Search Results

Stimulation of c-Myc transcriptional activity by vIRF-3 of Kaposi's sarcoma-associated herpesvirus

Kaposi sarcoma-associated herpesvirus is associated with two lymphoproliferative disorders, primary effusion lymphoma (PEL) and Castleman disease. In PEL, Kaposi sarcoma-associated herpesvirus is present in a latent form expressing only few viral...

Authors: Lubyova B, Kellum MJ, Frisancho JA, Pitha PM

A mouse model for nonsense mutation bypass therapy shows a dramatic multiday response to geneticin

Aminoglycosides can bypass nonsense mutations and are the prototypic agents for translational bypass therapy (TBT). Initial results demonstrate the need for more potent drugs and an in vivo model system for quantitative assessment of TBT. Herein, we...

Authors: Yang C, Feng J, Song W, Wang J, Tsai B, Zhang Y, Scaringe WA, Hill KA, Margaritis P, High KA, Sommer...

The novel adaptor protein Swiprosin-1 enhances BCR signals and contributes to BCR-induced apoptosis

B-cell receptor (BCR) signals are essential for B-cell differentiation, homeostasis and negative selection, which are regulated by the strength and quality of BCR signals. Recently, we identified a new adaptor protein, Swiprosin-1, in lipid rafts of...

Authors: Avramidou A, Kroczek C, Lang C, Schuh W, Jäck HM, Mielenz D

Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury

Loss of mitochondrial membrane integrity and release of apoptogenic factors are a key step in the signaling cascade leading to neuronal cell death in various neurological disorders, including ischemic injury. Emerging evidence has suggested that the...

Authors: Cao G, Xing J, Xiao X, Liou AK, Gao Y, Yin XM, Clark RS, Graham SH, Chen J

Microbial Products Stimulate Human Toll-like Receptor 2 Expression through Histone Modification Surrounding a Proximal NF-B-binding Site

Previous studies have yielded conflicting results regarding the ability of microbial products to activate TLR2 gene expression in human monocytes. In this study, we found that TLR2 mRNA was rapidly up-regulated in human monocytes treated with TLR2...

Authors: Johnson CM, Tapping RI

Kalirin/Trio rho Guanine nucleotide exchange factors regulate a novel step in secretory granule maturation

The molecular mechanisms involved in the maturation of secretory granules, organelles that store hormones and neuropeptides, are poorly understood. As granule content proteins are processed, the composition of granule membranes changes, yielding...

Authors: Ferraro F, Ma XM, Sobota JA, Eipper BA, Mains RE

Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1

gamma-Secretase is involved in the production of amyloid beta-peptide, which is the principal component of amyloid plaques in the brains of patients with Alzheimer disease. gamma-Secretase is a complex composed of presenilin (PS), nicastrin, anterior...

Authors: Kaether C, Scheuermann J, Fassler M, Zilow S, Shirotani K, Valkova C, Novak B, Kacmar S, Steiner H,...

Interaction between Transmembrane TNF and TNFR1/2 Mediates the Activation of Monocytes by Contact with T Cells

Monocytes and monocytic cells produce proinflammatory cytokines upon direct cell contact with activated T cells. In the autoimmune disease rheumatoid arthritis, the pivotal role of TNF-alpha implies that the interaction between transmembrane...

Authors: Rossol M, Meusch U, Pierer M, Kaltenhäuser S, Häntzschel H, Hauschildt S, Wagner U

SST Peer Reviewed

The C terminus of the synovial sarcoma-associated SSX proteins interacts with the LIM homeobox protein LHX4

As a result of the synovial sarcoma-associated t(X;18) translocation, the SS18 gene on chromosome 18 is fused to either one of the three closely related SSX genes on the X chromosome. The SS18 protein is thought to act as a transcriptional...

Authors: de Bruijn DR, van Dijk AH, Willemse MP, van Kessel AG

A biochemical signature for rapid recall of memory CD4 T cells

Mechanisms for the rapid recall response mediated by memory T cells remain unknown. In this study, we present a novel, multiparameter analysis of TCR-coupled signaling and function in resting and activated naive and memory CD4 T cells, revealing a...

Authors: Chandok MR, Okoye FI, Ndejembi MP, Farber DL

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