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CXCR4-CCR5: a couple modulating T cell functions

Chemokines and their receptors direct leukocyte migration among blood, lymph and tissues. Evidence has recently accumulated that, besides their chemotactic functions, chemokine receptors are highly versatile players that fine tune immune responses....

Authors: Contento RL, Molon B, Boularan C, Pozzan T, Manes S, Marullo S, Viola A

HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation

Eighteen histone deacetylases (HDACs) are present in humans, categorized into two groups: zinc-dependent enzymes (HDAC1-11) and NAD(+)-dependent enzymes (sirtuins 1-7). Among zinc-dependent HDACs, HDAC6 is unique. It has a cytoplasmic localization,...

Authors: Parmigiani RB, Xu WS, Venta-Perez G, Erdjument-Bromage H, Yaneva M, Tempst P, Marks PA

Increased susceptibility of breast cancer cells to stress mediated inhibition of protein synthesis

Protein synthesis is a tightly controlled process, and its deregulation plays an important role in tumorigenesis. Protein synthesis remains poorly understood with very few well-identified validated targets for therapeutic purposes. In this study, we...

Authors: Pervin S, Tran AH, Zekavati S, Fukuto JM, Singh R, Chaudhuri G

The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression

The PI3K/Akt signal pathway plays a key role in tumourigenesis of many cancers and in the subsequent development of drug-resistance. Using the K562 chronic myelogenous leukaemia (CML) cell line and the doxorubicin-resistant derivatives lines KD30 and...

Authors: Hui RC, Gomes AR, Constantinidou D, Costa JR, Karadedou CT, Fernandez de Mattos S, Wymann MP,...

The novel polyamine analogue CGC-11093 enhances the antimyeloma activity of bortezomib

Multiple myeloma (MM) is an incurable plasma cell malignancy. The recent successes of the proteasome inhibitor bortezomib in MM therapy have prompted investigations of its efficacy in combination with other anticancer agents. Polyamines play...

Authors: Carew JS, Nawrocki ST, Reddy VK, Bush D, Rehg JE, Goodwin A, Houghton JA, Casero RA Jr, Marton LJ,...

Vitamin D3 induces autophagy of human myeloid leukemia cells

Vitamin D3 causes potent suppression of various cancer cells; however, significant supraphysiological concentrations of this compound are required for antineoplastic effects. Current combinatorial therapies with vitamin D3 are restricted to...

Authors: Wang J, Lian H, Zhao Y, Kauss MA, Spindel S

upar induces conformational changes in the integrin alphambeta2 headpiece and re-orientation of its transmembrane domains

The GPI-linked uPAR (urokinase-type plasminogen activator receptor) interacts with the heterodimer cell adhesion molecules integrins to modulate cell adhesion and migration. Devoid of a cytoplasmic domain, uPAR triggers intracellular signaling via...

Authors: Tang ML, Vararattanavech A, Tan SM

Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma

Genetic lesions affecting a number of kinases and other elements within the epidermal growth factor receptor (EGFR) signaling pathway have been implicated in the pathogenesis of human non-small-cell lung cancer (NSCLC). We performed mutational...

Authors: Marks JL, Gong Y, Chitale D, Golas B, McLellan MD, Kasai Y, Ding L, Mardis ER, Wilson RK, Solit D,...

Human cytomegalovirus regulates bioactive sphingolipids

Sphingolipids are present in membranes of all eukaryotic cells. Bioactive sphingolipids also function as signaling molecules that regulate cellular processes such as proliferation, migration, and apoptosis. Human cytomegalovirus (HCMV) exploits a...

Authors: Machesky NJ, Zhang G, Raghavan B, Zimmerman P, Kelly SL, Merrill AH Jr, Waldman WJ, Van Brocklyn JR,...

IL-3 induced c-Fos activation is modulated by Gab2-calcineurin interaction

IL-3 regulates cell growth by affecting various processes such as cell death, survival and proliferation. Cues from the external environment are sensed by surface receptors, and complex signaling mechanisms within the cells lead to specific...

Authors: Pyarajan S, Matejovic G, Pratt JC, Baksh S, Burakoff SJ

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