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Interaction of syntenin-1 and the NG2 proteoglycan in migratory oligodendrocyte precursor cells

Migration of oligodendrocyte precursors along axons is a necessary prerequisite for myelination, but little is known about underlying mechanisms. NG2 is a large membrane proteoglycan implicated in oligodendrocyte migration. Here we show that a PDZ...

Authors: Chatterjee N, Stegmüller J, Schätzle P, Karram K, Koroll M, Werner HB, Nave KA, Trotter J

Rapid tumor necrosis factor alpha-induced exocytosis of glutamate receptor 2-lacking AMPA receptors to extrasynaptic plasma membrane potentiates excitotoxicity

The postinjury inflammatory response in the CNS leads to neuronal excitotoxicity. Our previous studies show that a major component of this response, the inflammatory cytokine tumor necrosis factor alpha (TNFalpha), causes a rapid increase in AMPA...

Authors: Leonoudakis D, Zhao P, Beattie EC

Nitric oxide-p38 MAPK signaling stabilizes mRNA through AU-rich element-dependent and -independent mechanisms

Regulation of mRNA stability by p38 MAPK has been linked to adenosine-uridine-rich elements (AURE) within the 3;-untranslated region (3;UTR) of mRNA. Using microarrays, we previously found that AURE-containing mRNA is over-represented among...

Authors: Wang S, Zhang J, Zhang Y, Kern S, Danner RL

Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia

Spastin and P60-katanin are two distinct microtubule-severing proteins. Autosomal dominant mutations in the SPG4 locus corresponding to spastin are the most common cause of hereditary spastic paraplegia (HSP), a neurodegenerative disease that...

Authors: Solowska JM, Morfini G, Falnikar A, Himes BT, Brady ST, Huang D, Baas PW

Thiopental protects human T lymphocytes from apoptosis in vitro via the expression of heat shock protein 70

Barbiturates, which are used for the treatment of intracranial hypertension after severe head injury, have been associated with anti-inflammatory side effects. While all barbiturates inhibit T cell function, only thiobarbiturates markedly reduce the...

Authors: Roesslein M, Schibilsky D, Muller L, Goebel U, Schwer C, Humar M, Schmidt R, Geiger KK, Pahl HL,...

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Trypanosoma cruzi

Causative agent of American trypanosomiasis (Chagas disease). In humans found as both an intracellular form, the amastigote, and as a trypomastigote form in the blood. Chagas disease affects primarily the nervous system and heart.

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J774A.1

macrophage cell line

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CCRF-CEM

acute lymphoblastic leukemia cell line, T-lymphoblast

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32D

lymphoblast, established from long-term bone marrow cultures of C3H/HeJ mice infected with the Friend murine leukemia virus. Morphology: mostly round cells growing singly or in small clusters in suspension, some cells are loosely adherent.

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RAW 264.7

Macrophage cell line established from a tumor induced by Abelson murine leukemia virus in male adult BALB/c mouse.

See Transfection Data

Data Type

Category

Research Area

Platform

Topic

Species

Characteristic

Format

Origin

Interaction of syntenin-1 and the NG2 proteoglycan in migratory oligodendrocyte precursor cells

Rapid tumor necrosis factor alpha-induced exocytosis of glutamate receptor 2-lacking AMPA receptors to extrasynaptic plasma membrane potentiates excitotoxicity

Nitric oxide-p38 MAPK signaling stabilizes mRNA through AU-rich element-dependent and -independent mechanisms

Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia

Thiopental protects human T lymphocytes from apoptosis in vitro via the expression of heat shock protein 70

Trypanosoma cruzi

J774A.1

CCRF-CEM

32D

RAW 264.7