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Dynamic protein associations define two phases of IL-1beta transcriptional activation

IL-1beta is a key proinflammatory cytokine with roles in multiple diseases. Monocytes package the IL-1beta promoter into a "poised architecture" characterized by a histone-free transcription start site and constitutive transcription factor...

Authors: Zhang Y, Saccani S, Shin H, Nikolajczyk BS

Hint2 is expressed in the mitochondria of H295R cells and is involved in steroidogenesis

Hint2 belongs to the superfamily of histidine triad (HIT) hydrolase enzymes. Recently, it has been shown to influence the mitochondria-dependent apoptosis occurring in hepatocytes, but its mechanism of action is still obscure. Here, we demonstrate...

Authors: Lenglet S, Antigny F, Vetterli L, Dufour JF, Rossier MF

IFN-alpha induces transcription of hypoxia-inducible factor-1alpha to inhibit proliferation of human endothelial cells

Expression of hypoxia-inducible factor (HIF)-1alpha, a transcription factor subunit increased by protein stabilization in response to hypoxia, is increased in human endothelial cells (ECs) by IFN-alpha under normoxic conditions. IFN-alpha increases...

Authors: Gerber SA, Pober JS

Histone acetylation and flagellin are essential for Legionella pneumophila-induced cytokine expression

Legionella pneumophila causes severe pneumonia. Acetylation of histones is thought to be an important regulator of gene transcription, but its impact on L. pneumophila-induced expression of proinflammatory cytokines is unknown. L. pneumophila strain...

Authors: Schmeck B, Lorenz J, N'guessan PD, Opitz B, van Laak V, Zahlten J, Slevogt H, Witzenrath M, Flieger...

Ephrins as negative regulators of adult neurogenesis in diverse regions of the central nervous system

In the central nervous system (CNS) of adult mammals, neurogenesis occurs in only two restricted areas, the subgranular zone (SGZ) of the hippocampus and the subventricular zone (SVZ). Isolation of multipotent progenitor cells from other CNS regions...

Authors: Jiao JW, Feldheim DA, Chen DF

A novel mechanism by which thiazolidinediones facilitate the proteasomal degradation of cyclin D1 in cancer cells

This study identifies a novel mechanism by which thiazolidinediones mediate cyclin D1 repression in prostate cancer cells. Based on the finding that the thiazolidinedione family of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists...

Authors: Wei S, Yang HC, Chuang HC, Yang J, Kulp SK, Lu PJ, Lai MD, Chen CS

Requirement of an intermediate gene expression for biphasic ERK1/2 activation in thrombin-stimulated vascular smooth muscle cells

The expression of contractile proteins in vascular smooth muscle (VSM) cells is controlled by still poorly defined mechanisms. A thrombin-inducible expression of smooth muscle-specific a-actin and myosin heavy chain requires transactivation of the...

Authors: Perez Sastre A, Grossmann S, Reusch HP, Schaefer M

Slit-2 induces a tumor suppressive effect by regulating beta -catenin in breast cancer cells

SLIT-2 is considered as a candidate tumor suppressor gene (TSG) since it is frequently inactivated in various cancers due to hypermethylation of its promoter region and allelic loss. However, the exact mechanism of its tumor suppressive effect has...

Authors: Prasad A, Paruchuri V, Preet A, Latif F, Ganju RK

Dynamic interaction between P-bodies and transport ribonucleoprotein particles in dendrites of mature hippocampal neurons

The dendritic localization of mRNAs and their subsequent translation at stimulated synapses contributes to the experience-dependent remodeling of synapses and thereby to the establishment of long-term memory. Localized mRNAs are transported in a...

Authors: Zeitelhofer M, Karra D, Macchi P, Tolino M, Thomas S, Schwarz M, Kiebler M, Dahm R

Multiple Cellular Mechanisms Related to Cyclin A1 in Prostate Cancer Invasion and Metastasis

BACKGROUND: Cyclin A1 is a cell cycle regulator that has been implicated in the progression of prostate cancer. Its role in invasion and metastasis of this disease has not been characterized. METHODS: Immunohistochemistry and cDNA microarray analyses...

Authors: Wegiel B, Bjartell A, Tuomela J, Dizeyi N, Tinzl M, Helczynski L, Nilsson E, Otterbein LE, Harkonen...

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