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Inorganic pyrophosphate generation by TGF-beta1 is mainly dependent on ANK induction by Ras/Raf-1/ERK pathways in chondrocytes

ANK is a multipass transmembrane protein transporter, thought to play a role in the export of intracellular inorganic pyrophosphate (iPPi), and so to contribute to the pathophysiology of chondrocalcinosis. As TGF-beta1 was shown to favour calcium...

Authors: Cailotto F, Bianchi A, Sebillaud S, Venkatesan N, Moulin D, Jouzeau JY, Netter P

Regulation of human DAP10 gene expression in NK and T cells by Ap-1 transcription factors

Human NKG2D/DAP10 is an activation receptor expressed by NK and subsets of T cells, whose ligands include MHC class I chain-related (MIC) protein A and protein B and UL16-binding proteins that are often up-regulated by stress or pathological...

Authors: Marusina AI, Burgess SJ, Pathmanathan I, Borrego F, Coligan JE

Downregulation of Monocyte Chemoattractant Protein-1 Involving Short Interfering RNA Attenuates Hapten-induced Contact Hypersensitivity

Contact hypersensitivity (CHS) is a common skin disease, presenting clinically as allergic contact dermatitis. At inflammatory sites in a typical CHS model in the mouse ear, elevated expression of monocyte chemoattractant protein-1 (MCP-1) has been...

Authors: Ishimoto T, Takei Y, Yuzawa Y, Hanai K, Nagahara S, Tarumi Y, Matsuo S, Kadomatsu K

Recombinant interleukin-24 lacks apoptosis-inducing properties in melanoma cells

IL-24, also known as melanoma differentiation antigen 7 (mda-7), is a member of the IL-10 family of cytokines and is mainly produced by Th(2) cells as well as by activated monocytes. Binding of IL-24 to either of its two possible heterodimeric...

Authors: Kreis S, Philippidou D, Margue C, Rolvering C, Haan C, Dumoutier L, Renauld JC, Behrmann I

Mechanism of Inducible Nitric Oxide Synthase Exclusion from Mycobacterial Phagosomes

Mycobacterium tuberculosis is sensitive to nitric oxide generated by inducible nitric oxide synthase (iNOS). Consequently, to ensure its survival in macrophages, M. tuberculosis inhibits iNOS recruitment to its phagosome by an unknown mechanism. Here...

Authors: Davis AS, Vergne I, Master SS, Kyei GB, Chua J, Deretic V

4-1BBL Induces TNF Receptor-Associated Factor 1-Dependent Bim Modulation in Human T Cells and Is a Critical Component in the Costimulation-Dependent Rescue of Functionally Impaired HIV-Specific CD8 T Cells

During chronic infection, HIV-specific CD8 T cells exhibit progressive signs of functional impairment, attributed to persistent antigenic stimulation, up-regulation of the inhibitory receptor PD-1, and declining T cell help. Strategies that directly...

Authors: Wang C, Wen T, Routy JP, Bernard NF, Sekaly RP, Watts TH

Role of Epac1, an Exchange Factor for Rap GTPases, in Endothelial Microtubule Dynamics and Barrier Function

Rap1 GTPase activation by its cAMP responsive nucleotide exchange factor Epac present in endothelial cells increases endothelial cell barrier function with an associated increase in cortical actin. Here, Epac1 was shown to be responsible for these...

Authors: Sehrawat S, Cullere X, Patel S, Italiano J Jr, Mayadas TN

Expression of androgen receptor is negatively regulated by p53

Increased expression of androgen receptor (AR) in prostate cancer (PC) is associated with transition to androgen independence. Because the progression of PC to advanced stages is often associated with the loss of p53 function, we tested whether the...

Authors: Alimirah F, Panchanathan R, Chen J, Zhang X, Ho SM, Choubey D

Cooperative binding of the MHC-I cytoplasmic domain and HIV-1 Nef to the endosomal AP-1 complex via its micro subunit

HIV-1 Nef provides immune evasion by decreasing the expression of MHC-I at the surface of infected cells. The endosomal clathrin adaptor protein complex AP-1 is a key cellular cofactor for this activity, and it is recruited to the MHC-I cytoplasmic...

Authors: Noviello CM, Benichou S, Guatelli JC

Latent membrane protein 2B regulates susceptibility to induction of lytic Epstein-Barr virus infection

The B-lymphotropic Epstein-Barr virus (EBV) encodes two isoforms of the latent membrane protein 2 (LMP2), LMP2A and LMP2B, which are expressed during latency in B-cells. The function of LMP2B is largely unknown, whereas LMP2A blocks B-cell receptor...

Authors: Rechsteiner MP, Berger C, Zauner L, Sigrist JA, Weber M, Longnecker R, Bernasconi M, Nadal D

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