Search Results

Lipopolysaccharide-induced expression of matrix metalloproteinases in human monocytes is suppressed by IFN-gamma via superinduction of ATF-3 and suppression of AP-1

Lipopolysaccharide-induced expression of matrix metalloproteinases in human monocytes is suppressed by IFN-gamma via superinduction of ATF-3 and suppression of AP-1. Ho HH, Antoniv TT, Ji JD, Ivashkiv LB. Arthritis and Tissue Degeneration...

Authors: Ho HH, Antoniv TT, Ji JD, Ivashkiv LB

Dual-specificity A-kinase anchoring proteins (AKAPs) contain an additional binding region that enhances targeting of PKA type I

A-kinase anchoring proteins (AKAPs) target Protein Kinase A (PKA) to a variety of subcellular locations. Conventional AKAPs contain a 14-18 amino acid sequence that forms an amphipathic helix that binds with high affinity to the regulatory (R)...

Authors: Jarnaess E, Ruppelt A, Stokka AJ, Lygren B, Scott JD, Tasken K

Promoter analysis reveals critical roles for SMAD-3 and ATF-2 in expression of IL-23 p19 in macrophages

IL-23 p19/p40, produced by macrophages and dendritic cells, is critical for development of Th17 in several autoimmune diseases. In this study, bone marrow-derived (BMM) and splenic macrophages (SPM) from SJL/J mice, susceptible to autoimmune...

Authors: Al-Salleeh F, Petro TM

NFATc1 regulates PD-1 expression upon T cell activation

PD-1 is a transmembrane protein involved in the regulation of immunological tolerance. Multiple studies have reported an association between high levels of PD-1 expressed on T cell surfaces and exhaustion in lymphocyte populations when challenged by...

Authors: Oestreich KJ, Yoon H, Ahmed R, Boss JM

Aftiphilin and gamma-Synergin are Required for Secretagogue-sensitivity of Weibel-Palade Bodies in Endothelial Cells

Formation of secretory organelles requires the coupling of cargo selection to targeting into the correct exocytic pathway. While the assembly of regulated secretory granules is driven in part by selective aggregation and retention of content, we...

Authors: Lui-Roberts WW, Ferraro F, Nightingale TD, Cutler DF

Long-term transgene expression in mouse neural progenitor cells modified with PhiC31 integrase

Stem cells can potentially be utilized in combined gene/cell therapies for neural diseases. We examined the ability of the non-viral varphiC31 integrase system to promote stable transgene expression in mouse neural progenitor cells (mNPCs). varphiC31...

Authors: Keravala A, Ormerod BK, Palmer TD, Calos MP

SST Peer Reviewed

Protein histidine phosphatase 1 negatively regulates CD4 T cells by inhibiting the K+ channel KCa3.1

The calcium activated K(+) channel KCa3.1 plays an important role in T lymphocyte Ca(2+) signaling by helping to maintain a negative membrane potential, which provides an electrochemical gradient to drive Ca(2+) influx. We previously showed that...

Authors: Srivastava S, Zhdanova O, Di L, Li Z, Albaqumi M, Wulff H, Skolnik EY

G9a and HP1 couple histone and DNA methylation to TNFalpha transcription silencing during endotoxin tolerance

TNFa gene expression is silenced in the endotoxin tolerant phenotype that develops in blood leukocytes after the initial activation phase of severe systemic inflammation or sepsis. The silencing phase can be mimicked in vitro by LPS stimulation. We...

Authors: El Gazzar M, Yoza BK, Chen X, Hu J, Hawkins G, McCall CE

Dramatic caspase-dependent apoptosis in antibody-enhanced dengue virus infection of human mast cells

Severe forms of dengue virus disease, known as dengue hemorrhagic fever and dengue shock syndrome, result from an aberrant immune response involving antibody-dependent enhancement of infection, thrombocytopenia, and a loss of vascular integrity,...

Authors: Brown MG, Huang YY, Marshall JS, King CA, Hoskin DW, Anderson R

Sustained activation of the tyrosine kinase Syk by antigen in mast cells requires local Ca2+ influx through Ca2+ release-activated Ca2+ (CRAC) channels

Mast cell activation involves cross-linking of IgE receptors followed by phosphorylation of the non-receptor tyrosine kinase Syk. This results in activation of the plasma membrane-bound enzyme phospholipase C1, which hydrolyses the minor membrane...

Authors: Ng SW, Dicapite JL, Singaravelu K, Parekh AB

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