Search Results

Epigenetic mechanisms of age-dependent KIR2DL4 expression in T cells

Killer Ig-like receptor (KIR) expression is mostly restricted to NK cells controlling their activation. With increasing age, KIRs are expressed on T cells and contribute to age-related diseases. We examined epigenetic mechanisms that determine the...

Authors: Li G, Weyand CM, Goronzy JJ

The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene

MicroRNAs (miRNAs) are noncoding RNAs that base pair imperfectly to homologous regions in target mRNAs and negatively influence the synthesis of the corresponding proteins. Repression is mediated by a number of mechanisms, one of which is the direct...

Authors: Kong YW, Cannell IG, de Moor CH, Hill K, Garside PG, Hamilton TL, Meijer HA, Dobbyn HC, Stoneley M,...

The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics

To discover new genes involved in axon navigation, we conducted a forward genetic screen for recessive alleles affecting motor neuron pathfinding in GFP reporter mice mutagenized with ENU. In Magellan mutant embryos, motor axons were error prone and...

Authors: Lewcock JW, Genoud N, Lettieri K, Pfaff SL

Retinoic acid utilizes CREB and USF1 in a transcriptional feed-forward loop in order to stimulate MKP1 expression in human immunodeficiency virus-infected podocytes

Nef induced podocyte proliferation and dedifferentiation via MAPK1,2 activation plays a role in HIV nephropathy pathogenesis. All-trans retinoic acid (atRA) reverses the HIV-induced podocyte phenotype by activating cAMP/PKA and inhibiting MAPK1,2....

Authors: Lu TC, Wang Z, Feng X, Chuang P, Fang W, Chen Y, Neves S, Maayan A, Xiong H, Liu Y, Iyengar R,...

SST Peer Reviewed

YY1 Protects Cardiac Myocytes from Pathologic Hypertrophy by Interacting with HDAC5

YY1 is a transcription factor that can repress or activate the transcription of a variety of genes. Here we show that YY1's function as a repressor in cardiac myocytes is tightly dependent on its ability to interact with histone deacetylase 5...

Authors: Sucharov CC, Dockstader K, McKinsey TA

Sez-6 proteins affect dendritic arborization patterns and excitability of cortical pyramidal neurons

Development of appropriate dendritic arbors is crucial for neuronal information transfer. We show, using seizure-related gene 6 (sez-6) null mutant mice, that Sez-6 is required for normal dendritic arborization of cortical neurons. Deep-layer...

Authors: Gunnersen JM, Kim MH, Fuller SJ, De Silva M, Britto JM, Hammond VE, Davies PJ, Petrou S, Faber ES,...

The role of Kalirin9 in p75/NgR-mediated RhoA activation in cerebellar granule neurons

P75 and the Nogo receptor (NgR) form a signaling unit for myelin-inhibitory molecules, with p75 being responsible for RhoA activation. Since p75 lacks the GEF domain, it has remained unclear how p75 activates RhoA. Here, we report that Kalirin 9, a...

Authors: Harrington AW, Li QM, Tep C, Park JB, He Z, Yoon SO

CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation

BACKGROUND: It is generally accepted that CD8+ T cell responses play an important role in control of immunodeficiency virus replication. The association of HLA-B27 and -B57 with control of viremia supports this conclusion. However, specific...

Authors: Loffredo JT, Friedrich TC, LeÜ³n EJ, Stephany JJ, Rodrigues DS, Spencer SP, Bean AT, Beal DR,...

Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments

Here, we report a direct interaction between the beta1 integrin cytoplasmic tail and Rab25, a GTPase that has been linked to tumor aggressiveness and metastasis. Rab25 promotes a mode of migration on 3D matrices that is characterized by the extension...

Authors: Caswell PT, Spence HJ, Parsons M, White DP, Clark K, Cheng KW, Mills GB, Humphries MJ, Messent AJ,...

Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs

Dysregulation of intracellular Ca(2+) homeostasis may underlie amyloid beta peptide (Abeta) toxicity in Alzheimer's Disease (AD) but the mechanism is unknown. In search for this mechanism we found that Abeta(1-42) oligomers, the assembly state...

Authors: Sanz-Blasco S, Valero RA, Rodriguez-Crespo I, Villalobos C, Nunez L

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