Search Results

The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases

Eph receptors play critical roles in the establishment and remodeling of neuronal connections, but the signaling pathways involved are not fully understood. We have identified a novel interaction between the C terminus of the EphA4 receptor and the...

Authors: Richter M, Murai KK, Bourgin C, Pak DT, Pasquale EB

Pluripotency of a Single Spermatogonial Stem Cell in Mice

Although pluripotent stem cells were recently discovered in postnatal testis, attempts to analyze their developmental potential have led to conflicting claims that spermatogonial stem cells are pluripotent or that they lose spermatogenic potential...

Authors: Kanatsu-Shinohara M, Lee J, Inoue K, Ogonuki N, Miki H, Toyokuni S, Ikawa M, Nakamura T, Ogura A,...

SST Peer Reviewed

cAMP/PKA Regulates Osteogenesis, Adipogenesis and Ratio of RANKL/OPG mRNA Expression in Mesenchymal Stem Cells by Suppressing Leptin

BACKGROUND: Mesenchymal stem cells (MSCs) are a pluripotent cell type that can differentiate into adipocytes, osteoblasts and other cells. The reciprocal relationship between adipogenesis and osteogenesis was previously demonstrated; however, the...

Authors: Yang DC, Tsay HJ, Lin SY, Chiou SH, Li MJ, Chang TJ, Hung SC

Binding of the P2Y2 Nucleotide Receptor to Filamin A Regulates Migration of Vascular Smooth Muscle Cells

The functional expression of the G protein-coupled P2Y2 nucleotide receptor (P2Y2R) has been associated with proliferation and migration of vascular smooth muscle cells (SMCs), 2 processes involved in atherosclerosis and restenosis. Activation of the...

Authors: Yu N, Erb L, Shivaji R, Weisman GA, Seye CI

Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities

Rapamycin is an immunosuppressive immunophilin ligand reported as having neurotrophic activity. We show that modification of rapamycin at the mammalian target of rapamycin (mTOR) binding region yields immunophilin ligands, WYE-592 and ILS-920, with...

Authors: Ruan B, Pong K, Jow F, Bowlby M, Crozier RA, Liu D, Liang S, Chen Y, Mercado ML, Feng X, Bennett F,...

SST Peer Reviewed

IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis

Expression of IL-22 is induced in several human inflammatory conditions, including inflammatory bowel disease (IBD). Expression of the IL-22 receptor is restricted to innate immune cells; however, the role of IL-22 in colitis has not yet been...

Authors: Sugimoto K, Ogawa A, Mizoguchi E, Shimomura Y, Andoh A, Bhan AK, Blumberg RS, Xavier RJ, Mizoguchi...

Dual Regulation of Cofilin Activity by LIM Kinase and Slingshot-1L Phosphatase Controls Platelet-Derived Growth Factor Induced Migration of Human Aortic Smooth Muscle Cells

Platelet-derived growth factor (PDGF) plays a central role in vascular healing, atherosclerosis and restenosis, partly by stimulating vascular smooth muscle cell (VSMC) migration. Migration requires rapid turnover of actin filaments, which is...

Authors: San Martin A, Lee MY, Williams HC, Mizuno K, Lassègue B, Griendling KK

Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration

Precise spatial and temporal regulation of cell adhesion and de-adhesion is critical for dynamic lymphocyte migration. Although a great deal of information has been learned about integrin lymphocyte function-associated antigen (LFA)-1 adhesion, the...

Authors: Morin NA, Oakes PW, Hyun YM, Lee D, Chin EY, King MR, Springer TA, Shimaoka M, Tang JX, Reichner JS,...

CRE recombinase-based positive-negative selection systems for genetic manipulation in Trypanosoma brucei

The limited repertoire of drug-resistance markers imposes a serious obstacle to genetic manipulation of Trypanosoma brucei. Here we describe experiments with a fusion protein that allows positive selection for genome integration followed by CRE...

Authors: Scahill MD, Pastar I, Cross GA

CtBP is an essential corepressor for BCL6 autoregulation

The transcription repressor BCL6 plays an essential role in the formation and function of germinal center (GC). While normal B cells promptly shut off BCL6 when they exit GC, many GC-derived B cell lymphomas sustain BCL6 expression through...

Authors: Mendez LM, Polo JM, Yu JJ, Krupski M, Ding BB, Melnick A, Ye BH

SST Peer Reviewed

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The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases

Pluripotency of a Single Spermatogonial Stem Cell in Mice

cAMP/PKA Regulates Osteogenesis, Adipogenesis and Ratio of RANKL/OPG mRNA Expression in Mesenchymal Stem Cells by Suppressing Leptin

Binding of the P2Y2 Nucleotide Receptor to Filamin A Regulates Migration of Vascular Smooth Muscle Cells

Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities

IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis

Dual Regulation of Cofilin Activity by LIM Kinase and Slingshot-1L Phosphatase Controls Platelet-Derived Growth Factor Induced Migration of Human Aortic Smooth Muscle Cells

Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration

CRE recombinase-based positive-negative selection systems for genetic manipulation in Trypanosoma brucei

CtBP is an essential corepressor for BCL6 autoregulation