Search Results

An LRP8 variant is associated with familial and premature coronary artery disease and myocardial infarction

Our previous genomewide linkage scan of 428 nuclear families (GeneQuest) identified a significant genetic susceptibility locus for premature myocardial infarction (MI) on chromosome 1p34-36. We analyzed candidate genes in the locus with a...

Authors: Shen GQ, Li L, Girelli D, Seidelmann SB, Rao S, Fan C, Park JE, Xi Q, Li J, Hu Y, Olivieri O,...

Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation

The second messengers cAMP and cGMP can be degraded by specific members of the phosphodiesterase superfamily or by active efflux transporters, namely the multidrug resistance-associated proteins (MRPs) MRP4 and MRP5. To determine the role of MRP4 and...

Authors: Sassi Y, Lipskaia L, Vandecasteele G, Nikolaev VO, Hatem SN, Cohen Aubart F, Russel FG, Mougenot N,...

Role of Sox-9, ER81 and VE-cadherin in retinoic acid-mediated trans-differentiation of breast cancer cells

Many aspects of development, tumor growth and metastasis depend upon the provision of an adequate vasculature. This can be a result of regulated angiogenesis, recruitment of circulating endothelial progenitors and/or vascular trans-differentiation....

Authors: Endo Y, Deonauth K, Prahalad P, Hoxter B, Zhu Y, Byers SW

RACK1, a new ADAM12 interacting protein; contribution to liver fibrogenesis

ADAM12 belongs to a disintegrin-like and metalloproteinase-containing protein family that possesses multi-domain structures composed of a pro-domain, a metalloprotease, disintegrin-like, cysteine-rich, epidermal growth factor-like and transmembrane...

Authors: Bourd-Boittin K, Le Pabic H, Bonnier D, L'helgoualc'h A, Theret N

Inhibitory role of RhoA on senescence-like growth arrest by a mechanism involving modulation of phosphatase activity

Recently, negative effects of phosphatase in tumorigenesis and metastasis have been suggested in various tumor types. In this study, we showed that RhoA activation modulated phosphatase during senescence-like arrest in human prostate cancer cells....

Authors: Park C, Lee I, Jang JH, Kang WK

IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells

BACKGROUND: The EWS-FLI-1 fusion protein is associated with 85-90% of Ewing's sarcoma family tumors (ESFT), the remaining 10-15% of cases expressing chimeric genes encoding EWS or FUS fused to one of several ets transcription factor family members,...

Authors: Cironi L, Riggi N, Provero P, Wolf N, SuvÜ ML, SuvÜ D, Kindler V, Stamenkovic I

Acetylation of PML is involved in histone deacetylase Inhibitor-mediated apoptosis

The promyelocytic leukemia (PML) protein is a potent tumor suppressor and proapoptotic factor, and is functionally regulated by posttranslational modifications such as phosphorylation, sumoylation, and ubiquitination. Histone deacetylase (HDAC)...

Authors: Hayakawa F, Abe A, Kitabayashi I, Pandolfi PP, Naoe T

Galectin-4 controls intestinal inflammation by selective regulation of peripheral and mucosal T cell apoptosis and cell cycle

Galectin-4 is a carbohydrate-binding protein belonging to the galectin family. Here we provide novel evidence that galectin-4 is selectively expressed and secreted by intestinal epithelial cells and binds potently to activated peripheral and mucosal...

Authors: Paclik D, Danese S, Berndt U, Wiedenmann B, Dignass A, Sturm A

An essential switch in subunit composition of a chromatin remodeling complex during neural development

Mammalian neural stem cells (NSCs) have the capacity to both self-renew and to generate all the neuronal and glial cell-types of the adult nervous system. Global chromatin changes accompany the transition from proliferating NSCs to committed neuronal...

Authors: Lessard J, Wu JI, Ranish JA, Wan M, Winslow MM, Staahl BT, Wu H, Aebersold R, Graef IA, Crabtree GR

Differential regulation and role of interleukin-1 receptor associated kinase-M in innate immunity signaling

Toll-like-receptor mediated signaling is finely regulated by a complex intracellular protein network including the interleukin-1 receptor associate kinases (IRAKs). IRAK-4, 1, and 2 may positively regulate innate immunity signaling through the...

Authors: Su J, Xie Q, Wilson I, Li L

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