Search Results

Activated Ras induces cytoplasmic vacuolation and non-apoptotic death in glioblastoma cells via novel effector pathways

Expression of activated H-Ras induces a unique form of non-apoptotic cell death in human glioblastoma cells and other specific tumor cell lines. The major cytopathological features of this form of death are the accumulation of large phase-lucent,...

Authors: Kaul A, Overmeyer JH, Maltese WA

Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons

The flotillins/reggie proteins are associated with noncaveolar membrane microdomains and have been implicated in the regulation of a clathrin- and caveolin-independent endocytosis pathway. Endocytosis is required for the amyloidogenic processing of...

Authors: Schneider A, Rajendran L, Honsho M, Gralle M, Donnert G, Wouters F, Hell SW, Simons M

In vitro expression of erythropoietin by transfected human mesenchymal stromal cells

BACKGROUND: Mesenchymal stromal cells (MSC) are pluripotent progenitor cells that can be found in human bone marrow (BM). These cells have low immunogenicity and could suppress alloreactive T-cell responses. In the current study, MSC were tested for...

Authors: Mok PL, Cheong SK, Leong CF, Othman A

SST Peer Reviewed

Synaptic function for the Nogo-66 receptor NgR1: regulation of dendritic spine morphology and activity-dependent synaptic strength

In the mature nervous system, changes in synaptic strength correlate with changes in neuronal structure. Members of the Nogo-66 receptor family have been implicated in regulating neuronal morphology. Nogo-66 receptor 1 (NgR1) supports binding of the...

Authors: Lee H, Raiker SJ, Venkatesh K, Geary R, Robak LA, Zhang Y, Yeh HH, Shrager P, Giger RJ

Knockdown of ACAT-1 reduces amyloidogenic processing of APP

Previous studies have shown that acyl-coenzyme A:cholesterol acyl transferase (ACAT), an enzyme that controls cellular equilibrium between free cholesterol and cholesteryl esters, modulates proteolytic processing of APP in cell-based and animal...

Authors: Huttunen HJ, Greco C, Kovacs DM

Molecular Basis of Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) Cytotoxicity in EBV Latency III B-cells: LMP1 induces type II Ligand independent Autoactivation of CD95/Fas with Caspase-8 mediated Apoptosis

Epstein-Barr-Virus (EBV) oncoprotein LMP1 (Latent Membrane Protein 1) is thought to be the major transforming protein in various cell types, by rerouting the TNF receptor family signalling pathway. Despite this implication in EBV-associated...

Authors: Le Clorennec C, Ouk TS, Youlyouz-Marfak I, Panteix S, Martin CC, Rastelli J, Adriaenssens E,...

The MHV68 M2 protein drives IL-10 dependent B cell proliferation and differentiation

Murine gammaherpesvirus 68 (MHV68) establishes long-term latency in memory B cells similar to the human gammaherpesvirus Epstein Barr Virus (EBV). EBV encodes an interleukin-10 (IL-10) homolog and modulates cellular IL-10 expression; however, the...

Authors: Siegel AM, Herskowitz JH, Speck SH

Targeted deletion of SAP1 abolishes the expression of infectivity factors necessary for successful malaria parasite liver infection

Malaria parasite sporozoites prepare for transmission to a mammalian host by upregulation of UIS (Upregulated in Infectious Sporozoites) genes. A number of UIS gene products are essential for the establishment of the intrahepatocytic niche. However,...

Authors: Aly AS, Mikolajczak SA, Rivera HS, Camargo N, Jacobs-Lorena V, Labaied M, Coppens I, Kappe SH

Three-dimensional FRET reconstruction microscopy for analysis of dynamic molecular interactions in live cells

Analysis of cellular pathways requires concentration measurements of dynamically interacting molecules within the 3D space of single living cells. Förster Resonance Energy Transfer (FRET) microscopy from widefield, confocal, and potentially from...

Authors: Hoppe AD, Shorte SL, Swanson JA, Heintzmann R

Rapid leukocyte migration by integrin-independent flowing and squeezing

All metazoan cells carry transmembrane receptors of the integrin family, which couple the contractile force of the actomyosin cytoskeleton to the extracellular environment. In agreement with this principle, rapidly migrating leukocytes use...

Authors: Laemmermann T, Bader BL, Monkley SJ, Worbs T, Wedlich-Söldner R, Hirsch K, Keller M, Förster R,...

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