Search Results

Nicotinamide phosphoribosyl transferase (Nampt) is required for de novo lipogenesis in tumor cells.

Tumor cells have increased metabolic requirements to maintain rapid growth. In particular, a highly lipogenic phenotype is a hallmark of many tumor types, including prostate. Cancer cells also have increased turnover of nicotinamide adenine...

Authors: Bowlby SC, Thomas MJ, D\'Agostino RB Jr, Kridel SJ.

Coordinated regulation of polycomb group complexes through microRNAs in cancer.

Polycomb Repressive Complexes (PRC1 and PRC2)-mediated epigenetic regulation is critical for maintaining cellular homeostasis. Members of Polycomb Group (PcG) proteins including EZH2, a PRC2 component, are upregulated in various cancer types,...

Authors: Cao Q, Mani RS, Ateeq B, Dhanasekaran SM, Asangani IA, Prensner JR, Kim JH, Brenner JC, Jing X, Cao...

Local small airway epithelial injury induces global smooth muscle contraction and airway constriction

Small airway epithelial cells form a continuous sheet lining the conducting airways, which serves many functions including a physical barrier to protect the underlying tissue. In asthma, injury to epithelial cells can occur during...

Authors: Zhou J, Alvarez-Elizondo MB, Botvinick E, George SC

Multielectrode array analysis of cerebrospinal fluid in Alzheimer\'s disease versus mild cognitive impairment: a potential diagnostic and treatment biomarker

Pathological cerebrospinal fluid (CSF) alterations like changes in amyloid-ß1-42 and tau protein concentration are typical in Alzheimer's disease (AD). However, it remains unclear, if the composition of known or unknown pathological factors in native...

Authors: Görtz P, Siebler M, Ihl R, Henning U, Luckhaus C, Supprian T, Lange-Asschenfeldt C

Hsp90 inhibitors exhibit resistance-free antiviral activity against respiratory syncytial virus

Respiratory syncytial virus (RSV) is a major cause of respiratory illness in young children, leading to significant morbidity and mortality worldwide. Despite its medical importance, no vaccine or effective therapeutic interventions are currently...

Authors: Geller R, Andino R, Frydman J.

TLR2-induced calpain cleavage of epithelial junctional proteins facilitates leukocyte transmigration

Recruitment of polymorphonuclear leukocytes (PMNs) into the lungs in response to inhaled pathogens is initiated by epithelial signaling, the activation of toll-like receptors (TLRs), and the production of the chemokine interleukin-8. To reach the...

Authors: Chun J, Prince A.

Distinct redox profiles of selected human prostate carcinoma cell lines: implications for rational design of redox therapy.

The effects of several cancer chemotherapeutic drugs and radiation are mediated, at least in part, by oxidative stress. To better understand this process, we analyzed certain biochemical properties affecting reduction-oxidation (redox) balance in...

Authors: Chaiswing L, Zhong W, Oberley TD.

Polymer peel-off mask for high-resolution surface derivatization, neuron placement and guidance

We present a dry lift-off method using a chemically resistant spin-on plastic, polyimide, to pattern surfaces with high accuracy and resolution. Using well-known lithographic and reactive ion etching techniques, the spin-on polymer is patterned over...

Authors: Martinez D, Py C, Denhoff M, Monette R, Comas T, Krantis A, Mealing G

Thiazolidinediones induce proliferation of human bronchial epithelial cells through the GPR40 receptor

Thiazolidinediones (TZDs) are synthetic peroxisome proliferator-activated receptor-gamma (PPARgamma) ligands that are widely used in type II diabetes treatment. In addition to their ability to improve glucose homeostasis, TZDs possess...

Authors: Gras D, Chanez P, Urbach V, Vachier I, Godard P, Bonnans C

Anterograde trafficking of neurotrophin-3 in the adult olfactory system in vivo.

The olfactory system continuously incorporates new neurons into functional circuits throughout life. Axons from olfactory sensory neurons (OSNs) in the nasal cavity synapse on mitral, tufted and periglomerular (PG) cells in the main olfactory bulb,...

Authors: Liu H, Lu M, Guthrie KM

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