Search Results

Primary cilia are decreased in breast cancer: analysis of a collection of human breast cancer cell lines and tissues

Primary cilia (PC) are solitary, sensory organelles that are critical for several signaling pathways. PC were detected by immunofluorescence of cultured cells and breast tissues. After growth for 7 days in vitro, PC were detected in ~70% of breast...

Authors: Yuan K1, Frolova N, Xie Y, Wang D, Cook L, Kwon YJ, Steg AD, Serra R, Frost AR.

Cbl-b mediates TGFß sensitivity by downregulating inhibitory SMAD7 in primary T cells.

T cell-intrinsic transforming growth factor ß (TGFß) receptor signaling plays an essential role in controlling immune responses. The RING-type E3 ligase Cbl-b has been shown to mediate the sensitivity of T cells to TGFß; however, the mechanism...

Authors: Gruber T1, Hinterleitner R, Hermann-Kleiter N, Meisel M, Kleiter I, Wang CM, Viola A,...

Hypoxia negatively regulates antimetastatic PEDF in melanoma cells by a hypoxia inducible factor-independent, autophagy dependent mechanism

Pigment epithelium-derived factor (PEDF), a member of the serine protease inhibitor (SERPIN) superfamily, displays a potent antiangiogenic and antimetastatic activity in a broad range of tumor types. Melanocytes and low aggressive melanoma cells...

Authors: Fernández-Barral A1, Orgaz JL, Gomez V, del Peso L, Calzada MJ, Jiménez B.

Mesenchymal stem cells modulate albumin-induced renal tubular inflammation and fibrosis

Bone marrow-derived mesenchymal stem cells (BM-MSCs) have recently shown promise as a therapeutic tool in various types of chronic kidney disease (CKD) models. However, the mechanism of action is incompletely understood. As renal prognosis in CKD is...

Authors: Wu HJ1, Yiu WH1, Li RX1, Wong DW1, Leung JC1, Chan LY1, Zhang Y2, Lian Q3, Lin M1, Tse HF2, Lai KN1,...

Human leukocyte antigen E contributes to protect tumor cells from lysis by natural killer cells.

The nonclassic class I human leukocyte antigen E (HLA-E) molecule engages the inhibitory NKG2A receptor on several cytotoxic effectors, including natural killer (NK) cells. Its tissue distribution was claimed to be wider in normal than in neoplastic...

Authors: Lo Monaco E1, Tremante E, Cerboni C, Melucci E, Sibilio L, Zingoni A, Nicotra MR, Natali PG,...

Characterization and clinical evaluation of CD10+ stroma cells in the breast cancer microenvironment.

PURPOSE: There is growing evidence that interaction between stromal and tumor cells is pivotal in breast cancer progression and response to therapy. Based on earlier research suggesting that during breast cancer progression, striking changes occur in...

Authors: Desmedt C1, Majjaj S, Kheddoumi N, Singhal SK, Haibe-Kains B, El Ouriaghli F, Chaboteaux C, Michiels...

Intracellular targets of RGDS peptide in melanoma cells

BACKGROUND: RGD-motif acts as a specific integrins-ligand and regulates a variety of cell-functions via extracellular action affecting cell-adhesion properties. However, increasing evidence identifies additional RGDS-functions at intracellular...

Authors: Aguzzi MS1, Fortugno P, Giampietri C, Ragone G, Capogrossi MC, Facchiano A.

Development of a repeated exposure protocol of human bronchial epithelium in vitro to study the long-term effects of atmospheric particles.

Chronic exposure to atmospheric particles is suspected of exacerbating chronic inflammatory respiratory diseases but the underlying mechanisms remain poorly understood. An experimental strategy using human bronchial epithelial cells (NHBE) known to...

Authors: Boublil L1, Assémat E, Borot MC, Boland S, Martinon L, Sciare J, Baeza-Squiban A.

Identification of early gene expression changes during human Th17 cell differentiation.

Th17 cells play an essential role in the pathogenesis of autoimmune and inflammatory diseases. Most of our current understanding on Th17 cell differentiation relies on studies carried out in mice, whereas the molecular mechanisms controlling human...

Authors: Tuomela S1, Salo V, Tripathi SK, Chen Z, Laurila K, Gupta B, Äijö T, Oikari L, Stockinger B,...

Systematic verification of upstream regulators of a computable cellular proliferation network model on non-diseased lung cells using a dedicated dataset.

We recently constructed a computable cell proliferation network (CPN) model focused on lung tissue to unravel complex biological processes and their exposure-related perturbations from molecular profiling data. The CPN consists of edges and nodes...

Authors: Belcastro V1, Poussin C, Gebel S, Mathis C, Schlage WK, Lichtner RB, Quadt-Humme S, Wagner S, Hoeng...

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