Search Results

The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2

Ataxin-1 is a neurodegenerative disorder protein whose mutant form causes spinocerebellar ataxia type-1 (SCA1). Evidence suggests that ataxin-1 may function as a transcription repressor. However, neither the importance of this putative...

Authors: Bolger TA, Zhao X, Cohen TJ, Tsai CC, Yao TP

Thioredoxin is required for S-nitrosation of procaspase-3 and the inhibition of apoptosis in Jurkat cells

S-nitrosation is a posttranslational, oxidative addition of NO to cysteine residues of proteins that has been proposed as a cGMP-independent signaling pathway [Hess DT, Matsumoto A, Kim SO, Marshall HE, Stamler JS (2005) Nat Rev Mol Cell Biol...

Authors: Mitchell DA, Morton SU, Fernhoff NB, Marletta MA

Epigenetic silencing of TNFalpha during endotoxin tolerance

Sustained silencing of potentially autotoxic acute proinflammatory genes like tumor necrosis factor alpha (TNFalpha) occurs in circulating leukocytes following the early phase of severe systemic inflammation. Aspects of this gene reprogramming...

Authors: El Gazzar M, Yoza BK, Hu JY, Cousart SL, McCall CE

Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans

Keratan sulfate glycosaminoglycans are among the most abundant carbohydrate components of the cornea and are suggested to play an important role in maintaining corneal extracellular matrix structure. Keratan sulfate carbohydrate chains consist of...

Authors: Kitayama K, Hayashida Y, Nishida K, Akama TO

The oncoprotein NPM-ALK of anaplastic large cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling

Anaplastic large cell lymphomas (ALCL) are highly proliferating tumors that commonly express the AP-1 transcription factor JunB. ALK fusions occur in about 50% of ALCL, and among these 80% have the t(2;5) translocation with NPM-ALK expression. We...

Authors: Staber PB, Vesely P, Haq N, Ott RG, Funato K, Bambach I, Fuchs C, Schauer S, Linkesch W, Hrzenjak A,...

Epstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survival

Many cells latently infected with Epstein-Barr virus (EBV), including certain virus-associated tumors, express latent membrane protein 2A (LMP2A) suggesting an important role for this protein in viral latency and oncogenesis. LMP2A mimics B-cell...

Authors: Mancao C, Hammerschmidt W

Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation

Spinocerebellar ataxia type 7 (SCA7) is a polyglutamine (polyQ) disorder characterized by specific degeneration of cerebellar, brainstem and retinal neurons. Although they share little sequence homology, proteins implicated in CAG trinucleotide...

Authors: Young JE, Gouw L, Propp S, Sopher BL, Taylor J, Lin A, Hermel E, Logvinova A, Chen SF, Chen S,...

Xenografted Adult Human Mesenchymal Stem Cells Provide a Platform for Sustained Biological Pacemaker Function in Canine Heart

Biological pacemaking has been performed with viral vectors, human embryonic stem cells, and adult human mesenchymal stem cells (hMSCs) as delivery systems. Only with human embryonic stem cells are data available regarding stability for >2 to 3...

Authors: Plotnikov AN, Shlapakova I, Szabolcs MJ, Danilo P, Lorell BH, Potapova IA, Lu Z, Rosen AB, Mathias...

Regulation of JNK by MKK-7 in fibroblast-like synoviocytes

OBJECTIVE: JNK regulates matrix metalloproteinase (MMP) gene expression and joint destruction in rheumatoid arthritis (RA). Previous studies demonstrated that the 2 upstream MAPK kinases (MKK-4 and MKK-7) are phosphorylated in RA synovium and form a...

Authors: Inoue T, Hammaker D, Boyle DL, Firestein GS

Annexin 1 cleavage in activated neutrophils: A pivotal role for proteinase 3

Annexin 1 is an anti-inflammatory protein that plays a key role in innate immunity by modulating the activation of several types of cells including neutrophils. Here we have developed a cleavage assay, using tagged annexin 1, and observed marked...

Authors: Vong L, D'Acquisto F, Pederzoli-Ribeil M, Lavagno L, Flower RJ, Witko-Sarsat V, Perretti M

Data Type

Category

Research Area

Platform

Topic

Species

Characteristic

Format

Origin