Search Results

Nitric oxide-p38 MAPK signaling stabilizes mRNA through AU-rich element-dependent and -independent mechanisms

Regulation of mRNA stability by p38 MAPK has been linked to adenosine-uridine-rich elements (AURE) within the 3;-untranslated region (3;UTR) of mRNA. Using microarrays, we previously found that AURE-containing mRNA is over-represented among...

Authors: Wang S, Zhang J, Zhang Y, Kern S, Danner RL

Pepsinogen C proteolytic processing of surfactant protein B

Surfactant protein B is essential to the function of pulmonary surfactant and to lamellar body genesis in alveolar epithelial type 2 cells. The bioactive, mature SP-B is derived from multi-step post-translational proteolysis of a larger proprotein....

Authors: Gerson KD, Foster CD, Zhang P, Zhang Z, Rosenblatt MM, Guttentag SH

SST Peer Reviewed

Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling

Several histone deacetylases (HDAC) are involved in estrogen receptor (ER)-mediated gene transactivation, and HDAC inhibitors have been reported to restore sensitivity to antihormonal therapy. The modulation of ER is the most promising approach to...

Authors: Bicaku E, Marchion DC, Schmitt ML, Münster PN

Thiopental protects human T lymphocytes from apoptosis in vitro via the expression of heat shock protein 70

Barbiturates, which are used for the treatment of intracranial hypertension after severe head injury, have been associated with anti-inflammatory side effects. While all barbiturates inhibit T cell function, only thiobarbiturates markedly reduce the...

Authors: Roesslein M, Schibilsky D, Muller L, Goebel U, Schwer C, Humar M, Schmidt R, Geiger KK, Pahl HL,...

SST Peer Reviewed

Nonvirally Engineered Porcine Adipose Tissue-Derived Stem Cells: Use in Posterior Spinal Fusion

Multiple factors alter intervertebral disc volume, structure, shape, composition, and biomechanical properties, often leading to low back pain. Spinal fusion is frequently performed to treat this problem. We recently published results of our...

Authors: Sheyn D, Pelled G, Zilberman Y, Talasazan F, Frank JM, Gazit D, Gazit Z

SST Peer Reviewed

Etk/BMX, a Btk Family Tyrosine Kinase, and Mal Contribute to the Cross-Talk between MyD88 and FAK Pathways

MyD88 and focal adhesion kinase (FAK) are key adaptors involved in signaling downstream of TLR2, TLR4, and integrin alpha(5)beta(1), linking pathogen-associated molecule detection to the initiation of proinflammatory response. The MyD88 and integrin...

Authors: Semaan N, Alsaleh G, Gottenberg JE, Wachsmann D, Sibilia J

The clustering of GABA(A) receptor subtypes at inhibitory synapses is facilitated via the direct binding of receptor alpha 2 subunits to gephyrin

Classical benzodiazepine sensitive GABA(A) receptor subtypes, the major mediators of fast synaptic inhibition in the brain are heteropentamers that can be assembled from alpha1-3/5, beta1-3, and gamma2 subunits, but how neurons orchestrate their...

Authors: Tretter V, Jacob TC, Mukherjee J, Fritschy JM, Pangalos MN, Moss SJ

MicroRNA-21 Increases Aldosterone Secretion and Proliferation in H295R Human Adrenocortical Cells

MicroRNAs (miRNAs) are endogenous small non-coding RNAs which decrease the expression levels of specific genes by translational repression, sequestration and degradation of their mRNAs. Angiotensin II is an important modulator of adrenal zona...

Authors: Romero DG, Plonczynski MW, Carvajal CA, Gomez-Sanchez EP, Gomez-Sanchez CE

Bifunctional Role of Rev-erb alpha in Adipocyte Differentiation

The nuclear receptor Rev-erbalpha is a potent transcriptional repressor that regulates circadian rhythm and metabolism. Here we demonstrate a dissociation between Rev-erbalpha mRNA and protein levels that profoundly influences adipocyte...

Authors: Wang J, Lazar MA

Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase

Interleukin 1 (IL-1) has been reported to stimulate the polyubiquitination and disappearance of IL-1 receptor-associated kinase 1 (IRAK1) within minutes. It has been thought that the polyubiquitin chains attached to IRAK1 are linked via Lys48 of...

Authors: Windheim M, Stafford M, Peggie M, Cohen P

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Nitric oxide-p38 MAPK signaling stabilizes mRNA through AU-rich element-dependent and -independent mechanisms

Pepsinogen C proteolytic processing of surfactant protein B

Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling

Thiopental protects human T lymphocytes from apoptosis in vitro via the expression of heat shock protein 70

Nonvirally Engineered Porcine Adipose Tissue-Derived Stem Cells: Use in Posterior Spinal Fusion

Etk/BMX, a Btk Family Tyrosine Kinase, and Mal Contribute to the Cross-Talk between MyD88 and FAK Pathways

The clustering of GABA(A) receptor subtypes at inhibitory synapses is facilitated via the direct binding of receptor alpha 2 subunits to gephyrin

MicroRNA-21 Increases Aldosterone Secretion and Proliferation in H295R Human Adrenocortical Cells

Bifunctional Role of Rev-erb alpha in Adipocyte Differentiation

Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase