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Identification of gene signatures and molecular markers for human lung cancer prognosis using an in vitro lung carcinogenesis system

Lung cancer continues to be a major deadly malignancy. The mortality of this disease could be reduced by improving the ability to predict cancer patients' survival. We hypothesized that genes differentially expressed among cells constituting an in...

Authors: Kadara H, Lacroix L, Behrens C, Solis L, Gu X, Lee JJ, Tahara E, Lotan D, Hong WK, Wistuba II, Lotan...

Enhancer of Zeste Homolog 2 Induces Pulmonary Artery Smooth Muscle Cell Proliferation

Introduction Pulmonary Arterial Hypertension (PAH) is a progressively devastating disease characterized by excessive proliferation of the Pulmonary Arterial Smooth Muscle Cells (PASMCs). Studies suggest that PAH and cancers share an...

Authors: Salman A. Aljubran, Ruan Cox, Jr, Prasanna Tamarapu Parthasarathy, Gurukumar Kollongod Ramanathan,...

SST Peer Reviewed

Cigarette smoke extract reduces VEGF in primary human airway epithelial cells

Reduced vascular endothelial growth factor (VEGF) has been reported in bronchoalveolar lavage fluid and lungs of severe emphysema patients. Airway epithelial cells (AEC) are exposed to various environmental insults like cigarette smoke and bacterial...

Authors: Thaikoottathil JV, Martin RJ, Zdunek J, Weinberger A, Rino JG, Chu HW

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant.

Viral infections cause morbidity and mortality in allogeneic hematopoietic stem cell transplant (HSCT) recipients. We and others have successfully generated and infused T-cells specific for Epstein Barr virus (EBV), cytomegalovirus (CMV) and...

Authors: Gerdemann U, Vera JF, Rooney CM, Leen AM.

SST Peer Reviewed

Lung epithelial injury by B. anthracis lethal toxin is caused by MKK-dependent loss of cytoskeletal integrity

Bacillus anthracis lethal toxin (LT) is a key virulence factor of anthrax and contributes significantly to the in vivo pathology. The enzymatically active component is a Zn(2+)-dependent metalloprotease that cleaves most isoforms of mitogen-activated...

Authors: Lehmann M, Noack D, Wood M, Perego M, Knaus UG.

Concise review: putting a finger on stem cell biology: zinc finger nuclease-driven targeted genetic editing in human pluripotent stem cells.

Human pluripotent stem cells (hPSCs) encompassing human embryonic stem cells and human induced pluripotent stem cells (hiPSCs) have a wide appeal for numerous basic biology studies and for therapeutic applications because of their potential to give...

Authors: Collin J, Lako M.

SST Peer Reviewed

IL-22 suppresses IFN-gamma-mediated lung inflammation in asthmatic patients

BACKGROUND: IL-22 controls tissue homeostasis by both proinflammatory and anti-inflammatory effects. However, the anti-inflammatory mechanisms of IL-22 remain poorly investigated. OBJECTIVE: We sought to investigate the anti-inflammatory role for...

Authors: Pennino D, Bhavsar PK, Effner R, Avitabile S, Venn P, Quaranta M, Marzaioli V, Cifuentes L, Durham...

Improved protocol for efficient nonviral transfection of premature THP-1 macrophages.

INTRODUCTION: The human monocytic leukemia cell line THP-1 is a widely used model for investigating monocyte and macrophage biology. Successful transfection of THP-1 monocytes with subsequent phorbol 12-myristate 13-acetate (PMA)-induced...

Authors: Maess MB, Buers I, Robenek H, Lorkowski S.

SST Peer Reviewed

Influenza H5N1 and H1N1 virus replication and innate immune responses in bronchial epithelial cells are influenced by the state of differentiation

Influenza H5N1 virus continues to be enzootic in poultry and transmits zoonotically to humans. Although a swine-origin H1N1 virus has emerged to become pandemic, its virulence for humans remains modest in comparison to that seen in zoonotic H5N1...

Authors: Chan RW, Yuen KM, Yu WC, Ho CC, Nicholls JM, Peiris JS, Chan MC.

Oxygen and the liberation of placental factors responsible for vascular compromise

Maternal endothelial activation in pre-eclampsia is attributed to the release of unknown factors from a hypoperfused placenta. To further characterize these factors, we have used a serum-free placental villous explant culture model and investigated...

Authors: Nicola J Robinson, Mark Wareing, Nicola K Hudson, Richard T Blankley, Philip N Baker, John D...

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Identification of gene signatures and molecular markers for human lung cancer prognosis using an in vitro lung carcinogenesis system

Enhancer of Zeste Homolog 2 Induces Pulmonary Artery Smooth Muscle Cell Proliferation

Cigarette smoke extract reduces VEGF in primary human airway epithelial cells

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant.

Lung epithelial injury by B. anthracis lethal toxin is caused by MKK-dependent loss of cytoskeletal integrity

Concise review: putting a finger on stem cell biology: zinc finger nuclease-driven targeted genetic editing in human pluripotent stem cells.

IL-22 suppresses IFN-gamma-mediated lung inflammation in asthmatic patients

Improved protocol for efficient nonviral transfection of premature THP-1 macrophages.

Influenza H5N1 and H1N1 virus replication and innate immune responses in bronchial epithelial cells are influenced by the state of differentiation

Oxygen and the liberation of placental factors responsible for vascular compromise