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PPAR? regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity

RATIONALE: Activation of peroxisome proliferator-activated receptor-? (PPAR?) by thiazolidinediones lowers blood pressure, whereas PPAR? mutations cause hypertension. Previous studies suggest these effects may be mediated through the vasculature, but...

Authors: Ketsawatsomkron P, Lorca RA, Keen HL, Weatherford ET, Liu X, Pelham CJ, Grobe JL, Faraci FM, England...

SST Peer Reviewed

Arginine deficiency augments inflammatory mediator production by airway epithelial cells in vitro.

BACKGROUND: Previously we showed that reduced availability of the essential amino acid tryptophan per se attenuates post-transcriptional control of interleukin (IL)-6 and IL-8 leading to hyperresponsive production of these inflammatory mediators by...

Authors: Fan XY, van den Berg A, Snoek M, van der Flier LG, Smids B, Jansen HM, Liu RY, Lutter R.

High-efficiency transfection and survival rates of embryonic and adult mouse neural stem cells achieved by electroporation.

Cells of the central nervous system are notoriously difficult to transfect. This is not only true for neurons and glial cells but also for dividing neural stem and progenitor cells (NSCs). About ten years ago a major advance was provided by...

Authors: Bertram B, Wiese S, von Holst A

SST Peer Reviewed

Oxygen and the liberation of placental factors responsible for vascular compromise

Maternal endothelial activation in pre-eclampsia is attributed to the release of unknown factors from a hypoperfused placenta. To further characterize these factors, we have used a serum-free placental villous explant culture model and investigated...

Authors: Nicola J Robinson, Mark Wareing, Nicola K Hudson, Richard T Blankley, Philip N Baker, John D...

Oncolytic adenoviral mutants with E1B19K gene deletions enhance gemcitabine-induced apoptosis in pancreatic carcinoma cells and anti-tumor efficacy in vivo.

PURPOSE: Pancreatic adenocarcinoma is a rapidly progressive malignancy that is highly resistant to current chemotherapeutic modalities and almost uniformly fatal. We show that a novel targeting strategy combining oncolytic adenoviral mutants with the...

Authors: Leitner S, Sweeney K, Oberg D, Davies D, Miranda E, Lemoine NR, Halldén G.

Dissection of host cell signal transduction during Acinetobacter baumannii-triggered inflammatory response.

Infected airway epithelial cells up-regulate the expression of chemokines, chiefly IL-8, and antimicrobial molecules including beta-defensins (BD). Acinetobacter baumannii is a cause of hospital-acquired pneumonia. We examined whether A. baumannii...

Authors: March C, Regueiro V, Llobet E, Moranta D, Morey P, Garmendia J, Bengoechea JA.

The role of IFN-gamma in regulation of IFN-gamma-inducible protein 10 (IP-10) expression in lung epithelial cell and peripheral blood mononuclear cell co-cultures.

BACKGROUND: Interferons play a critical role in regulating both the innate and adaptive immune responses. Previous reports have shown increased levels of IFN-gamma, IFN-gamma-inducing IL-12 and IFN-gamma-inducible chemokine IP-10 in patients with...

Authors: Torvinen M, Campwala H, Kilty I.

Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures.

To identify accessible and permissive human cell types for efficient derivation of induced pluripotent stem cells (iPSCs), we investigated epigenetic and gene expression signatures of multiple postnatal cell types such as fibroblasts and blood cells....

Authors: Chou BK, Mali P, Huang X, Ye Z, Dowey SN, Resar LM, Zou C, Zhang YA, Tong J, Cheng L.

SST Peer Reviewed

Inhibition of Glycogen Synthase Kinase-3 Increases NKG2D Ligand MICA Expression and Sensitivity to NK Cell-Mediated Cytotoxicity in Mutliple Myeloma Cells: Role of STAT3

Engagement of NKG2D and DNAX accessory molecule-1 (DNAM-1) receptors on lymphocytes plays an important role for anticancer response and represents an interesting therapeutic target for pharmacological modulation. In this study, we investigated the...

Authors: Fionda C, Malgarini G, Soriani A, Zingoni A, Cecere F, Iannitto M L, Ricciardi M R, Federico V,...

Congenital B cell lymphocytosis explained by novel germline CARD11 mutations.

Nuclear factor-?B (NF-?B) controls genes involved in normal lymphocyte functions, but constitutive NF-?B activation is often associated with B cell malignancy. Using high-throughput whole transcriptome sequencing, we investigated a unique family with...

Authors: Snow AL, Xiao W, Stinson JR, Lu W, Chaigne-Delalande B, Zheng L, Pittaluga S, Matthews HF, Schmitz...

SST Peer Reviewed

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PPAR? regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity

Arginine deficiency augments inflammatory mediator production by airway epithelial cells in vitro.

High-efficiency transfection and survival rates of embryonic and adult mouse neural stem cells achieved by electroporation.

Oxygen and the liberation of placental factors responsible for vascular compromise

Oncolytic adenoviral mutants with E1B19K gene deletions enhance gemcitabine-induced apoptosis in pancreatic carcinoma cells and anti-tumor efficacy in vivo.

Dissection of host cell signal transduction during Acinetobacter baumannii-triggered inflammatory response.

The role of IFN-gamma in regulation of IFN-gamma-inducible protein 10 (IP-10) expression in lung epithelial cell and peripheral blood mononuclear cell co-cultures.

Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures.

Inhibition of Glycogen Synthase Kinase-3 Increases NKG2D Ligand MICA Expression and Sensitivity to NK Cell-Mediated Cytotoxicity in Mutliple Myeloma Cells: Role of STAT3

Congenital B cell lymphocytosis explained by novel germline CARD11 mutations.