Search Results

The somatodendritic endosomal regulator NEEP21 facilitates axonal targeting of L1/NgCAM

We showed previously that axonal accumulation of the cell adhesion molecule L1/neuron-glia cell adhesion molecule (NgCAM) depends on endocytosis (Wisco, D., E.D. Anderson, M.C. Chang, C. Norden, T. Boiko, H. Folsch, and B. Winckler. 2003. J. Cell...

Authors: Yap CC, Wisco D, Kujala P, Lasiecka ZM, Cannon JT, Chang MC, Hirling H, Klumperman J, Winckler B

Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2

Arsenic trioxide (As2O3) is a potent inducer of apoptosis of malignant cells in vitro and in vivo, but the precise mechanisms by which it mediates such effects are not well defined. We provide evidence that As2O3 induces phosphorylation/activation of...

Authors: Dolniak B, Katsoulidis E, Carayol N, Altman JK, Redig AJ, Tallman MS, Ueda T, Watanabe-Fukunaga R,...

Sorting of the neuroendocrine secretory protein secretogranin II into the regulated secretory pathway: Role of amino- and carboxy-terminal alpha-helical domains

Secretogranin II (SgII) belongs to the granin family of prohormones widely distributed in dense-core secretory granules (DCGs) of endocrine, endocrine, and neuronal cells, including sympathoadrenal chromaffin cells. The mechanisms by which secretory...

Authors: Courel M, Vasquez MS, Hook VY, Mahata SK, Taupenot L

Three-dimensional FRET reconstruction microscopy for analysis of dynamic molecular interactions in live cells

Analysis of cellular pathways requires concentration measurements of dynamically interacting molecules within the 3D space of single living cells. Förster Resonance Energy Transfer (FRET) microscopy from widefield, confocal, and potentially from...

Authors: Hoppe AD, Shorte SL, Swanson JA, Heintzmann R

Investigating the regulation of brain specific kinases 1 & 2 by phosphorylation

Brain specific kinases 1 and 2 (BRSK1/2) are AMPK-related kinases that are highly expressed in mammalian forebrain. Studies using transgenic animal models have implicated a role for these kinases in the establishment of neuronal polarity. BRSK1 and...

Authors: Bright NJ, Carling D, Thornton C

Endothelial S100A1 Modulates Vascular Function via Nitric Oxide

S100A1, a Ca(2+)-binding protein of the EF-hand type, is known to modulate sarcoplasmic reticulum Ca(2+) handling in skeletal muscle and cardiomyocytes. Recently, S100A1 has been shown to be expressed in endothelial cells (ECs). Because intracellular...

Authors: Pleger ST, Harris DM, Shan C, Vinge LE, Chuprun JK, Berzins B, Pleger W, Druckman C, Völkers M,...

Filamin A Stabilizes Fc-gamma-RI Surface Expression and Prevents Its Lysosomal Routing

Filamin A, or actin-binding protein 280, is a ubiquitously expressed cytosolic protein that interacts with intracellular domains of multiple receptors to control their subcellular distribution, and signaling capacity. In this study, we document...

Authors: Beekman JM, van der Poel CE, van der Linden JA, van den Berg DL, van den Berghe PV, van de Winkel...

Tumor Cell Killing Mechanisms of Epidermal Growth Factor Receptor (EGFR) Antibodies Are Not Affected by Lung Cancer-Associated EGFR Kinase Mutations

The epidermal growth factor receptor (EGFR) serves as a molecular target for novel cancer therapeutics such as tyrosine kinase inhibitors (TKI) and EGFR Abs. Recently, specific mutations in the EGFR kinase domain of lung cancers were identified,...

Authors: Peipp M, Schneider-Merck T, Dechant M, Beyer T, Lammerts van Bueren JJ, Bleeker WK, Parren PW, van...

XBP-1, a novel HTLV-1 Tax binding protein, activates HTLV-1 basal and Tax-activated transcription

X-box binding protein 1 (XBP-1), a basic leucine zipper transcription factor, plays a key role in cellular unfolded protein response (UPR). There are two XBP-1 isoforms in cells, the spliced XBP-1S and the unspliced XBP-1U. XBP-1U has been shown to...

Authors: Ku SC, Lee J, Lau J, Gurumurthy M, Ng R, Lwa SH, Lee J, Klase Z, Kashanchi F, Chao SH

Comparison of zinc finger nucleases for use in gene targeting in mammalian cells

Homologous recombination is a technique used for performing precise genomic manipulations, and this makes it potentially ideal for gene therapy. The rate of spontaneous homologous recombination in human cells has been too low to be used...

Authors: Pruett-Miller SM, Connelly JP, Maeder ML, Joung JK, Porteus MH

Data Type

Category

Research Area

Platform

Topic

Species

Characteristic

Format

Origin