Search Results

Specificity of olfactory receptor interactions with other G protein-coupled receptors

Studies on olfactory receptor (OR) pharmacology have been hindered by the poor plasma membrane localization of most ORs in heterologous cells. We previously reported that association with the beta(2)-adrenergic receptor (beta(2)-AR) facilitates...

Authors: Bush CF, Jones SV, Lyle AN, Minneman KP, Ressler KJ, Hall RA

The loss of immunodominant epitopes affects interferon-gamma production and lytic activity of the human influenza virus-specific cytotoxic T lymphocyte response in vitro

In the present study, we examined the effect of the loss of the human leucocyte antigen (HLA)-B*3501-restricted nucleoprotein (NP)(418-426) epitope on interferon (IFN)-gamma-production and lytic activity of the human cytotoxic T lymphocyte (CTL)...

Authors: Berkhoff EG, Geelhoed-Mieras MM, Verschuren EJ, van Baalen CA, Gruters RA, Fouchier RA, Osterhaus...

Modulation of estrogen receptor alpha protein level and survival function by DBC-1

Acquired resistance to endocrine therapy represents a major clinical obstacle to the successful management of estrogen-dependent breast cancers expressing estrogen receptor alpha (ERalpha). Because a switch from ligand-dependent to ligand-independent...

Authors: Trauernicht AM, Kim SJ, Kim NH, Boyer TG

Retinoic Acid regulates CD1d gene expression at the transcriptional level in human and rodent monocytic cells

CD1d belongs to a group of nonclassical antigen-presenting molecules that present glycolipid antigens and thereby activate natural killer T (NKT) cells, a subset of bifunctional T cells. Little is known so far regarding the expression and physiologic...

Authors: Chen Q, Ross AC

Introns regulate the rate of unstable mRNA decay

The expression of neutrophil-specific chemokines is known to be regulated via adenine-uridine-rich sequence elements in the 3'-untranslated regions of their mRNAs that confer a high degree of mRNA instability. Although the presence of intron...

Authors: Zhao C, Hamilton T

Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells

Transforming growth factor-beta1 (TGF-beta1) plays a pivotal role in increasing airway smooth muscle mass in severe asthma by inducing proliferation and hypertrophy of human airway smooth muscle. The mechanism(s) for these effects of TGF-beta1 have...

Authors: Sturrock A, Huecksteadt TP, Norman K, Sanders KA, Murphy TM, Chitano P, Wilson K, Hoidal JR, Kennedy...

SST Peer Reviewed

Live cell imaging of phagosome maturation in Staphylococcus aureus infected human endothelial cells: small colony variants are able to survive in lysosomes

Small colony variants (SCVs) of Staphylococcus aureus have been proposed to persist within vascular endothelium, thereby sustaining chronic infections. To identify the intracellular SCV location we infected primary human endothelial cells with...

Authors: Schroder A, Kland R, Peschel A, von Eiff C, Aepfelbacher M

Vasoactive intestinal peptide transactivates the androgen receptor through a PKA-dependent extracellular signal-regulated kinase pathway in prostate cancer LNCaP cells

Acquisition of androgen independence by prostate cancer is the key problem of prostate cancer progression. Vasoactive intestinal peptide (VIP), a neuropeptide, may act as a survival factor for prostate cancer cells under androgen deprivation....

Authors: Xie Y, Wolff DW, Lin MF, Tu Y

SST Peer Reviewed

Novel RUNX1 isoforms determine the fate of acute myeloid leukemia cells by controlling CD56 expression

CD56(high) acute myeloid leukemias (AMLs) have a poor prognosis but it has been unclear how CD56 expression is controlled and how it relates to clinical aggressiveness. We show here that CD56 expression on AML cells correlates with an abnormal...

Authors: Gattenloehner S, Chuvpilo S, Langebrake C, Reinhardt D, Muller-Hermelink HK, Serfling E, Vincent A,...

SST Peer Reviewed

Up-Regulation of Gene Related to Anergy in Lymphocytes Is Associated with Notch-Mediated Human T Cell Suppression

A growing body of literature indicates that the Notch pathway can influence the activation and differentiation of peripheral murine T cells, though comparatively little is known about the effects of Notch signaling in human T cells. In the present...

Authors: Kostianovsky AM, Maier LM, Baecher-Allan C, Anderson AC, Anderson DE

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Specificity of olfactory receptor interactions with other G protein-coupled receptors

The loss of immunodominant epitopes affects interferon-gamma production and lytic activity of the human influenza virus-specific cytotoxic T lymphocyte response in vitro

Modulation of estrogen receptor alpha protein level and survival function by DBC-1

Retinoic Acid regulates CD1d gene expression at the transcriptional level in human and rodent monocytic cells

Introns regulate the rate of unstable mRNA decay

Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells

Live cell imaging of phagosome maturation in Staphylococcus aureus infected human endothelial cells: small colony variants are able to survive in lysosomes

Vasoactive intestinal peptide transactivates the androgen receptor through a PKA-dependent extracellular signal-regulated kinase pathway in prostate cancer LNCaP cells

Novel RUNX1 isoforms determine the fate of acute myeloid leukemia cells by controlling CD56 expression

Up-Regulation of Gene Related to Anergy in Lymphocytes Is Associated with Notch-Mediated Human T Cell Suppression