Search Results

Spontaneous cancer-stromal cell fusion as a mechanism of prostate cancer androgen-independent progression.

We have previously shown that human prostate cancer cells are capable of acquiring malignant attributes through interaction with stromal cells in the tumor microenvironment, while the interacting stromal cells can also become affected with both...

Authors: Wang R1, Sun X, Wang CY, Hu P, Chu CY, Liu S, Zhau HE, Chung LW.

The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration

The transcription factor hypoxia-inducible factor-1 (HIF-1) represents an important molecular target for anticancer drug discovery. In a T47D cell-based reporter assay, the Caulerpa spp. algal pigment caulerpin (1) inhibited hypoxia-induced as well...

Authors: Liu Y1, Morgan JB, Coothankandaswamy V, Liu R, Jekabsons MB, Mahdi F, Nagle DG, Zhou YD.

Gene mutation in microRNA target sites of CFTR gene: a novel pathogenetic mechanism in cystic fibrosis?

Cystic fibrosis (CF) is the most frequent lethal genetic disorder among Caucasians. It depends on alterations of a chloride channel expressed by most epithelial cells and encoded by CFTR gene. Also using scanning techniques to analyze the whole...

Authors: Amato F1, Seia M, Giordano S, Elce A, Zarrilli F, Castaldo G, Tomaiuolo R

Metabolism and regulation of gene expression by 4-oxoretinol versus all-trans retinoic acid in normal human mammary epithelial cells

We previously demonstrated that 4-oxoretinol (4-oxo-ROL) activated retinoic acid receptors (RARs) in F9 stem cells. We showed that 4-oxo-ROL inhibited the proliferation of normal human mammary epithelial cells (HMECs). To understand the mechanisms by...

Authors: Liu L1, Derguini F, Gudas LJ.

Context-specific roles for paracrine IL-6 in lymphomagenesis.

A basic requirement for the development of complex organ systems is that the cellular response to identical environmental cues can vary significantly between distinct cell types and developmental stages. While it is well established that paracrine...

Authors: Gilbert LA1, Hemann MT.

Negative regulatory responses to metabolically triggered inflammation impair renal epithelial immunity in diabetes mellitus

Diabetes mellitus is characterized by chronic inflammation and increased risk of infections, particularly of tissues exposed to the external environment. However, the causal molecular mechanisms that affect immune cells and their functions in...

Authors: Chen NK1, Chong TW, Loh HL, Lim KH, Gan VH, Wang M, Kon OL

Tuning composition and architecture of biomimetic scaffolds for enhanced matrix synthesis by murine cardiomyocytes.

A major onset of heart failure is myocardial infarction, which causes the myocardium to lose cardiomyocytes and transform into a scar tissue. Since mammalian infarcted cardiac tissue has a limited ability to regenerate, alternative strategies...

Authors: Gishto A, Farrell K, Kothapalli CR

SST Peer Reviewed

Cross talk between engulfment receptors stabilin-2 and integrin avß5 orchestrates engulfment of phosphatidylserine-exposed erythrocytes.

Efficient cell corpse clearance is critical for health in organisms. Apoptotic cells displaying phosphatidylserine (PS) are recognized by engulfment receptors and ingested through two conserved pathways. In one pathway, engulfment receptor...

Authors: Kim S1, Park SY, Kim SY, Bae DJ, Pyo JH, Hong M, Kim IS.

Upregulation of Runx2 and Osterix during in vitro chondrogenesis of human adipose-derived stromal cells.

The aim of this study was to create a gene expression profile to better define the phenotype of human adipose-derived stromal cells (HADSCs) during in vitro chondrogenesis, osteogenesis and adipogenesis. A novel aspect of this work was the analysis...

Authors: Rich JT, Rosová I, Nolta JA, Myckatyn TM, Sandell LJ, McAlinden A.

SST Peer Reviewed

1-O-hexadecyloxypropyl cidofovir (CMX001) effectively inhibits polyomavirus BK replication in primary human renal tubular epithelial cells

Antiviral drugs for treating polyomavirus BK (BKV) replication in polyomavirus-associated nephropathy or hemorrhagic cystitis are of considerable clinical interest. Unlike cidofovir, the lipid conjugate 1-O-hexadecyloxypropyl cidofovir (CMX001) is...

Authors: Rinaldo CH1, Gosert R, Bernhoff E, Finstad S, Hirsch HH

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