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Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation

Protein phosphatase 4 catalytic subunit (PP4c) is a PP2A-related protein serine/threonine phosphatase with important functions in a variety of cellular processes, including microtubule (MT) growth/organization, apoptosis, and tumor necrosis factor...

Authors: Toyo-Oka K, Mori D, Yano Y, Shiota M, Iwao H, Goto H, Inagaki M, Hiraiwa N, Muramatsu M,...

The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions

Knockdown of the insulator factor CCCTC binding factor (CTCF), which binds XL9, an intergenic element located between HLA-DRB1 and HLA-DQA1, was found to diminish expression of these genes. The mechanism involved interactions between CTCF and class...

Authors: Majumder P, Gomez JA, Chadwick BP, Boss JM

Lys (K)63-linked polyubiquitination of IRAK-1 is required for IL-1 receptor- and Toll-like receptor-mediated NF-kappaB activation

Stimulation through the IL-1 receptor (IL-1R) and some Toll-like receptors (TLRs) induces ubiquitination of TRAF6 and IRAK-1, signaling components required for NF-kappa B and MAP kinase activation. Here we show that although TRAF6 and IRAK-1 acquired...

Authors: Conze DB, Wu CJ, Thomas JA, Landstrom A, Ashwell JD

Involvement of protective autophagy in TRAIL-resistance of apoptosis defective tumor cells

Targeting TRAIL-Rs with either recombinant TRAIL or agonistic DR4 or DR5-specific antibodies has been considered a promising treatment for cancer, particularly due to the preferential apoptotic susceptibility of tumor cells over normal cells to...

Authors: Han J, Hou W, Goldstein LA, Lu C, Stolz DB, Yin XM, Rabinowich H

Glucocorticoid-related signaling effects in vascular smooth muscle cells

Mineralocorticoid receptor blockade protects from angiotensin II-induced target-organ damage. 11beta-Hydroxysteroid dehydrogenase type 2 protects the mineralocorticoid receptor from activation by glucocorticoids; however, high glucocorticoid...

Authors: Molnar GA, Lindschau C, Dubrovska G, Mertens PR, Kirsch T, Quinkler M, Gollasch M, Wresche S, Luft...

Impaired Bcl3 up-regulation leads to enhanced LPS-induced IL-23p19 gene expression in IL-10-/- mice

Genetic and biochemical analyses show that IL-23p19 plays a central role in mediating bacteria-induced colitis in Interleukin-10 deficient (IL-10-/-) mice. The molecular mechanisms responsible for the dysregulated innate host response leading to...

Authors: Muehlbauer M, Chilton PM, Mitchell TC, Jobin C

Restricted collision coupling of the A2A-receptor revisited: Evidence for physical separation of two signaling cascades

The A(2A)-adenosine receptor is a prototypical G(s) protein-coupled receptor, but stimulates MAP-kinase/erk in a Gs-independent way. The A(2A)-receptor has long been known to undergo restricted collision coupling with G(s); the mechanistic basis for...

Authors: Charalambous C, Gsandtner I, Keuerleber S, Milan-Lobo L, Kudlacek O, Freissmuth M, Zezula J

NFAR-1 and -2 modulate translation and are required for efficient host defense

We report here that the alternatively spliced nuclear factors associated with double-stranded RNA, NFAR-1 (90 kDa) and -2 (110 kDa), are involved in retaining cellular transcripts in intranuclear foci and can regulate the export of mRNA to the...

Authors: Pfeifer I, Elsby R, Fernandez M, Faria PA, Nussenzveig DR, Lossos IS, Fontoura BM, Martin WD, Barber...

Interaction of syntenin-1 and the NG2 proteoglycan in migratory oligodendrocyte precursor cells

Migration of oligodendrocyte precursors along axons is a necessary prerequisite for myelination, but little is known about underlying mechanisms. NG2 is a large membrane proteoglycan implicated in oligodendrocyte migration. Here we show that a PDZ...

Authors: Chatterjee N, Stegmüller J, Schätzle P, Karram K, Koroll M, Werner HB, Nave KA, Trotter J

Cross-recognition of avian H5N1 influenza virus by human cytotoxic T lymphocyte populations directed to human influenza A virus

Since the number of human cases of infection with avian H5N1 influenza viruses is ever increasing, a pandemic outbreak caused by these viruses is feared. Therefore, in addition to virus-specific antibodies, there is considerable interest in immune...

Authors: Kreijtz J, de Mutsert G, van Baalen C, Fouchier R, Osterhaus A, Rimmelzwaan G

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