Search Results

Involvement of integrin-induced activation of protein kinase C in the formation of adherens junctions

In epithelial cells, tight junctions (TJs) and adherens junctions (AJs) form junctional complexes. At AJs, cadherins and nectins are the major cell-cell adhesion molecules. Nectins first form cell-cell adhesions and then recruit cadherins to the...

Authors: Ozaki M, Ogita H, Takai Y

Epigenetic regulation of tumor necrosis factor alpha

Tumor necrosis factor alpha (TNF-alpha) is a potent cytokine which regulates inflammation via the induction of adhesion molecules and chemokine expression. Its expression is known to be regulated in a complex manner with transcription, message...

Authors: Sullivan KE, Reddy AB, Dietzmann K, Suriano AR, Kocieda VP, Stewart M, Bhatia M

The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2

Ataxin-1 is a neurodegenerative disorder protein whose mutant form causes spinocerebellar ataxia type-1 (SCA1). Evidence suggests that ataxin-1 may function as a transcription repressor. However, neither the importance of this putative...

Authors: Bolger TA, Zhao X, Cohen TJ, Tsai CC, Yao TP

BMP4 Induces HO-1 via a Smad-Independent, p38MAPK-Dependent Pathway in Pulmonary Artery Myocytes

Bone morphogenetic proteins (BMPs) are multifunctional cytokines, which play a key role in vascular development and remodeling. Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme catabolism, has been shown to be protective against vascular and...

Authors: Yang X, Lee PJ, Long L, Trembath RC, Morrell NW

Dishevelled promotes axon differentiation by regulating atypical protein kinase C

The atypical protein kinase C (aPKC) in complex with PAR3 and PAR6 is required for axon-dendrite differentiation, but the upstream factors responsible for regulating its activity are largely unknown. Here, we report that in cultured hippocampal...

Authors: Zhang X, Zhu J, Yang GY, Wang QJ, Qian L, Chen YM, Chen F, Tao Y, Hu HS, Wang T, Luo ZG

Epigenetic silencing of TNFalpha during endotoxin tolerance

Sustained silencing of potentially autotoxic acute proinflammatory genes like tumor necrosis factor alpha (TNFalpha) occurs in circulating leukocytes following the early phase of severe systemic inflammation. Aspects of this gene reprogramming...

Authors: El Gazzar M, Yoza BK, Hu JY, Cousart SL, McCall CE

Thiazolidinediones Modulate the Expression of -Catenin and Other Cell-Cycle Regulatory Proteins by Targeting the F-Box Proteins of SCF E3 Ubiquitin Ligase Independently of PPAR

Thiazolidinediones Modulate the Expression of beta-Catenin and Other Cell-Cycle Regulatory Proteins by Targeting the F-Box ProtConsidering the role of aberrant beta-catenin signaling in tumorigenesis, we investigated the mechanism by which the...

Authors: Wei S, Lin LF, Yang CC, Wang YC, Chang GD, Chen H, Chen CS

Syk-dependent Actin Dynamics Regulate Endocytic Trafficking and Processing of Antigens Internalized through the B Cell Receptor

Antigen binding to the B-cell receptor (BCR) induces multiple signaling cascades that ultimately lead to B lymphocyte activation. In addition, the BCR regulates the key trafficking events that allow the antigen to reach endocytic compartments devoted...

Authors: Le Roux D, Lankar D, Yuseff MI, Vascotto F, Yokozeki T, Faure-André G, Mougneau E, Glaichenhaus N,...

Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation

Spinocerebellar ataxia type 7 (SCA7) is a polyglutamine (polyQ) disorder characterized by specific degeneration of cerebellar, brainstem and retinal neurons. Although they share little sequence homology, proteins implicated in CAG trinucleotide...

Authors: Young JE, Gouw L, Propp S, Sopher BL, Taylor J, Lin A, Hermel E, Logvinova A, Chen SF, Chen S,...

Cytotoxic phospholipid oxidation products: Cell death from mitochondrial damage and the intrinsic caspase cascade

Phospholipid oxidation products accumulate in the necrotic core of atherosclerotic lesions, in apoptotic cells, and circulate in oxidized LDL. Phospholipid oxidation generates toxic products, but little is known about which specific products are...

Authors: Chen R, Yang L, McIntyre TM

Data Type

Category

Research Area

Platform

Topic

Species

Characteristic

Format

Origin