Search Results

IL-22 suppresses IFN-gamma-mediated lung inflammation in asthmatic patients

BACKGROUND: IL-22 controls tissue homeostasis by both proinflammatory and anti-inflammatory effects. However, the anti-inflammatory mechanisms of IL-22 remain poorly investigated. OBJECTIVE: We sought to investigate the anti-inflammatory role for...

Authors: Pennino D, Bhavsar PK, Effner R, Avitabile S, Venn P, Quaranta M, Marzaioli V, Cifuentes L, Durham...

Enhancer of Zeste Homolog 2 Induces Pulmonary Artery Smooth Muscle Cell Proliferation

Introduction Pulmonary Arterial Hypertension (PAH) is a progressively devastating disease characterized by excessive proliferation of the Pulmonary Arterial Smooth Muscle Cells (PASMCs). Studies suggest that PAH and cancers share an...

Authors: Salman A. Aljubran, Ruan Cox, Jr, Prasanna Tamarapu Parthasarathy, Gurukumar Kollongod Ramanathan,...

SST Peer Reviewed

Influenza H5N1 and H1N1 virus replication and innate immune responses in bronchial epithelial cells are influenced by the state of differentiation

Influenza H5N1 virus continues to be enzootic in poultry and transmits zoonotically to humans. Although a swine-origin H1N1 virus has emerged to become pandemic, its virulence for humans remains modest in comparison to that seen in zoonotic H5N1...

Authors: Chan RW, Yuen KM, Yu WC, Ho CC, Nicholls JM, Peiris JS, Chan MC.

Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells.

We report here homologous recombination (HR)-mediated gene targeting of two different genes in human iPS cells (hiPSCs) and human ES cells (hESCs). HR-mediated correction of a chromosomally integrated mutant GFP reporter gene reaches efficiencies of...

Authors: Zou J, Maeder ML, Mali P, Pruett-Miller SM, Thibodeau-Beganny S, Chou BK, Chen G, Ye Z, Park IH,...

SST Peer Reviewed

Transcriptional restriction of human immunodeficiency virus type 1 gene expression in undifferentiated primary monocytes

Monocytes are critical precursors of dendritic cells and macrophages, which play an important role in the pathogenesis of human immunodeficiency virus type 1 (HIV-1). HIV-1 postentry infection is blocked in undifferentiated monocytes in vitro, while...

Authors: Dong C, Kwas C, Wu L

Hepcidin expression in human airway epithelial cells is regulated by interferon-gamma.

BACKGROUND: Hepcidin serves as a major regulator of systemic iron metabolism and immune function. Airway epithelial cells have an extensive interface with the environment, and so must be able to respond locally to the presence of particulates,...

Authors: Frazier MD, Mamo LB, Ghio AJ, Turi JL.

A FOXO-Pak1 transcriptional pathway controls neuronal polarity

Neuronal polarity is essential for normal brain development and function. However, cell-intrinsic mechanisms that govern the establishment of neuronal polarity remain to be identified. Here, we report that knockdown of endogenous FOXO proteins in...

Authors: de la Torre-Ubieta L, Gaudillière B, Yang Y, Ikeuchi Y, Yamada T, DiBacco S, Stegmüller J, Schüller...

Efficient oligonucleotide-mediated degradation of nuclear noncoding RNAs in mammalian cultured cells

Recent large-scale transcriptome analyses have revealed that large numbers of noncoding RNAs (ncRNAs) are transcribed from mammalian genomes. They include small nuclear RNAs (snRNAs), small nucleolar RNAs (snoRNAs), and longer ncRNAs, many of which...

Authors: Ideue T, Hino K, Kitao S, Yokoi T, Hirose T

SST Peer Reviewed

MARCKS and related chaperones bind to unconventional myosin V isoforms in airway epithelial cells

We have shown previously that myristoylated alanine-rich C kinase substrate (MARCKS) is a key regulatory molecule in the process of mucin secretion by airway epithelial cells, and that part of the secretory mechanism involves intracellular...

Authors: Lin KW, Fang S, Park J, Crews AL, Adler KB.

Negative regulators of insulin signaling revealed in a genome-wide functional screen

BACKGROUND: Type 2 diabetes develops due to a combination of insulin resistance and beta-cell failure and current therapeutics aim at both of these underlying causes. Several negative regulators of insulin signaling are known and are the subject of...

Authors: Huang SM, Hancock MK, Pitman JL, Orth AP, Gekakis N

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IL-22 suppresses IFN-gamma-mediated lung inflammation in asthmatic patients

Enhancer of Zeste Homolog 2 Induces Pulmonary Artery Smooth Muscle Cell Proliferation

Influenza H5N1 and H1N1 virus replication and innate immune responses in bronchial epithelial cells are influenced by the state of differentiation

Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells.

Transcriptional restriction of human immunodeficiency virus type 1 gene expression in undifferentiated primary monocytes

Hepcidin expression in human airway epithelial cells is regulated by interferon-gamma.

A FOXO-Pak1 transcriptional pathway controls neuronal polarity

Efficient oligonucleotide-mediated degradation of nuclear noncoding RNAs in mammalian cultured cells

MARCKS and related chaperones bind to unconventional myosin V isoforms in airway epithelial cells

Negative regulators of insulin signaling revealed in a genome-wide functional screen