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Phosphorylation of LXR alpha Selectively Regulates Target Gene Expression in Macrophages

Dysregulation of LXRalpha activity has been linked to cardiovascular and metabolic diseases. Here, we show that LXRalpha target gene selectivity is achieved by modulation of LXRalpha phosphorylation. Under basal conditions, LXRalpha is phosphorylated...

Authors: Torra IP, Ismaili N, Feig JE, Xu CF, Cavasotto C, Pancratov R, Rogatsky I, Neubert TA, Fisher EA,...

Trefoil Factor 3 Stimulates Human and Rodent Pancreatic Islet beta-Cell Replication with Retention of Function

Both major forms of diabetes involve a decline in beta-cell mass, mediated by autoimmune destruction of insulin-producing cells in type 1 diabetes and by increased rates of apoptosis secondary to metabolic stress in type 2 diabetes. Methods for...

Authors: Fueger PT, Schisler JS, Lu D, Babu DA, Mirmira RG, Newgard CB, Hohmeier HE

Critical role for transcription factor C/EBP-beta in regulating the expression of death-associated protein kinase 1

Transcription factor C/EBP-beta regulates a number of physiologic responses. During an investigation of the growth-suppressive effects of IFNs, we noticed that cebpb (-/-) cells fail to undergo apoptosis upon IFN-gamma treatment compared to the...

Authors: Gade P, Roy SK, Li H, Nallar SC, Kalvakolanu DV

PICOT Attenuates Cardiac Hypertrophy by Disrupting Calcineurin-NFAT Signaling

PICOT (protein kinase C-interacting cousin of thioredoxin) was previously shown to inhibit pressure overload-induced cardiac hypertrophy, concomitant with an increase in ventricular function and cardiomyocyte contractility. The combined analyses of...

Authors: Jeong D, Kim JM, Cha H, Oh JG, Park J, Yun SH, Ju ES, Jeon ES, Hajjar RJ, Park WJ

Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration

Precise spatial and temporal regulation of cell adhesion and de-adhesion is critical for dynamic lymphocyte migration. Although a great deal of information has been learned about integrin lymphocyte function-associated antigen (LFA)-1 adhesion, the...

Authors: Morin NA, Oakes PW, Hyun YM, Lee D, Chin EY, King MR, Springer TA, Shimaoka M, Tang JX, Reichner JS,...

FK506 binding protein mediates glioma cell growth and sensitivity to rapamycin treatment by regulating NF-kappaB signaling pathway

FK506 binding protein 5 (FKBP5) belongs to a family of immunophilins named for their ability to bind immunosuppressive drugs, also known as peptidyl-prolyl cis-trans isomerases, and also with chaperones to help protein folding. Using glioma cDNA...

Authors: Jiang W, Cazacu S, Xiang C, Zenklusen JC, Fine HA, Berens M, Armstrong B, Brodie C, Mikkelsen T

Expression of angiotensin converting enzyme changes MHC class I peptide presentation by modifying C-termini of peptide precursors

We recently reported a mouse model called ACE 10/10 in which macrophages over express the carboxypeptidase angiotensin converting enzyme (ACE). These mice have an enhanced inflammatory response to tumors that markedly inhibits tumor growth. Here, we...

Authors: Shen XZ, Lukacher AE, Williams IR, Bernstein KE

CtBP is an essential corepressor for BCL6 autoregulation

The transcription repressor BCL6 plays an essential role in the formation and function of germinal center (GC). While normal B cells promptly shut off BCL6 when they exit GC, many GC-derived B cell lymphomas sustain BCL6 expression through...

Authors: Mendez LM, Polo JM, Yu JJ, Krupski M, Ding BB, Melnick A, Ye BH

SST Peer Reviewed

Pepsinogen C proteolytic processing of surfactant protein B

Surfactant protein B is essential to the function of pulmonary surfactant and to lamellar body genesis in alveolar epithelial type 2 cells. The bioactive, mature SP-B is derived from multi-step post-translational proteolysis of a larger proprotein....

Authors: Gerson KD, Foster CD, Zhang P, Zhang Z, Rosenblatt MM, Guttentag SH

SST Peer Reviewed

The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment

During vertebrate cell division, chromosomes oscillate with periods of smooth motion interrupted by abrupt reversals in direction. These oscillations must be spatially constrained in order to align and segregate chromosomes with high fidelity, but...

Authors: Stumpff J, von Dassow G, Wagenbach M, Asbury C, Wordeman L

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