Search Results

Spatial distribution of protein damage by singlet oxygen in keratinocytes

Singlet oxygen may be generated in cells by either endogenous or exogenous photosensitizers as a result of exposure to UV or visible irradiation. We have used immuno-spin trapping (Free Radic. Biol. Med. 36: 1214, 2004) to identify the subcellular...

Authors: He YY, Council SE, Feng L, Bonini MG, Chignell CF

Inflammatory signaling and aryl hydrocarbon receptor mediate synergistic induction of interleukin 6 in MCF-7 cells

The pleiotropic cytokine interleukin 6 (IL-6) is involved in immune cell homeostasis. Additionally, IL-6 expression and signaling in tumor cells have been shown to elicit both protumor and antitumor properties. There is a plethora of mechanistic...

Authors: Hollingshead BD, Beischlag TV, Dinatale BC, Ramadoss P, Perdew GH

NAIP and Ipaf control Legionella pneumophila replication in human cells

In mice, different alleles of the mNAIP5 (murine neuronal apoptosis inhibitory protein-5)/mBirc1e gene determine whether macrophages restrict or support intracellular replication of Legionella pneumophila, and whether a mouse is resistant or...

Authors: Vinzing M, Eitel J, Lippmann J, Hocke AC, Zahlten J, Slevogt H, N'guessan PD, Günther S, Schmeck B,...

Munc13-4 regulates granule secretion in human neutrophils

The neutrophil plays a central role in the innate host immune defense. Regulated exocytosis of its granules and release of antimicrobial and cytotoxic substances are key events to limit the spread of pathogens. However, the molecular mechanisms that...

Authors: Pivot-Pajot C, Varoqueaux F, de Saint Basile G, Bourgoin SG

Store-dependent and -independent modes regulating CRAC channel activity of human Orai1 and Orai3

We evaluated currents induced by expression of human homologs of Orai together with STIM1 in HEK cells. When coexpressed with STIM1, Orai1 induced a large inwardly rectifying Ca2+ selective current with Ca2+-induced slow inactivation. A point...

Authors: Zhang SL, Kozak JA, Jiang W, Yeromin AV, Chen J, Yu Y, Penna A, Shen W, Chi V, Cahalan MD

UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/Cyclin D1 pathways in keratinocytes

UVA (315-400 nm), which constitutes approximately 95% of the UV irradiation in natural sunlight, represents a major environmental challenge to the skin and is clearly associated with human skin cancer. Here, we show that a low, nonlethal dose of UVA...

Authors: He YY, Council SE, Feng L, Chignell CF

SST Peer Reviewed

Signaling mechanism of HIV-1 gp120 and virion-induced IL-1beta release in primary human macrophages

HIV-1 envelope glycoprotein gp120 induces, independently of infection, the release of proinflammatory cytokines, including IL-1beta from macrophages, that are implicated in the pathogenesis of HIV-associated dementia. However, the signal transduction...

Authors: Cheung R, Ravyn V, Wang L, Ptasznik A, Collman RG

Phosphorylation regulates transcriptional activity of PAX3/FKHR and reveals novel therapeutic possibilities

Inhibition of constitutive active signaling pathways, which are a characteristic phenomenon for many tumors, can be an effective therapeutic strategy. In contrast, oncogenic transcription factors, often activated by mutational events, are in general...

Authors: Amstutz R, Wachtel M, Troxler H, Kleinert P, Ebauer M, Haneke T, Oehler-Jänne C, Fabbro D, Niggli...

Actin-binding protein 1 regulates B cell receptor-mediated antigen processing and presentation in response to B cell receptor activation

The BCR serves as both signal transducer and Ag transporter. Binding of Ags to the BCR induces signaling cascades and Ag processing and presentation, two essential cellular events for B cell activation. BCR-initiated signaling increases BCR-mediated...

Authors: Onabajo OO, Seeley MK, Kale A, Qualmann B, Kessels M, Han J, Tan TH, Song W

VSV oncolysis of T lymphocytes requires cell cycle entry and translation initiation

Vesicular stomatitis virus (VSV) is a candidate oncolytic virus that replicates and induces cell death in cancer cells while sparing normal cells. Although defects in the interferon (IFN) antiviral response facilitate VSV oncolysis, other host...

Authors: Oliere S, Arguello M, Mesplede T, Tumilasci V, Nakhaei P, Stojdl D, Sonenberg N, Bell J, Hiscott J

Data Type

Category

Research Area

Platform

Topic

Species

Characteristic

Format

Origin