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Advanced Glycation End Products (AGEs) Cause Pro-atherogenic Changes in Cholesterol Transport: A Possible Mechanism for Cardiovascular Risk in Diabetes

Purpose of Study: Hyperglycemia is the major cause of diabetic vascular complications. AGEs accumulate under hyperglycemic conditions and contribute to atherosclerosis. ATP binding cassette transporters (ABC) A1, G1, and cholesterol 27-hydroxylase...

Authors: Gamez, JD, Voloshyna I, Littlefield MJ, Castro-Magana M, Reiss AB

SST Peer Reviewed

Structure-activity relationships of benzbromarone metabolites and derivatives as EYA inhibitory anti-angiogenic agents

The tyrosine phosphatase activity of the phosphatase-transactivator protein Eyes Absent (EYA) is angiogenic through its roles in endothelial cell migration and tube formation. Benzbromarone, a known anti-gout agent, was previously identified as an...

Authors: Pandey RN, Wang TS, Tadjuidje E, McDonald MG, Rettie AE, Hegde RS

Cell density impacts epigenetic regulation of cytokine-induced E-selectin gene expression in vascular endothelium

Growing evidence suggests that the phenotype of endothelial cells during angiogenesis differs from that of quiescent endothelial cells, although little is known regarding the difference in the susceptibility to inflammation between both the...

Authors: Hamada K, Osaka M, Yoshida M

Targeting uPAR with antagonistic recombinant human antibodies in aggressive breast cancer

Components of the plasminogen activation system, which are overexpressed in aggressive breast cancer subtypes, offer appealing targets for development of new diagnostics and therapeutics. By comparing gene expression data in patient populations and...

Authors: LeBeau AM, Duriseti S, Murphy ST, Pepin F, Hann B, Gray JW, VanBrocklin HF, Craik CS

Rap1 and Rap2 antagonistically control endothelial barrier resistance

Rap1 and Rap2 are closely related proteins of the Ras family of small G-proteins. Rap1 is well known to regulate cell-cell adhesion. Here, we have analysed the effect of Rap-mediated signalling on endothelial permeability using electrical impedance...

Authors: Pannekoek WJ, Linnemann JR, Brouwer PM, Bos JL, Rehmann H

LAT1 is a central transporter of essential amino acids in human umbilical vein endothelial cells

Endothelial cell proliferation supporting angiogenesis requires sufficient nutrient supply because of facilitated intracellular metabolism. However, little is known about the mechanism for the promotion of nutrient incorporation in proliferating...

Authors: Hayashi K, Jutabha P, Kamai T, Endou H, Anzai N

TGF-ß mediates homing of bone marrow-derived human mesenchymal stem cells to glioma stem cells

Although studies have suggested that bone marrow human mesenchymal stem cells (BM-hMSC) may be used as delivery vehicles for cancer therapy, it remains unclear whether BM-hMSCs are capable of targeting cancer stem cells, including glioma stem cells...

Authors: Shinojima N, Hossain A, Takezaki T, Fueyo J, Gumin J, Gao F, Nwajei F, Marini FC, Andreeff M,...

Effects of the dual TP receptor antagonist and thromboxane synthase inhibitor EV-077 on human endothelial and vascular smooth muscle cells

The prothrombotic mediator thromboxane A2 is derived from arachidonic acid metabolism through the cyclooxygenase and thromboxane synthase pathways, and transduces its effect through the thromboxane prostanoid (TP) receptor. The aim of this study was...

Authors: Petri MH, Tellier C, Michiels C, Ellertsen I, Dogné JM, Bäck M

Passage-dependent cancerous transformation of human mesenchymal stem cells under carcinogenic hypoxia

Bone marrow-derived human mesenchymal stem cells (hMSCs) either promote or inhibit cancer progression, depending on factors that heretofore have been undefined. Here we have utilized extreme hypoxia (0.5% O2) and concurrent treatment with metal...

Authors: Crowder SW, Horton LW, Lee SH, McClain CM, Hawkins OE, Palmer AM, Bae H, Richmond A, Sung HJ

Evaluation of a whole-blood cytokine release assay for use in measuring endotoxin activity of group B Neisseria meningitidis vaccines made from lipid A acylation mutants.

Bacterial endotoxin interacts with the human immune system via complex immunological pathways. The evaluation of endotoxicity is important in the development of safe vaccines and immunomodulatory therapeutics. The Limulus amebocyte lysate (LAL) assay...

Authors: Stoddard MB, Pinto V, Keiser PB, Zollinger W.

SST Peer Reviewed

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