Search Results

A 3D cartilage - inflammatory cell culture system for the modeling of human osteoarthritis

Inflammation plays a major role in the destruction of cartilage in osteoarthritis (OA), with the interaction of multiple mediators, immune cells, fibroblasts and chondrocytes. Current 2D studies in vitro with cell lines, as well as animal models, are...

Authors: Sun L, Wang X, Kaplan DL.

Slow receptor dissociation kinetics differentiate macitentan from other endothelin receptor antagonists in pulmonary arterial smooth muscle cells

Two endothelin receptor antagonists (ERAs), bosentan and ambrisentan, are currently approved for the treatment of pulmonary arterial hypertension (PAH), a devastating disease involving an activated endothelin system and aberrant contraction and...

Authors: Gatfield J, Mueller Grandjean C, Sasse T, Clozel M, Nayler O

Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator expression

AIMS: Stimulated release of tissue-type plasminogen activator (t-PA) is pivotal for an intravascular fibrinolytic response and protects the circulation from occluding thrombosis. Hence, an impaired t-PA production is associated with increased risk...

Authors: Larsson P, Ulfhammer E, Magnusson M, Bergh N, Lunke S, El-Osta A, Medcalf RL, Svensson PA, Karlsson...

A role for VEGFR2 activation in endothelial responses caused by barrier disruptive OxPAPC concentrations.

INTRODUCTION: Oxidation products of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphatidylcholine (OxPAPC) differentially modulate endothelial cell (EC) barrier function in a dose-dependent fashion. Vascular endothelial growth factor receptor-2...

Authors: Birukova AA, Lee S, Starosta V, Wu T, Ho T, Kim J, Berliner JA, Birukov KG.

Genistein cooperates with the histone deacetylase inhibitor vorinostat to induce cell death in prostate cancer cells.

BACKGROUND: Among American men, prostate cancer is the most common, non-cutaneous malignancy that accounted for an estimated 241,000 new cases and 34,000 deaths in 2011. Previous studies have suggested that Wnt pathway inhibitory genes are silenced...

Authors: Phillip CJ, Giardina CK, Bilir B, Cutler DJ, Lai YH, Kucuk O, Moreno CS.

Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways

Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine and a selective inducer of apoptosis in a range of tumour cells, but not in normal, untransformed cells. A large number of chemotherapeutics as well as biological agents...

Authors: van Dijk M, Halpin-McCormick A, Sessler T, Samali A, Szegezdi E

Data Type

Category

Research Area

Platform

Topic

Species

Characteristic

Format

Origin

A 3D cartilage - inflammatory cell culture system for the modeling of human osteoarthritis

Slow receptor dissociation kinetics differentiate macitentan from other endothelin receptor antagonists in pulmonary arterial smooth muscle cells

Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator expression

A role for VEGFR2 activation in endothelial responses caused by barrier disruptive OxPAPC concentrations.

Genistein cooperates with the histone deacetylase inhibitor vorinostat to induce cell death in prostate cancer cells.

Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways

Dimeric naphthoquinones, a novel class of compounds with prostate cancer cytotoxicity.

Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells.

Regulation of lymphatic-blood vessel separation by endothelial Rac1

Measurement of local permeability at subcellular level in cell models of agonist- and ventilator-induced lung injury.