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Regulation of apoptotic effects by erythrocarpine E, a cytotoxic limonoid from Chisocheton erythrocarpus in HSC-4 human oral cancer cells

The aim of this study was to determine the cytotoxic and apoptotic effects of erythrocarpine E (CEB4), a limonoid extracted from Chisocheton erythrocarpus on human oral squamous cell carcinoma. Based on preliminary...

Authors: Nagoor NH, Shah Jehan Muttiah N, Lim CS, In LL, Mohamad K, Awang K.

Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium.

Egression of inflammatory cells from the lung interstitium into the airway lumen is critical for the resolution of inflammation, but the underlying mechanisms of this egression are unclear. Here, we use an in vitro system, in which human T cells...

Authors: Porter JC, Hall A.

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant.

Viral infections cause morbidity and mortality in allogeneic hematopoietic stem cell transplant (HSCT) recipients. We and others have successfully generated and infused T-cells specific for Epstein Barr virus (EBV), cytomegalovirus (CMV) and...

Authors: Gerdemann U, Vera JF, Rooney CM, Leen AM.

SST Peer Reviewed

Klebsiella pneumoniae increases the levels of Toll-like receptors 2 and 4 in human airway epithelial cells.

Airway epithelial cells act as the first barrier against pathogens. These cells recognize conserved structural motifs expressed by microbial pathogens via Toll-like receptors (TLRs) expressed on the surface. In contrast to the level of expression in...

Authors: Regueiro V, Moranta D, Campos MA, Margareto J, Garmendia J, Bengoechea JA.

Complete in vitro life cycle of Trypanosoma congolense: development of genetic tools.

BACKGROUND: Animal African trypanosomosis, a disease mainly caused by the protozoan parasite Trypanosoma congolense, is a major constraint to livestock productivity and has a significant impact in the developing countries of Africa. RNA interference...

Authors: Coustou V, Guegan F, Plazolles N, Baltz T.

SST Peer Reviewed

Concise review: putting a finger on stem cell biology: zinc finger nuclease-driven targeted genetic editing in human pluripotent stem cells.

Human pluripotent stem cells (hPSCs) encompassing human embryonic stem cells and human induced pluripotent stem cells (hiPSCs) have a wide appeal for numerous basic biology studies and for therapeutic applications because of their potential to give...

Authors: Collin J, Lako M.

SST Peer Reviewed

Generation of induced pluripotent stem cells from CD34+ cells across blood drawn from multiple donors with non-integrating episomal vectors

The methodology to create induced pluripotent stem cells (iPSCs) affords the opportunity to generate cells specific to the individual providing the host tissue. However, existing methods of reprogramming as well as the types of source tissue have...

Authors: Mack AA, Kroboth S, Rajesh D, Wang WB

SST Peer Reviewed

Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense.

Lactoperoxidase (LPO) is an enzyme with antimicrobial properties present in saliva, milk, tears, and airway secretions. Although the formation of microbicidal oxidants by LPO has been recognized for some time, the source of hydrogen peroxide (H2O2)...

Authors: Geiszt M, Witta J, Baffi J, Lekstrom K, Leto TL.

Improved protocol for efficient nonviral transfection of premature THP-1 macrophages.

INTRODUCTION: The human monocytic leukemia cell line THP-1 is a widely used model for investigating monocyte and macrophage biology. Successful transfection of THP-1 monocytes with subsequent phorbol 12-myristate 13-acetate (PMA)-induced...

Authors: Maess MB, Buers I, Robenek H, Lorkowski S.

SST Peer Reviewed

Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer.

LINE-1 and Alu elements are non-LTR retrotransposons, constituting together over 30% of the human genome and they are frequently hypomethylated in human tumors. A relationship between global hypomethylation and genomic instability has been shown,...

Authors: Daskalos A, Nikolaidis G, Xinarianos G, Savvari P, Cassidy A, Zakopoulou R, Kotsinas A, Gorgoulis V,...

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Regulation of apoptotic effects by erythrocarpine E, a cytotoxic limonoid from Chisocheton erythrocarpus in HSC-4 human oral cancer cells

Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium.

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant.

Klebsiella pneumoniae increases the levels of Toll-like receptors 2 and 4 in human airway epithelial cells.

Complete in vitro life cycle of Trypanosoma congolense: development of genetic tools.

Concise review: putting a finger on stem cell biology: zinc finger nuclease-driven targeted genetic editing in human pluripotent stem cells.

Generation of induced pluripotent stem cells from CD34+ cells across blood drawn from multiple donors with non-integrating episomal vectors

Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense.

Improved protocol for efficient nonviral transfection of premature THP-1 macrophages.

Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer.