Search Results

The autophagic inducer smARF interacts with and is stabilized by the mitochondrial p32 protein

The alternative reading frame (ARF) mRNA encodes two pro-death proteins, the nucleolar p19ARF and a shorter mitochondrial isoform, named smARF (hsmARF in human). While p19ARF can inhibit cell growth by causing cell cycle arrest or type I apoptotic...

Authors: Reef S, Shifman O, Oren M, Kimchi A

Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, P38alpha , through MKK3/6-independent and -dependent mechanisms

Previously, we identified five active phosphatidylinositol ether lipid analogues (PIAs) that target the pleckstrin homology domain of Akt and selectively induce apoptosis in cancer cells with high levels of Akt activity. To examine specificity, PIAs...

Authors: Gills JJ, Castillo SS, Zhang C, Petukhov PA, Memmott RM, Hollingshead M, Warfel N, Han J, Kozikowski...

Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype

Thymic-derived natural T-regulatory cells (nTregs) are important for the induction of self-tolerance and the control of autoimmunity. Murine CD4+CD25(-)Foxp3(-) cells can be induced to express Foxp3 after T-cell receptor (TCR) activation in the...

Authors: Tran DQ, Ramsey H, Shevach EM

Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells

The mechanisms underlying G-CSF-induced mobilization of granulocytic lineage cells from the bone marrow to the peripheral blood remain elusive. We provide evidence that the transcriptional repressor Gfi-1 is involved in G-CSF-induced mobilization of...

Authors: De La Luz Sierra M, Gasperini P, McCormick PJ, Zhu J, Tosato G

Estrogen increases smooth muscle expression of alpha2C-adrenoceptors and cold-induced constriction of cutaneous arteries

Raynaud's phenomenon, which is characterized by intense cold-induced constriction of cutaneous arteries, is more common in women compared with men. Cold-induced constriction is mediated in part by enhanced activity of alpha(2C)-adrenoceptors...

Authors: Eid AH, Maiti K, Mitra S, Chotani MA, Flavahan S, Bailey SR, Thompson-Torgerson CS, Flavahan NA

Sumoylation in axons triggers retrograde transport of the RNA-binding protein La

A surprisingly large population of mRNAs has been shown to localize to sensory axons, but few RNA-binding proteins have been detected in these axons. These axonal mRNAs include several potential binding targets for the La RNA chaperone protein. La is...

Authors: van Niekerk EA, Willis DE, Chang JH, Reumann K, Heise T, Twiss JL

Human cytomegalovirus gene expression is silenced by the Daxx-mediated intrinsic immune defense when model latent infections are established in vitro

In addition to productive lytic infections, herpesviruses such as human cytomegalovirus (HCMV) establish a reservoir of latently infected cells that permit lifelong colonization of the host. When latency is established, the viral immediate-early (IE)...

Authors: Saffert RT, Kalejta RF

Autophagy in Niemann-Pick C disease is dependent upon Beclin-1 and responsive to lipid trafficking defects

Niemann-Pick C (NPC) disease is an autosomal recessive lipid storage disorder characterized by a disruption of sphingolipid and cholesterol trafficking that produces cognitive impairment, ataxia and death, often in childhood. Most cases are caused by...

Authors: Pacheco CD, Kunkel R, Lieberman AP

CD98hc (SLC3a2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling

In mammals, beta1 integrin adhesion receptors generate signals that mediate cell spreading, migration, proliferation, and survival. CD98, a heterodimeric transmembrane protein, physically associates with certain integrin beta subunit cytoplasmic...

Authors: Prager GW, Feral CC, Kim C, Han J, Ginsberg MH

In vitro models of TGF-beta-induced fibrosis suitable for high-throughput screening of antifibrotic agents

Progressive fibrosis is a cause of progressive organ dysfunction. Lack of quantitative in vitro models of fibrosis accounts, at least partially, for the slow progress in developing effective anti-fibrotic drugs. Here we report two complementary in...

Authors: Xu Q, Norman JT, Shrivastav S, Lucio-Cazana J, Kopp JB

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