Search Results

Interaction of syntenin-1 and the NG2 proteoglycan in migratory oligodendrocyte precursor cells

Migration of oligodendrocyte precursors along axons is a necessary prerequisite for myelination, but little is known about underlying mechanisms. NG2 is a large membrane proteoglycan implicated in oligodendrocyte migration. Here we show that a PDZ...

Authors: Chatterjee N, Stegmüller J, Schätzle P, Karram K, Koroll M, Werner HB, Nave KA, Trotter J

Nitric oxide-p38 MAPK signaling stabilizes mRNA through AU-rich element-dependent and -independent mechanisms

Regulation of mRNA stability by p38 MAPK has been linked to adenosine-uridine-rich elements (AURE) within the 3;-untranslated region (3;UTR) of mRNA. Using microarrays, we previously found that AURE-containing mRNA is over-represented among...

Authors: Wang S, Zhang J, Zhang Y, Kern S, Danner RL

Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses Rho GTPases in human brain microvascular endothelial cells and inhibits adhesion and transendothelial migration of HIV-1 infected monocytes

Under inflammatory conditions (including HIV-1 encephalitis and multiple sclerosis), activated brain endothelium enhances the adhesion and transmigration of monocytes across the blood-brain barrier (BBB). Synthetic ligands that activate the...

Authors: Ramirez SH, Heilman D, Morsey B, Potula R, Haorah J, Persidsky Y

A peptide that ameliorates lupus up-regulates the diminished expression of early growth response factors 2 and 3

Expansion of autoreactive T cells and their resistance to anergy was demonstrated in systemic lupus erythematosus (SLE). A pair of transcription factors, early growth response 2 (Egr-2) and 3 (Egr-3), are negative regulators of T cell activation that...

Authors: Sela U, Dayan M, Hershkoviz R, Lider O, Mozes E

Thiopental protects human T lymphocytes from apoptosis in vitro via the expression of heat shock protein 70

Barbiturates, which are used for the treatment of intracranial hypertension after severe head injury, have been associated with anti-inflammatory side effects. While all barbiturates inhibit T cell function, only thiobarbiturates markedly reduce the...

Authors: Roesslein M, Schibilsky D, Muller L, Goebel U, Schwer C, Humar M, Schmidt R, Geiger KK, Pahl HL,...

SST Peer Reviewed

Bone marrow stroma confers resistance to Apo2 ligand/TRAIL in multiple myeloma in part by regulating c-FLIP

Apo2 ligand (Apo2L)/TRAIL induces apoptosis of cancer cells that express the specific receptors while sparing normal cells. Because the tumor microenvironment protects myeloma from chemotherapy, we investigated whether hemopoietic stroma induces...

Authors: Perez LE, Parquet N, Shain K, Nimmanapalli R, Alsina M, Anasetti C, Dalton W

Nonvirally Engineered Porcine Adipose Tissue-Derived Stem Cells: Use in Posterior Spinal Fusion

Multiple factors alter intervertebral disc volume, structure, shape, composition, and biomechanical properties, often leading to low back pain. Spinal fusion is frequently performed to treat this problem. We recently published results of our...

Authors: Sheyn D, Pelled G, Zilberman Y, Talasazan F, Frank JM, Gazit D, Gazit Z

SST Peer Reviewed

Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission

Transmission of HIV-1 via intercellular connections has been estimated as 100-1000 times more efficient than a cell-free process, perhaps in part explaining persistent viral spread in the presence of neutralizing antibodies. Such effective...

Authors: Sowinski S, Jolly C, Berninghausen O, Purbhoo MA, Chauveau A, Köhler K, Oddos S, Eissmann P, Brodsky...

MicroRNA-21 Increases Aldosterone Secretion and Proliferation in H295R Human Adrenocortical Cells

MicroRNAs (miRNAs) are endogenous small non-coding RNAs which decrease the expression levels of specific genes by translational repression, sequestration and degradation of their mRNAs. Angiotensin II is an important modulator of adrenal zona...

Authors: Romero DG, Plonczynski MW, Carvajal CA, Gomez-Sanchez EP, Gomez-Sanchez CE

CD30-induced signaling is absent in Hodgkin's cells but present in anaplastic large cell lymphoma cells

High CD30 expression in classical Hodgkin's lymphoma and anaplastic large cell lymphoma (ALCL) suggests an important pathogenic role of this cytokine receptor. To test this hypothesis, we investigated CD30 signaling in Hodgkin's and ALCL cell lines...

Authors: Hirsch B, Hummel M, Bentink S, Fouladi F, Spang R, Zollinger R, Stein H, Dürkop H

SST Peer Reviewed

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Interaction of syntenin-1 and the NG2 proteoglycan in migratory oligodendrocyte precursor cells

Nitric oxide-p38 MAPK signaling stabilizes mRNA through AU-rich element-dependent and -independent mechanisms

Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses Rho GTPases in human brain microvascular endothelial cells and inhibits adhesion and transendothelial migration of HIV-1 infected monocytes

A peptide that ameliorates lupus up-regulates the diminished expression of early growth response factors 2 and 3

Thiopental protects human T lymphocytes from apoptosis in vitro via the expression of heat shock protein 70

Bone marrow stroma confers resistance to Apo2 ligand/TRAIL in multiple myeloma in part by regulating c-FLIP

Nonvirally Engineered Porcine Adipose Tissue-Derived Stem Cells: Use in Posterior Spinal Fusion

Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission

MicroRNA-21 Increases Aldosterone Secretion and Proliferation in H295R Human Adrenocortical Cells

CD30-induced signaling is absent in Hodgkin's cells but present in anaplastic large cell lymphoma cells