Search Results

Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans

Keratan sulfate glycosaminoglycans are among the most abundant carbohydrate components of the cornea and are suggested to play an important role in maintaining corneal extracellular matrix structure. Keratan sulfate carbohydrate chains consist of...

Authors: Kitayama K, Hayashida Y, Nishida K, Akama TO

Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth

Neurotrophins, such as NGF and BDNF, induce sustained activation of Rap1 small G protein and ERK, which are essential for neurite outgrowth. We show involvement of a GDP/GTP exchange factor (GEF) for Rap1, PDZ-GEF1, in these processes. PDZ-GEF1 is...

Authors: Hisata S, Sakisaka T, Baba T, Yamada T, Aoki K, Matsuda M, Takai Y

The oncoprotein NPM-ALK of anaplastic large cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling

Anaplastic large cell lymphomas (ALCL) are highly proliferating tumors that commonly express the AP-1 transcription factor JunB. ALK fusions occur in about 50% of ALCL, and among these 80% have the t(2;5) translocation with NPM-ALK expression. We...

Authors: Staber PB, Vesely P, Haq N, Ott RG, Funato K, Bambach I, Fuchs C, Schauer S, Linkesch W, Hrzenjak A,...

Epstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survival

Many cells latently infected with Epstein-Barr virus (EBV), including certain virus-associated tumors, express latent membrane protein 2A (LMP2A) suggesting an important role for this protein in viral latency and oncogenesis. LMP2A mimics B-cell...

Authors: Mancao C, Hammerschmidt W

JAK2 tyrosine kinase phosphorylates PAK1 and regulates PAK1 activity and functions

The serine-threonine kinase PAK1 is activated by small GTPase-dependent and -independent mechanisms and promotes cell survival. However, the role of tyrosyl phosphorylation in the regulation of PAK1 function is poorly understood. In this study, we...

Authors: Rider L, Shatrova A, Feener EP, Webb L, Diakonova M

Annexin 1 cleavage in activated neutrophils: A pivotal role for proteinase 3

Annexin 1 is an anti-inflammatory protein that plays a key role in innate immunity by modulating the activation of several types of cells including neutrophils. Here we have developed a cleavage assay, using tagged annexin 1, and observed marked...

Authors: Vong L, D'Acquisto F, Pederzoli-Ribeil M, Lavagno L, Flower RJ, Witko-Sarsat V, Perretti M

Genetic and pharmacological inhibition of Rho-associated kinase II enhances adipogenesis

Rho-associated kinase (ROCK) regulates reorganization of actin cytoskeleton. During adipogenesis, the structure of filamentous actin is converted from long stress fibers to cortical actin, suggesting that the ROCK is involved in adipogenesis. Two...

Authors: Noguchi M, Hosoda K, Fujikura J, Fujimoto M, Iwakura H, Tomita T, Ishii T, Arai N, Hirata M, Ebihara...

Mechanical Stretch Inhibits Oxidized Low Density Lipoprotein-induced Apoptosis in Vascular Smooth Muscle Cells by Up-regulating Integrin alphaVbeta3 and Stablization of PINCH-1

To determine the mechanisms involved in regulating the balance between apoptosis and survival in vascular smooth muscle cells (VSMC), we studied anti-apoptotic stimuli that can counteract pro-apoptotic events in the process of early atherosclerotic...

Authors: Cheng J, Zhang J, Merched A, Zhang L, Zhang P, Truong L, Boriek AM, Du J

Drp1 mediates caspase-independent type III cell death in normal and leukemic cells

Ligation of CD47 triggers caspase-independent programmed cell death (PCD) in normal and leukemic cells. Here, we characterize the morphological and biochemical features of this type of death and show that it displays the hallmarks of type III PCD. A...

Authors: Bras M, Yuste VJ, Roué G, Barbier S, Sancho P, Virely C, Rubio M, Baudet S, Esquerda JE, Merle-Béral...

EP2 receptor mediates PGE2-induced cystogenesis of human renal epithelial cells

Autosomal-dominant polycystic kidney disease (ADPKD) is characterized by formation of cysts from tubular epithelial cells. Previous studies indicate that secretion of prostaglandin E(2) (PGE(2)) into cyst fluid and production of cAMP underlie cyst...

Authors: Elberg G, Elberg D, Lewis TV, Guruswamy S, Chen L, Logan CJ, Chan MD, Turman MA

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