Search Results

Hypoxia-mediated Up-regulation of Metastatic Genes in Human Tongue Oral Squamous Cell Carcinoma: [Part I] Urokinase Plasminogen Activator [uPA]

Background: Most human tumors develops regions of chronically or transient hypoxic cells during growth. The effect of hypoxia on tumor tissue has a strong impact on tumor cell migration and metastatic behavior. uPA a major member plasminogen...

Authors: Khaled M. Mohamed, BDS, MDS, PhD.

Endotoxin emissions from commercial composting activities.

This paper describes an exploratory study of endotoxin emissions and dispersal from a commercial composting facility. Replicated samples of air were taken by filtration at different locations around the facility on 10 occasions. Measurements were...

Authors: Deacon L1, Pankhurst L, Liu J, Drew GH, Hayes ET, Jackson S, Longhurst J, Longhurst P, Pollard S,...

Hair cycle control by leptin as a new anagen inducer.

Our purpose is to clarify the physiological role of leptin in hair cycle as leptin reportedly causes activation of Stat3, which is indispensable for hair cycling. While hair follicles in dorsal skin of 5-week-old C57/BL6 mice had progressed to late...

Authors: Sumikawa Y, Inui S, Nakajima T, Itami S.

A transient disruption of fibroblastic transcriptional regulatory network facilitates trans-differentiation

Authors: Tomaru Y, Hasegawa R, Suzuki T, Sato T, Kubosaki A, Suzuki M, Kawaji H, Forrest AR, Hayashizaki Y;...

Cutting edge: Immunity against a \\\"silent\\\" salivary antigen of the Lyme vector Ixodes scapularis impairs its ability to feed.

Ixodes scapularis ticks transmit the Lyme disease agent in the United States. Although strong antitick immunity mediates tick rejection by certain vertebrates, only a few Ags have been molecularly characterized. We show that guinea pig vaccination...

Authors: Kotsyfakis M1, Anderson JM, Andersen JF, Calvo E, Francischetti IM, Mather TN, Valenzuela JG,...

A small-molecule blocking ribonucleotide reductase holoenzyme formation inhibits cancer cell growth and overcomes drug resistance

Ribonucleotide reductase (RNR) is an attractive target for anticancer agents given its central function in DNA synthesis, growth, metastasis, and drug resistance of cancer cells. The current clinically established RNR inhibitors have the shortcomings...

Authors: Zhou B, Su L, Hu S, Hu W, Yip ML, Wu J, Gaur S, Smith DL, Yuan YC, Synold TW, Horne D, Yen Y

Hsp90 chaperone inhibitor 17-AAG attenuates Aß-induced synaptic toxicity and memory impairment.

The excessive accumulation of soluble amyloid peptides (Aß) plays a crucial role in the pathogenesis of Alzheimer's disease (AD), particularly in synaptic dysfunction. The role of the two major chaperone proteins, Hsp70 and Hsp90, in clearing...

Authors: Chen Y1, Wang B, Liu D, Li JJ, Xue Y, Sakata K, Zhu LQ, Heldt SA, Xu H, Liao FF

SST Peer Reviewed

The immunomodulatory action of sialostatin L on dendritic cells reveals its potential to interfere with autoimmunity.

Sialostatin L (SialoL) is a secreted cysteine protease inhibitor identified in the salivary glands of the Lyme disease vector Ixodes scapularis. In this study, we reveal the mechanisms of SialoL immunomodulatory actions on the vertebrate host....

Authors: Sá-Nunes A1, Bafica A, Antonelli LR, Choi EY, Francischetti IM, Andersen JF, Shi GP, Chavakis T,...

High molecular weight fibroblast growth factor-2 in the human heart is a potential target for prevention of cardiac remodeling

Fibroblast growth factor 2 (FGF-2) is a multifunctional protein synthesized as high (Hi-) and low (Lo-) molecular weight isoforms. Studies using rodent models showed that Hi- and Lo-FGF-2 exert distinct biological activities: after myocardial...

Authors: Santiago JJ, McNaughton LJ, Koleini N1, Ma X, Bestvater B, Nickel BE, Fandrich RR, Wigle JT, Freed...

Epidermal or dermal specific knockout of PHD-2 enhances wound healing and minimizes ischemic injury

Hypoxia-inducible factor (HIF)-1a, part of the heterodimeric transcription factor that mediates the cellular response to hypoxia, is critical for the expression of multiple angiogenic growth factors, cell motility, and the recruitment of endothelial...

Authors: Zimmermann AS, Morrison SD, Hu MS, Li S, Nauta A, Sorkin M, Meyer NP, Walmsley GG, Maan ZN, Chan DA,...

Data Type

Category

Research Area

Platform

Topic

Species

Characteristic

Format

Origin