Search Results

Bifunctional Role of Rev-erb alpha in Adipocyte Differentiation

The nuclear receptor Rev-erbalpha is a potent transcriptional repressor that regulates circadian rhythm and metabolism. Here we demonstrate a dissociation between Rev-erbalpha mRNA and protein levels that profoundly influences adipocyte...

Authors: Wang J, Lazar MA

Phosphorylation of LXR alpha Selectively Regulates Target Gene Expression in Macrophages

Dysregulation of LXRalpha activity has been linked to cardiovascular and metabolic diseases. Here, we show that LXRalpha target gene selectivity is achieved by modulation of LXRalpha phosphorylation. Under basal conditions, LXRalpha is phosphorylated...

Authors: Torra IP, Ismaili N, Feig JE, Xu CF, Cavasotto C, Pancratov R, Rogatsky I, Neubert TA, Fisher EA,...

Critical role for transcription factor C/EBP-beta in regulating the expression of death-associated protein kinase 1

Transcription factor C/EBP-beta regulates a number of physiologic responses. During an investigation of the growth-suppressive effects of IFNs, we noticed that cebpb (-/-) cells fail to undergo apoptosis upon IFN-gamma treatment compared to the...

Authors: Gade P, Roy SK, Li H, Nallar SC, Kalvakolanu DV

The Microtubule-severing Proteins Spastin and Katanin Participate Differently in the Formation of Axonal Branches

Neurons express two different microtubule-severing proteins, namely P60-katanin and spastin. Here, we performed studies on cultured neurons to ascertain whether these two proteins participate differently in axonal branch formation. P60-katanin is...

Authors: Yu W, Qiang L, Solowska JM, Karabay A, Korulu S, Baas PW

Sleeping Beauty Transposon-mediated Engineering of Human Primary T Cells for Therapy of CD19(+) Lymphoid Malignancies

We have reported earlier that the non-viral Sleeping Beauty (SB) transposon system can mediate genomic integration and long-term reporter gene expression in human primary peripheral blood (PB) T cells. In order to test whether this system can be used...

Authors: Huang X, Guo H, Kang J, Choi S, Zhou TC, Tammana S, Lees CJ, Li ZZ, Milone M, Levine BL, Tolar J,...

SST Peer Reviewed

Expression of angiotensin converting enzyme changes MHC class I peptide presentation by modifying C-termini of peptide precursors

We recently reported a mouse model called ACE 10/10 in which macrophages over express the carboxypeptidase angiotensin converting enzyme (ACE). These mice have an enhanced inflammatory response to tumors that markedly inhibits tumor growth. Here, we...

Authors: Shen XZ, Lukacher AE, Williams IR, Bernstein KE

Pepsinogen C proteolytic processing of surfactant protein B

Surfactant protein B is essential to the function of pulmonary surfactant and to lamellar body genesis in alveolar epithelial type 2 cells. The bioactive, mature SP-B is derived from multi-step post-translational proteolysis of a larger proprotein....

Authors: Gerson KD, Foster CD, Zhang P, Zhang Z, Rosenblatt MM, Guttentag SH

SST Peer Reviewed

NF-kappaB-mediated activation of the chemokine CCL22 by the product of the human cytomegalovirus gene UL144 escapes regulation by viral IE86

The product of the human cytomegalovirus (HCMV) gene UL144, expressed at early times postinfection, is located in the UL/b' region of the viral genome and is related to members of the tumor necrosis factor receptor superfamily, but it does not bind...

Authors: Poole E, Atkins E, Nakayama T, Yoshie O, Groves I, Alcami A, Sinclair J

Filamin A Stabilizes Fc-gamma-RI Surface Expression and Prevents Its Lysosomal Routing

Filamin A, or actin-binding protein 280, is a ubiquitously expressed cytosolic protein that interacts with intracellular domains of multiple receptors to control their subcellular distribution, and signaling capacity. In this study, we document...

Authors: Beekman JM, van der Poel CE, van der Linden JA, van den Berg DL, van den Berghe PV, van de Winkel...

Tumor Cell Killing Mechanisms of Epidermal Growth Factor Receptor (EGFR) Antibodies Are Not Affected by Lung Cancer-Associated EGFR Kinase Mutations

The epidermal growth factor receptor (EGFR) serves as a molecular target for novel cancer therapeutics such as tyrosine kinase inhibitors (TKI) and EGFR Abs. Recently, specific mutations in the EGFR kinase domain of lung cancers were identified,...

Authors: Peipp M, Schneider-Merck T, Dechant M, Beyer T, Lammerts van Bueren JJ, Bleeker WK, Parren PW, van...

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