Search Results

Nucleosome occupancy reveals regulatory elements of the CFTR promoter.

Access to regulatory elements of the genome can be inhibited by nucleosome core particles arranged along the DNA strand. Hence, sites that are accessible by transcription factors may be located by using nuclease digestion to identify the relative...

Authors: Ott CJ, Bischof JM, Unti KM, Gillen AE, Leir SH, Harris A.

Long-lived microRNA-Argonaute complexes in quiescent cells can be activated to regulate mitogenic responses.

Cellular proliferation depends on the integration of mitogenic stimuli with environmental conditions. Increasing evidence suggests that microRNAs play a regulatory role in this integration. Here we show that during periods of cellular quiescence,...

Authors: Olejniczak SH, La Rocca G, Gruber JJ, Thompson CB

SST Peer Reviewed

Efficient gene delivery to primary alveolar epithelial cells by nucleofection.

Primary alveolar epithelial cells play a pivotal role in lung research, particularly when focusing on gas exchange, barrier function and transepithelial transport processes. However, efficient transfection of primary alveolar epithelial cells...

Authors: Grzesik BA, Vohwinkel CU, Morty RE, Mayer K, Herold S, Seeger W, Vadász I.

Multielectrode array analysis of cerebrospinal fluid in Alzheimer\'s disease versus mild cognitive impairment: a potential diagnostic and treatment biomarker

Pathological cerebrospinal fluid (CSF) alterations like changes in amyloid-ß1-42 and tau protein concentration are typical in Alzheimer's disease (AD). However, it remains unclear, if the composition of known or unknown pathological factors in native...

Authors: Görtz P, Siebler M, Ihl R, Henning U, Luckhaus C, Supprian T, Lange-Asschenfeldt C

Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells.

BACKGROUND: The full length Rad51 promoter is highly active in cancer cells but not in normal cells. We therefore set out to assess whether we could confer this tumor-selectivity to an adenovirus vector. METHODOLOGY/PRINCIPAL FINDINGS: Expression of...

Authors: Fong V, Osterbur M, Capella C, Kim YE, Hine C, Gorbunova V, Seluanov A, Dewhurst S

Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptors.

Chronic immune activation in HIV-infected individuals leads to accumulation of exhausted tissue-like memory B cells. Exhausted lymphocytes display increased expression of multiple inhibitory receptors, which may contribute to the inefficiency of...

Authors: Kardava L, Moir S, Wang W, Ho J, Buckner CM, Posada JG, O\'Shea MA, Roby G, Chen J, Sohn HW, Chun...

SST Peer Reviewed

Aldose reductase inhibition prevents metaplasia of airway epithelial cells.

BACKGROUND: Goblet cell metaplasia that causes mucus hypersecretion and obstruction in the airway lumen could be life threatening in asthma and chronic obstructive pulmonary disease patients. Inflammatory cytokines such as IL-13 mediate the...

Authors: Yadav UC, Aguilera-Aguirre L, Ramana KV, Boldogh I, Srivastava SK

Polymer peel-off mask for high-resolution surface derivatization, neuron placement and guidance

We present a dry lift-off method using a chemically resistant spin-on plastic, polyimide, to pattern surfaces with high accuracy and resolution. Using well-known lithographic and reactive ion etching techniques, the spin-on polymer is patterned over...

Authors: Martinez D, Py C, Denhoff M, Monette R, Comas T, Krantis A, Mealing G

Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptors.

Chronic immune activation in HIV-infected individuals leads to accumulation of exhausted tissue-like memory B cells. Exhausted lymphocytes display increased expression of multiple inhibitory receptors, which may contribute to the inefficiency of...

Authors: Kardava L, Moir S, Wang W, Ho J, Buckner CM, Posada JG, O'Shea MA, Roby G, Chen J, Sohn HW, Chun TW,...

SST Peer Reviewed

Down-regulation of canonical and up-regulation of non-canonical Wnt signalling in the carcinogenic process of squamous cell lung carcinoma

The majority of lung cancers (LC) belong to the non-small cell lung carcinoma (NSCLC) type. The two main NSCLC sub-types, namely adenocarcinoma (AC) and squamous cell carcinoma (SCC), respond differently to therapy. Whereas the link between cigarette...

Authors: Bartis D, Csongei V, Weich A, Kiss E, Barko S, Kovacs T, Avdicevic M, D'Souza VK, Rapp J, Kvell K,...

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Category

Research Area

Platform

Topic

Species

Characteristic

Format

Origin

Nucleosome occupancy reveals regulatory elements of the CFTR promoter.

Long-lived microRNA-Argonaute complexes in quiescent cells can be activated to regulate mitogenic responses.

Efficient gene delivery to primary alveolar epithelial cells by nucleofection.

Multielectrode array analysis of cerebrospinal fluid in Alzheimer\'s disease versus mild cognitive impairment: a potential diagnostic and treatment biomarker

Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells.

Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptors.

Aldose reductase inhibition prevents metaplasia of airway epithelial cells.

Polymer peel-off mask for high-resolution surface derivatization, neuron placement and guidance

Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptors.

Down-regulation of canonical and up-regulation of non-canonical Wnt signalling in the carcinogenic process of squamous cell lung carcinoma