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High CD21 expression inhibits internalization of anti-CD19 antibodies and cytotoxicity of an anti-CD19-drug conjugate

CD19 and CD21 (CR2) are co-receptors found on B-cells and various B-cell lymphomas, including non-Hodgkin lymphoma. To evaluate their suitability as targets for therapy of such lymphomas using internalization-dependent antibody-drug conjugates [such...

Authors: Ingle GS, Chan P, Elliott JM, Chang WS, Koeppen H, Stephan JP, Scales SJ

Cytokines induce an early steroid resistance in airway smooth muscle cells: novel role of interferon regulatory factor-1

We have previously shown that long-term treatment of airway smooth muscle (ASM) cells with a combination of TNFalpha and IFNgamma impaired steroid anti-inflammatory action through the upregulation of glucocorticoid receptor beta isoform (GRbeta) (Mol...

Authors: Tliba O, Damera G, Banerjee A, Gu S, Baidouri H, Keslacy S, Amrani Y

Differential Activities of Glucocorticoid-induced Leucine Zipper Protein Isoforms

Glucocorticoid-induced leucine zipper protein (GILZ) is expressed in both epithelial and immune tissues and modulates a variety of cellular functions, including proliferation and epithelial sodium channel (ENaC) activity. A number of reports have...

Authors: Soundararajan R, Wang J, Melters DP, Pearce D

Mechanism of All-Trans Retinoic Acid Effect on Tumor-Associated Myeloid-Derived Suppressor Cells

Myeloid-derived suppressor cells (MDSC) play an important role in tumor escape by suppressing T-cell responses. MDSC represent a group of cells of myeloid lineage at different stages of differentiation. Increased arginase activity and production of...

Authors: Nefedova Y, Fishman M, Sherman S, Wang X, Beg AA, Gabrilovich DI

Identification of NCAM-binding peptides promoting neurite outgrowth via a heterotrimeric G-protein-coupled pathway

A combinatorial library of undecapeptides was produced and utilized for the isolation of peptide binding to the fibronectin type 3 modules (F3I-F3II) of the neural cell adhesion molecule (NCAM). The isolated peptides were sequenced and produced as...

Authors: Hansen RK, Christensen C, Korshunova I, Kriebel M, Burkarth N, Kiselyov VV, Olsen M, Ostergaard S,...

Activation of Hepatic Stem Cell Marker EpCAM by Wnt beta-Catenin Signaling in Hepatocellular Carcinoma

The heterogeneous nature of hepatocellular carcinoma (HCC) and the lack of appropriate biomarkers have hampered patient prognosis and treatment stratification. Using a gene expression profiling approach, we recently identified a novel prognostic HCC...

Authors: Yamashita T, Budhu A, Forgues M, Wang XW

Requirements for cellular co-trafficking of factor VIII and von Willebrand factor to Weibel-Palade bodies

BACKGROUND: von Willebrand factor (VWF) serves a critical role as a carrier of factor (F)VIII in circulation. While it is generally believed that FVIII and VWF assemble in circulation after secretion from different cells, an alternative view is that...

Authors: van den Biggelaar M, Bierings R, Storm G, Voorberg J, Mertens K

Rac1 and Rac2 differentially regulate actin free barbed end formation downstream of the fMLP receptor

Actin assembly at the leading edge of migrating cells depends on the availability of high-affinity free barbed ends (FBE) that drive actin filament elongation and subsequent membrane protrusion. We investigated the specific mechanisms through which...

Authors: Sun CX, Magalhaes MA, Glogauer M

16-kDa Prolactin Inhibits Endothelial Cell Migration by Down-Regulating the Ras-Tiam1-Rac1-Pak1 Signaling Pathway

Angiogenesis plays a key role in promoting tumorigenesis and metastasis. The 16-kDa fragment of prolactin (16k PRL) is an NH(2)-terminal natural breakdown fragment of the intact 23-kDa prolactin and has been shown to have potent antiangiogenic and...

Authors: Lee SH, Kunz J, Lin SH, Yu-Lee LY

KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions

Cerebral cavernous malformation (CCM), a disease associated with defective endothelial junctions, result from autosomal dominant CCM1 mutations that cause loss of KRIT-1 protein function, though how the loss of KRIT-1 leads to CCM is obscure. KRIT-1...

Authors: Glading A, Han J, Stockton RA, Ginsberg MH

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