Search Results

Constitutive activation of TAK1 by HTLV-1 TAX-dependent overexpression of TAB2 induces activation of JNK-ATF2 but not IKK-NF-kappa B

HTLV-1 Tax oncoprotein induces persistent activation of the transcription factor NF-kappaB and CREB (cAMP-response element-binding protein)/ATF. Transforming growth factor-beta-activated kinase 1 (TAK1) has been shown to play a critical role in these...

Authors: Suzuki S, Singhirunnusorn P, Mori A, Yamaoka S, Kitajima I, Saiki I, Sakurai H

The Loss of Telomerase Activity in Highly Differentiated CD8+CD28-CD27- T Cells Is Associated with Decreased Akt (Ser473) Phosphorylation

The enzyme telomerase is essential for maintaining the replicative capacity of memory T cells. Although CD28 costimulatory signals can up-regulate telomerase activity, human CD8(+) T cells lose CD28 expression after repeated activation. Nevertheless,...

Authors: Plunkett FJ, Franzese O, Finney HM, Fletcher JM, Belaramani LL, Salmon M, Dokal I, Webster D, Lawson...

Human papillomavirus type 31 uses a caveolin 1- and dynamin 2-mediated entry pathway for infection of human keratinocytes

Papillomaviruses are species specific and epitheliotropic DNA viruses that cause tumors in their natural hosts. Certain infections with genital human papillomavirus (HPV) types are causally related to cervical cancer development. Most...

Authors: Smith JL, Campos SK, Ozbun MA

CD4+ T Cells from Simian Immunodeficiency Virus Disease-Resistant Sooty Mangabeys Produce More IL-2 Than Cells from Disease-Susceptible Species: Involvement of p300 and CREB at the Proximal IL-2 Promoter in IL-2 Up-Regulation

IL-2 is an important cytokine required for the physiological function of CD4(+) T cells. Immunological unresponsiveness-anergy- of CD4(+) T cells is characterized by the inability of these cells to synthesize IL-2. Both progressive HIV infection...

Authors: Bostik P, Noble ES, Stephenson ST, Villinger F, Ansari AA

Preferential expression of very late antigen-4 on type 1 CTL cells plays a critical role in trafficking into central nervous system tumors

We have previously shown preferential tumor-homing and therapeutic efficacy of adoptively transferred type 1 CTL (Tc1) when compared with type 2 CTL (Tc2) in mice bearing intracranial ovalbumin-transfected melanoma (M05). Further characterizing the...

Authors: Sasaki K, Zhu X, Vasquez C, Nishimura F, Dusak JE, Huang J, Fujita M, Wesa A, Potter DM, Walker PR,...

SST Peer Reviewed

A 3' enhancer controls snail expression in melanoma cells

A 3' enhancer controls snail expression in melanoma cells. Palmer MB, Majumder P, Green MR, Wade PA, Boss JM. Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA. The snail gene encodes...

Authors: Palmer MB, Majumder P, Green MR, Wade PA, Boss JM

High-pressure freezing provides insights into Weibel-Palade body biogenesis

The Weibel-Palade bodies (WPBs) of endothelial cells play an important role in haemostasis and the initiation of inflammation, yet their biogenesis is poorly understood. Tubulation of their major content protein, von Willebrand factor (VWF), is...

Authors: Zenner HL, Collinson LM, Michaux G, Cutler DF

Breast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane ruffling

Antiestrogens such as tamoxifen are widely used in the clinic to treat estrogen receptor-positive breast tumors. Resistance to tamoxifen can occur either de novo or develop over time in a large proportion of these tumors. Additionally, resistance is...

Authors: Schrecengost RS, Riggins RB, Thomas KS, Guerrero MS, Bouton AH

The transcription factor Runx3 represses the neurotrophin receptor TrkB during lineage commitment of dorsal root ganglion neurons

Runx3, a Runt-domain transcription factor, determines neurotrophin receptor phenotype in dorsal root ganglion (DRG) neurons. Molecular mechanisms by which Runx3 controls distinct neurotrophin receptors are largely unknown. Here, we show that RUNX3...

Authors: Inoue KI, Ito K, Osato M, Lee B, Bae SC, Ito Y

Protein Kinase C Regulates Antigen Receptor-Induced Lytic Granule Polarization in Mouse CD8+ CTL

Lytic granule exocytosis is the major pathway used by CD8(+) CTL to kill virally infected and tumor cells. Despite the obvious importance of this pathway in adaptive T cell immunity, the molecular identity of enzymes involved in the regulation of...

Authors: Ma JS, Monu N, Shen DT, Mecklenbräuker I, Radoja N, Haydar TF, Leitges M, Frey AB, Vukmanovic S,...

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