birukov KG, Birukova AA.

Erythropoietin is a JAK2 and ERK1/2 effector that can promote renal tumor cell proliferation under hypoxic conditions.

BACKGROUND: Erythropoietin (EPO) provides an alternative to transfusion for increasing red blood cell mass and treating anemia in cancer patients. However, recent studies have reported increased adverse events and/or reduced survival in patients...

Authors: Miyake M1, Goodison S, Lawton A, Zhang G, Gomes-Giacoia E, Rosser CJ

Functional prostacyclin synthase promoter polymorphisms. Impact in pulmonary arterial hypertension.

RATIONALE: Pulmonary arterial hypertension (PAH) is a progressive disease characterized by elevated pulmonary artery pressure, vascular remodeling, and ultimately right ventricular heart failure. PAH can have a genetic component (heritable PAH),...

Authors: Stearman RS, Cornelius AR, Lu X, Conklin DS, Del Rosario MJ, Lowe AM, Elos MT, Fettig LM, Wong RE,...

Interferon-gamma impairs proliferation of hematopoietic stem cells in mice.

Balancing the processes of hematopoietic stem cell (HSC) differentiation and self-renewal is critical for maintaining a lifelong supply of blood cells. The bone marrow (BM) produces a stable output of newly generated cells, but immunologic stress...

Authors: de Bruin AM, Demirel Ö, Hooibrink B, Brandts CH, Nolte MA.

SST Peer Reviewed

The effect of chitin size, shape, source and purification method on immune recognition.

The animal immune response to chitin is not well understood and needs to be investigated further. However, this is a challenging topic to study because of the technical difficulties in purifying chitin, and because this material usually comes...

Authors: Alvarez FJ.

Myeloblastic cell lines mimic some but not all aspects of human cytomegalovirus experimental latency defined in primary CD34+ cell populations.

Human cytomegalovirus (HCMV) is a significant human pathogen that achieves lifelong persistence by establishing latent infections in undifferentiated cells of the myeloid lineage, such as CD34(+) hematopoietic progenitor cells. When latency is...

Authors: Albright ER1, Kalejta RF

SST Peer Reviewed

Fungal chitin dampens inflammation through IL-10 induction mediated by NOD2 and TLR9 activation.

Chitin is an essential structural polysaccharide of fungal pathogens and parasites, but its role in human immune responses remains largely unknown. It is the second most abundant polysaccharide in nature after cellulose and its derivatives today are...

Authors: Wagener J1, Malireddi RK2, Lenardon MD1, Köberle M3, Vautier S1, MacCallum DM1, Biedermann T3,...

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