Search Results

Regulation of prostate cancer cell invasion by modulation of extra- and intracellular redox balance.

Recent metabolic profiles of human prostate cancer tissues showed a significant increase in cysteine (Cys) and a significant decrease in reduced glutathione (GSH) during cancer progression from low- to high-grade Gleason scores. Cys is primarily...

Authors: Chaiswing L, Zhong W, Liang Y, Jones DP, Oberley TD.

Tobacco smoke induces polycomb-mediated repression of Dickkopf-1 in lung cancer cells

Limited information is available about epigenetic mechanisms by which cigarette smoke enhances the initiation and progression of lung cancer. To examine this issue, A549 and Calu-6 lung cancer cells were cultured in normal media with or without...

Authors: Hussain M, Rao M, Humphries AE, Hong JA, Liu F, Yang M, Caragacianu D, Schrump DS

Phospholipid scramblase 1 mediates type i interferon-induced protection against staphylococcal a-toxin

The opportunistic gram-positive pathogen Staphylococcus aureus is a leading cause of pneumonia and sepsis. Staphylococcal a-toxin, a prototypical pore-forming toxin, is a major virulence factor of S. aureus clinical isolates, and lung epithelial...

Authors: Lizak M, Yarovinsky TO

A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling.

Metabotropic glutamate receptor 5 (mGlu5) is a target for the treatment of central nervous system (CNS) disorders, such as schizophrenia and Alzheimer's disease. Furthermore, mGlu5 has been shown to play an important role in hippocampal synaptic...

Authors: Noetzel MJ, Gregory KJ, Vinson PN, Manka JT, Stauffer SR, Lindsley CW, Niswender CM, Xiang Z, Conn...

Distinct intracellular calcium responses of individual cultured human keratinocytes to air pressure changes.

BACKGROUND: We previously showed that application of hydraulic pressure to cultured human keratinocytes induced elevation of intracellular calcium concentration ([Ca(2+) ]i ), but the absolute value of the pressure could not be determined....

Authors: Ikeyama K, Nakatani M, Kumamoto J, Denda M

Staphylococcus aureus activates type I IFN signaling in mice and humans through the Xr repeated sequences of protein A

The activation of type I IFN signaling is a major component of host defense against viral infection, but it is not typically associated with immune responses to extracellular bacterial pathogens. Using mouse and human airway epithelial cells, we have...

Authors: Martin FJ, Gomez MI, Wetzel DM, Memmi G, O\'Seaghdha M, Soong G, Schindler C, Prince A

Pharmacologic effects of 2-methoxyestradiol on angiotensin type 1 receptor down-regulation in rat liver epithelial and aortic smooth muscle cells

BACKGROUND: Delayed onset of cardiovascular disease (CVD) in female patients is not well understood, but could be due in part to the protective effect of estrogen before menopause. Experimental studies have identified the angiotensin type 1 receptor...

Authors: Koganti S, Snyder R, Thekkumkara T

Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis.

We analyzed the gene expression profiles of clinical lung carcinomas using a cDNA microarray containing 27,648 genes or expressed sequence tags, and identified CDCA5 (cell division cycle associated 5) to be upregulated in the majority of lung...

Authors: Nguyen MH, Koinuma J, Ueda K, Ito T, Tsuchiya E, Nakamura Y, Daigo Y.

From understanding cellular function to novel drug discovery: the role of planar patch-clamp array chip technology

All excitable cell functions rely upon ion channels that are embedded in their plasma membrane. Perturbations of ion channel structure or function result in pathologies ranging from cardiac dysfunction to neurodegenerative disorders. Consequently, to...

Authors: Py C, Martina M, Diaz-Quijada GA, Luk CC, Martinez D, Denhoff MW, Charrier A, Comas T, Monette R,...

Technical considerations for reduced representation bisulfite sequencing with multiplexed libraries.

Reduced representation bisulfite sequencing (RRBS), which couples bisulfite conversion and next generation sequencing, is an innovative method that specifically enriches genomic regions with a high density of potential methylation sites and enables...

Authors: Chatterjee A, Rodger EJ, Stockwell PA, Weeks RJ, Morison IM.

Data Type

Category

Research Area

Platform

Topic

Species

Characteristic

Format

Origin