Search Results

Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) mediated by Th17 and Th1 cells. DNA microarray analysis previously showed that NR4A2, an orphan nuclear receptor, is strongly up-regulated in the peripheral blood T...

Authors: Doi Y, Oki S, Ozawa T, Hohjoh H, Miyake S, Yamamura T

Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).

In this study, we investigated the mechanism of apoptosis induction of obatoclax (GX15-070), a novel Bcl-2 homology domain-3 (BH3) mimetic, in acute myeloid leukemia (AML) cell lines and primary AML samples. Obatoclax inhibited cell growth of HL-60,...

Authors: Konopleva M, Watt J, Contractor R, Tsao T, Harris D, Estrov Z, Bornmann W, Kantarjian H, Viallet J,...

The PCH Family Member Proline-Serine-Threonine Phosphatase-interacting Protein 1 Targets to the Leukocyte Uropod and Regulates Directed Cell Migration

PCH family members have emerged as important regulators of membrane-cytoskeletal interactions. Here we show that PSTPIP1, a PCH family member expressed in hematopoietic cells, regulates the motility of neutrophil-like cells and is a novel component...

Authors: Cooper KM, Bennin DA, Huttenlocher A

STAT5b, c-Src, and EGFR Signaling Play Integral Roles in Estrogen-Stimulated Proliferation of ER-Positive Breast Cancer Cells

17beta-estradiol (E2) acts through the estrogen receptor alpha (ERalpha) to stimulate breast cancer proliferation. Here, we investigated the functional relationship between ERalpha and STAT5b activity in ER+ MCF-7 and T47D human breast cancer cells...

Authors: Fox EM, Bernaciak TM, Wen J, Weaver AM, Shupnik MA, Silva CM

Orexins stimulate steroidogenic acute regulatory (StAR) protein expression through multiple signalling pathways in human adrenal H295R cells

Orexins mediate a variety of physiological processes including feeding behaviour, the circadian pathway and cortisol secretion. Steroidogenesis is regulated by a variety of neuropeptides and one of the key rate-limiting steps is cholesterol transport...

Authors: Ramanjaneya M, Conner AC, Chen J, Stanfield PR, Randeva HS

Epigenetic modification of CCAAT/enhancer binding protein alpha expression in acute myeloid leukemia

Functional loss of CCAAT/enhancer binding protein alpha (C/EBP alpha), a master regulatory transcription factor in the hematopoietic system, can result in a differentiation block in granulopoiesis and thus contribute to leukemic transformation. Here,...

Authors: Hackanson B, Bennett KL, Brena RM, Jiang J, Claus R, Chen SS, Blagitko-Dorfs N, Maharry K, Whitman...

High-level transfection of primary rabbit T lymphocytes

Efficient gene delivery is essential for the assessment of transgene function in untransformed hematopoietic cells. Here, we explored the utility of different non-viral and viral gene delivery techniques for primary T cells from New Zealand White...

Authors: Tervo HM, Allespach I, Keppler OT

SST Peer Reviewed

Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development

B-Raf is the most mutated gene in melanoma; however, the mechanism through which it promotes early melanomas remains uncertain. Most nevi contain activated (V600E)B-Raf but few develop into melanoma, and expression in melanocytes is inhibitory with...

Authors: Cheung M, Sharma A, Madhunapantula SV, Robertson GP

PX-RICS mediates ER-to-Golgi transport of the N-cadherin/beta-catenin complex

Cadherins mediate Ca(2+)-dependent cell-cell adhesion. Efficient export of cadherins from the endoplasmic reticulum (ER) is known to require complex formation with beta-catenin. However, the molecular mechanisms underlying this requirement remain...

Authors: Nakamura T, Hayashi T, Nasu-Nishimura Y, Sakaue F, Morishita Y, Okabe T, Ohwada S, Matsuura K,...

The MODY1 gene HNF4-alpha and a feedback loop control COUP-TFII expression in pancreatic beta cells

Pancreatic islet beta cell differentiation and function are dependent upon a group of transcription factors that maintain the expression of key genes and suppress others. Knockout mice with heterozygous deletion of the Chicken Ovalbumin Upstream...

Authors: Perilhou A, Tourrel-Cuzin C, Zhang P, Kharroubi I, Wang H, Fauveau V, Scott DK, Wollheim CB,...

Data Type

Category

Research Area

Platform

Topic

Species

Characteristic

Format

Origin