Search Results

XBP-1, a novel HTLV-1 Tax binding protein, activates HTLV-1 basal and Tax-activated transcription

X-box binding protein 1 (XBP-1), a basic leucine zipper transcription factor, plays a key role in cellular unfolded protein response (UPR). There are two XBP-1 isoforms in cells, the spliced XBP-1S and the unspliced XBP-1U. XBP-1U has been shown to...

Authors: Ku SC, Lee J, Lau J, Gurumurthy M, Ng R, Lwa SH, Lee J, Klase Z, Kashanchi F, Chao SH

HoxA9 induces insulin-like growth factor-1 receptor expression in B-lineage acute lymphoblastic leukemia

The homeobox (Hox) gene family encodes a group of transcription factors preferentially expressed during embryonic development and hematopoiesis. Deregulation of Hox gene expression is frequently associated with acute leukemia. HoxA9 is the most...

Authors: Whelan JT, Ludwig DL, Bertrand FE

Involvement of protective autophagy in TRAIL-resistance of apoptosis defective tumor cells

Targeting TRAIL-Rs with either recombinant TRAIL or agonistic DR4 or DR5-specific antibodies has been considered a promising treatment for cancer, particularly due to the preferential apoptotic susceptibility of tumor cells over normal cells to...

Authors: Han J, Hou W, Goldstein LA, Lu C, Stolz DB, Yin XM, Rabinowich H

RNA-loaded CD40-activated B cells stimulate antigen-specific T-cell responses in dogs with spontaneous lymphoma

Cell-based vaccination strategies to induce functional tumor-specific T cells in cancer patients have focused on using autologous dendritic cells. An alternative approach is to use RNA-loaded CD40 activated B cells (CD40-B) that are highly efficient...

Authors: Mason NJ, Coughlin CM, Overley B, Cohen JN, Mitchell EL, Colligon TA, Clifford CA, Zurbriggen A,...

Impaired Bcl3 up-regulation leads to enhanced LPS-induced IL-23p19 gene expression in IL-10-/- mice

Genetic and biochemical analyses show that IL-23p19 plays a central role in mediating bacteria-induced colitis in Interleukin-10 deficient (IL-10-/-) mice. The molecular mechanisms responsible for the dysregulated innate host response leading to...

Authors: Muehlbauer M, Chilton PM, Mitchell TC, Jobin C

NF-kappaB-mediated activation of the chemokine CCL22 by the product of the human cytomegalovirus gene UL144 escapes regulation by viral IE86

The product of the human cytomegalovirus (HCMV) gene UL144, expressed at early times postinfection, is located in the UL/b' region of the viral genome and is related to members of the tumor necrosis factor receptor superfamily, but it does not bind...

Authors: Poole E, Atkins E, Nakayama T, Yoshie O, Groves I, Alcami A, Sinclair J

Cholesterol Loss Enhances TrkB Signaling in Hippocampal Neurons Aging in Vitro

Binding of the neurotrophin BDNF to the TrkB receptor is a major survival mechanism during embryonic development. In the aged brain however, BDNF levels are low, suggesting that if TrkB is to play a role in survival at this stage additional...

Authors: Martin MG, Perga S, TrovÜ² L, Rasola A, Holm P, Rantamäki T, Harkany T, Castrén E, Chiara F, Dotti...

Regulation of Self-renewal and Pluripotency by Sox2 in Human Embryonic Stem Cells

Human embryonic stem (hES) cells, derived from blastocysts, are capable of unlimited self-renewal and differentiation into all cell lineages of the body. Because of their pluripotent nature, hES cells are valuable tools for understanding human...

Authors: Fong H, Hohenstein KA, Donovan PJ

SST Peer Reviewed

Bax siRNA promotes survival of cultured and allografted granule cell precursors through blockade of caspase-3 cleavage

Transplantation of neuronal precursor cells (NPCs) into the central nervous system could represent a powerful therapeutical tool against neurodegenerative diseases. Unfortunately, numerous NPCs die shortly after transplantation, predominantly due to...

Authors: Zhokhov SS, Desfeux A, Aubert N, Falluel-Morel A, Fournier A, Laudenbach V, Vaudry H, Gonzalez BJ

SST Peer Reviewed

Subversion of CtBP1-controlled macropinocytosis by human adenovirus serotype 3

Endocytosis supports cell communication, growth, and pathogen infection. The species B human adenovirus serotype 3 (Ad3) is associated with epidemic conjunctivitis, and fatal respiratory and systemic disease. Here we show that Ad3 uses...

Authors: Amstutz B, Gastaldelli M, Kälin S, Imelli N, Boucke K, Wandeler E, Mercer J, Hemmi S, Greber UF

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