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Experimental non-ATP-competitive therapies for chronic myelogenous leukemia

Chronic myelogenous leukemia (CML) is a hematopoietic stem cell malignancy driven by the BCR-ABL fusion tyrosine kinase. The central role played by BCR-ABL1 in the pathogenesis of CML facilitated the development of the tyrosine kinase inhibitor (TKI)...

Authors: Quintas-Cardama A

Comparison of zinc finger nucleases for use in gene targeting in mammalian cells

Homologous recombination is a technique used for performing precise genomic manipulations, and this makes it potentially ideal for gene therapy. The rate of spontaneous homologous recombination in human cells has been too low to be used...

Authors: Pruett-Miller SM, Connelly JP, Maeder ML, Joung JK, Porteus MH

Protein kinase A-induced phosphorylation of the p65 subunit of nuclear factor-kappaB promotes Schwann cell differentiation into a myelinating phenotype

Axon-Schwann cell interactions are critical for myelin formation during peripheral nerve development and regeneration. Axonal contact promotes Schwann cell precursors to differentiate into a myelinating phenotype, and cAMP-elevating agents can mimic...

Authors: Yoon C, Korade Z, Carter BD

MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells

Loss of microRNA (miRNA) pathway components negatively affects differentiation of embryonic stem (ES) cells, but the underlying molecular mechanisms remain poorly defined. Here we characterize changes in mouse ES cells lacking Dicer (Dicer1)....

Authors: Sinkkonen L, Hugenschmidt T, Berninger P, Gaidatzis D, Mohn F, Artus-Revel CG, Zavolan M, Svoboda P,...

SST Peer Reviewed

HIV-1 Vpr binds to the N-lobe of Wee1 kinase domain and enhances kinase activity for Cdc2

HIV-1 Vpr is a virion associated accessory protein that has multiple activities within an infected cell. One of the most dramatic effects of Vpr is the induction of cell cycle arrest at the G2/M boundary, followed by apoptosis. This effect has...

Authors: Kamata M, Watanabe N, Nagaoka Y, Chen IS

Protein 600 is a microtubule/endoplasmic reticulum-associated protein in CNS neurons

There is an increasing body of literature pointing to cytoskeletal proteins as spatial organizers and interactors of organelles. In this study, we identified protein 600 (p600) as a novel microtubule-associated protein (MAP) developmentally regulated...

Authors: Shim SY, Wang J, Asada N, Neumayer G, Tran HC, Ishiguro K, Sanada K, Nakatani Y, Nguyen MD

Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection

Transcription factor FOXO3a controls The persistence of central memory CD4(+) T cells (T(CM) cells) is a major correlate of immunological protection in HIV/AIDS, as the rate of T(CM) cell decline predicts HIV disease progression. In this study, we...

Authors: van Grevenynghe J, Procopio FA, He Z, Chomont N, Riou C, Zhang Y, Gimmig S, Boucher G, Wilkinson P,...

Overexpression of mitochondrial methionine sulfoxide reductase B2 protects Leukemia cells from oxidative stress-induced cell death and protein damage

According to the mitochondrial theory of aging, mitochondrial dysfunction increases intracellular reactive oxidative species production leading to the oxidation of macromolecules and ultimately to cell death. In this study we investigated the role of...

Authors: Cabreiro F, Picot CR, Perichon M, Castel J, Friguet B, Petropoulos I

The kinesin KIF1B-beta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor

VHL, NF-1, c-Ret, and Succinate Dehydrogenase Subunits B and D act on a developmental apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for neuronal progenitor cells and requires the EglN3 prolyl hydroxylase as a...

Authors: Schlisio S, Kenchappa RS, Vredeveld LC, George RE, Stewart R, Greulich H, Shahriari K, Nguyen NV,...

Kindlin-3 is essential for integrin activation and platelet aggregation

Integrin-mediated platelet adhesion and aggregation are essential for sealing injured blood vessels and preventing blood loss, and excessive platelet aggregation can initiate arterial thrombosis, causing heart attacks and stroke. To ensure that...

Authors: Moser M, Nieswandt B, Ussar S, Pozgajova M, Faessler R

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