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Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences

Polycomb group proteins are transcriptional repressors recruited to many developmental control genes. The specificity of polycomb group protein targeting is incompletely understood. Subunits of polycomb repressive complexes (PRC) are encoded by...

Authors: Vincenz C, Kerppola TK

The control of Ca2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension

Many excitable cells express L-type Ca(2+) channels (LTCCs), which participate in physiological and pathophysiological processes ranging from memory, secretion, and contraction to epilepsy, heart failure, and hypertension. Clusters of LTCCs can...

Authors: Nieves-Cintron M, Amberg GC, Navedo MF, Molkentin JD, Santana LF

Evaluation of three commercial kits for mycoplasma NAT assays: selection and quality improvement.

Authors: Dorange F, Le Goff F, Dumey N

SST Peer Reviewed

A novel phosphatase cascade regulates differentiation in Trypanosoma brucei via a glycosomal signaling pathway.

In the mammalian bloodstream, the sleeping sickness parasite Trypanosoma brucei is held poised for transmission by the activity of a tyrosine phosphatase, TbPTP1. This prevents differentiation of the transmissible "stumpy forms" until entry into the...

Authors: Szöor B, Ruberto I, Burchmore R, Matthews KR.

Cross comparison of rapid mycoplasma detection platforms

The use of animal and plant derived raw materials in mammalian cell culture processes may provide a possible route of entry for adventitious contaminants such as mycoplasma. Mycoplasma contaminations of cell culture represent a serious challenge to...

Authors: Lawrence B, Bashiri H, Dehghani H

SST Peer Reviewed

Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/PI3-kinase/AKT-2 pathway

Heme oxygenase 1 (HO-1) is a representative mediator of antioxidants and cytoprotectants against various stress stimuli including oxidants in vascular cells. Intensive insulin treatment can delay the onset and progression of diabetic retinopathy and...

Authors: Geraldes P, Yagi K, Ohshiro Y, He Z, Maeno Y, Yamamoto-Hiraoka J, Rask-Madsen C, Chung SW, Perrella...

Site-specific DNA double-strand breaks greatly increase stable transformation efficiency in Trypanosoma brucei.

Genetic manipulation in African trypanosomes typically relies upon electroporation with chromosomal integration of DNA constructs by homologous recombination. Relatively little is known about chromosomal recombination and repair in these organisms...

Authors: Glover L, Horn D.

SST Peer Reviewed

Comparative transfection of DNA into primary and transformed mammalian cells from different lineages

BACKGROUND: The delivery of DNA into human cells has been the basis of advances in the understanding of gene function and the development of genetic therapies. Numerous chemical and physical approaches have been used to deliver the DNA, but their...

Authors: Maurisse R, De Semir D, Emamekhoo H, Bedayat B, Abdolmohammadi A, Parsi H, Gruenert DC

SST Peer Reviewed

Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptors.

Chronic immune activation in HIV-infected individuals leads to accumulation of exhausted tissue-like memory B cells. Exhausted lymphocytes display increased expression of multiple inhibitory receptors, which may contribute to the inefficiency of...

Authors: Kardava L, Moir S, Wang W, Ho J, Buckner CM, Posada JG, O'Shea MA, Roby G, Chen J, Sohn HW, Chun TW,...

SST Peer Reviewed

Transcriptome comparison of human neurons generated using induced pluripotent stem cells derived from dental pulp and skin fibroblasts.

Induced pluripotent stem cell (iPSC) technology is providing an opportunity to study neuropsychiatric disorders through the capacity to grow patient-specific neurons in vitro. Skin fibroblasts obtained by biopsy have been the most reliable source of...

Authors: Chen J, Lin M, Foxe JJ, Pedrosa E, Hrabovsky A, Carroll R, Zheng D, Lachman HM.

SST Peer Reviewed

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Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences

The control of Ca2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension

Evaluation of three commercial kits for mycoplasma NAT assays: selection and quality improvement.

A novel phosphatase cascade regulates differentiation in Trypanosoma brucei via a glycosomal signaling pathway.

Cross comparison of rapid mycoplasma detection platforms

Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/PI3-kinase/AKT-2 pathway

Site-specific DNA double-strand breaks greatly increase stable transformation efficiency in Trypanosoma brucei.

Comparative transfection of DNA into primary and transformed mammalian cells from different lineages

Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptors.

Transcriptome comparison of human neurons generated using induced pluripotent stem cells derived from dental pulp and skin fibroblasts.