Search Results

Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptors.

Chronic immune activation in HIV-infected individuals leads to accumulation of exhausted tissue-like memory B cells. Exhausted lymphocytes display increased expression of multiple inhibitory receptors, which may contribute to the inefficiency of...

Authors: Kardava L, Moir S, Wang W, Ho J, Buckner CM, Posada JG, O'Shea MA, Roby G, Chen J, Sohn HW, Chun TW,...

SST Peer Reviewed

Dissection of host cell signal transduction during Acinetobacter baumannii-triggered inflammatory response.

Infected airway epithelial cells up-regulate the expression of chemokines, chiefly IL-8, and antimicrobial molecules including beta-defensins (BD). Acinetobacter baumannii is a cause of hospital-acquired pneumonia. We examined whether A. baumannii...

Authors: March C, Regueiro V, Llobet E, Moranta D, Morey P, Garmendia J, Bengoechea JA.

Smooth Muscle Cell–Specific Insulin-Like Growth Factor-1 Overexpression in Apoe / Mice Does Not Alter Atherosclerotic Plaque Burden but Increases Features of Plaque Stability

OBJECTIVE: Growth factors may play a permissive role in atherosclerosis initiation and progression, in part via their promotion of vascular smooth muscle cell (VSMC) accumulation in plaques. However, unstable human plaques often have a relative...

Authors: Shai SY, Sukhanov S, Higashi Y, Vaughn C, Kelly J, Delafontaine P

Transcriptome comparison of human neurons generated using induced pluripotent stem cells derived from dental pulp and skin fibroblasts.

Induced pluripotent stem cell (iPSC) technology is providing an opportunity to study neuropsychiatric disorders through the capacity to grow patient-specific neurons in vitro. Skin fibroblasts obtained by biopsy have been the most reliable source of...

Authors: Chen J, Lin M, Foxe JJ, Pedrosa E, Hrabovsky A, Carroll R, Zheng D, Lachman HM.

SST Peer Reviewed

The role of IFN-gamma in regulation of IFN-gamma-inducible protein 10 (IP-10) expression in lung epithelial cell and peripheral blood mononuclear cell co-cultures.

BACKGROUND: Interferons play a critical role in regulating both the innate and adaptive immune responses. Previous reports have shown increased levels of IFN-gamma, IFN-gamma-inducing IL-12 and IFN-gamma-inducible chemokine IP-10 in patients with...

Authors: Torvinen M, Campwala H, Kilty I.

A matrix micropatterning platform for cell localization and stem cell fate determination.

To study the role of cell-extracellular matrix (ECM) interactions, microscale approaches provide the potential to perform high throughput assessment of the effect of the ECM microenvironment on cellular function and phenotype. Using a microscale...

Authors: Huang NF, Patlolla B, Abilez O, Sharma H, Rajadas J, Beygui RE, Zarins CK, Cooke JP

Molecular mechanisms controlling CFTR gene expression in the airway.

The low levels of CFTR gene expression and paucity of CFTR protein in human airway epithelial cells are not easily reconciled with the pivotal role of the lung in cystic fibrosis pathology. Previous data suggested that the regulatory mechanisms...

Authors: Zhang Z, Ott CJ, Lewandowska MA, Leir SH, Harris A.

Effects of a novel cystine-based glutathione precursor on oxidative stress in vascular smooth muscle cells

Chronic kidney disease (CKD) is associated with accelerated atherosclerosis and cardiovascular disease, which is largely mediated by oxidative stress. We investigated the effect of three glutathione (GSH) precursors: N-acetyl-cysteine (NAC), cystine...

Authors: Sinha-Hikim I, Shen R, Paul Lee WN, Crum A, Vaziri ND, Norris KC.

Cardiotoxicity of the anticancer therapeutic agent bortezomib

Recent case reports provided alarming signals that treatment with bortezomib might be associated with cardiac events. In all reported cases, patients experiencing cardiac problems were previously or concomitantly treated with other chemotherapeutics...

Authors: Nowis D, Maczewski M, Mackiewicz U, Kujawa M, Ratajska A, Wieckowski MR, Wilczynski GM, Malinowska...

TRAIL promotes caspase-dependent pro-inflammatory responses via PKCd activation by vascular smooth muscle cells

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is best known for its selective cytotoxicity against transformed tumor cells. Most non-transformed primary cells and several cancer cell lines are not only resistant to death...

Authors: Song S, Choi K, Ryu SW, Kang SW, Choi C

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