Search Results

New promoter mutations in the low-density lipoprotein receptor gene which induce familial hypercholesterolaemia phenotype: molecular and functional analysis

Low-density lipoprotein receptor (LDLR) is a cell-surface glycoprotein that mediates specific uptake and catabolism of plasma LDL. Mutations located in the coding region of the LDLR gene affect the structure and function of the protein and cause...

Authors: Francova H, Trbusek M, Zapletalova P, Kuhrova V

Nesprin-2 giant safeguards nuclear envelope architecture in LMNA S143F progeria cells

We demonstrate here that patient dermal fibroblast cells have dysmorphic nuclei containing numerous blebs and lobulations, which progressively accumulate as cells age in culture. The lamin A/C organisation is altered, showing intranuclear and nuclear...

Authors: Kandert S, Lüke Y, Kleinhenz T, Neumann S, Lu W, Jaeger VM, Munck M, Wehnert M, Müller CR, Zhou Z,...

Neuron-derived orphan receptor-1 (NOR-1) is induced by thrombin and mediates vascular endothelial cell growth

BACKGROUND AND AIM: Neuron-derived orphan receptor-1 (NOR-1) is a transcription factor overexpressed in human atherosclerotic plaques that is involved in vascular smooth muscle cell (VSMC) proliferation. The aim of this study was to analyze the role...

Authors: Martorell L, MartÜnez-GonzÜ¡lez J, Crespo J, Calvayrac O, Badimon L

High-throughput transfection and engineering of primary cells and cultured cell lines - an invaluable tool for research as well as drug development

The manipulation of eukaryotic cells by introducing nucleic acids and other substrates using chemical, physical or viral methods is one of the ground-breaking tools in the life sciences. Changes in the molecular equipment of a cell induced by...

Authors: Müller-Hartmann H, Faust N, Kazinski M, Kretzschmar T

PECAM-1 Ligation Negatively Regulates TLR4 Signaling in Macrophages

Uncontrolled TLR4 signaling may induce excessive production of proinflammatory cytokines and lead to harmful inflammation; therefore, negative regulation of TLR4 signaling attracts much attention now. PECAM-1, a member of Ig-ITIM family, can mediate...

Authors: Rui Y, Liu X, Li N, Jiang Y, Chen G, Cao X, Wang J

Cutting Edge: A Transcriptional Repressor and Corepressor Induced by the STAT3-Regulated Anti-Inflammatory Signaling Pathway

IL-10 regulates anti-inflammatory signaling via the activation of STAT3, which in turn controls the induction of a gene expression program whose products execute inhibitory effects on proinflammatory mediator production. In this study we show that...

Authors: El Kasmi KC, Smith AM, Williams L, Neale G, Panopolous A, Watowich SS, Häcker H, Foxwell BM, Murray...

Activation of double-stranded RNA-activated protein kinase by mild impairment of oxidative metabolism in neurons

Thiamine (vitamin B1) deficiency (TD) causes mild and chronic impairment of oxidative metabolism and induces neuronal death in specific brain regions. The mechanisms underlying TD-induced cell death, however, remain unclear. The double-stranded...

Authors: Wang X, Fan Z, Wang B, Luo J, Ke ZJ

Peptide-Mediated Disruption of NFB/NRF Interaction Inhibits IL-8 Gene Activation by IL-1 or Helicobacter pylori

Selective inhibition of proinflammatory chemokines such as IL-8 is an important approach to combat inflammatory and infection diseases. Previous studies suggested that interaction of transcription factors NFkappaB repressing factor (NRF) and NFkappaB...

Authors: Bartels M, Schweda AT, Dreikhausen U, Frank R, Resch K, Beil W, Nourbakhsh M

SST Peer Reviewed

Murine models of chronic lymphocytic leukaemia: role of microRNA-16 in the New Zealand Black mouse model

Mouse models are valuable tools in the study of human chronic lymphocytic leukaemia (CLL). The New Zealand Black (NZB) strain is a naturally occurring model of late-onset CLL characterized by B-cell hyperproliferation and autoimmunity early in life,...

Authors: Scaglione BJ, Salerno E, Balan M, Coffman F, Landgraf P, Abbasi F, Kotenko S, Marti GE, Raveche ES

Sp110 transcription is induced and required by Anaplasma phagocytophilum for infection of human promyelocytic cells

BACKGROUND: The tick-borne intracellular pathogen, Anaplasma phagocytophilum (Rickettsiales: Anaplasmataceae) causes human granulocytic anaplasmosis after infection of polymorphonuclear leucocytes. The human Sp110 gene is a member of the nuclear body...

Authors: de la Fuente J, Manzano-Roman R, Blouin EF, Naranjo V, Kocan KM

SST Peer Reviewed

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