Search Results

Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2

The 200-amino-acid repeat (HIN-200) gene family with the hematopoietic interferon (IFN)-inducible nuclear protein encodes highly homologous proteins involved in cell growth, differentiation, autoimmunity, and tumor suppression. IFIX is the newest...

Authors: Ding Y, Lee JF, Lu H, Lee MH, Yan DH

Related to Testes-Specific, Vespid, and Pathogenesis Protein-1 (RTVP-1) Is Overexpressed in Gliomas and Regulates the Growth, Survival, and Invasion of Glioma Cells

In this study, we examined the expression and functions of related to testes-specific, vespid, and pathogenesis protein 1 (RTVP-1) in glioma cells. RTVP-1 was expressed in high levels in glioblastomas, whereas its expression in low-grade astrocytomas...

Authors: Rosenzweig T, Ziv-Av A, Xiang C, Lu W, Cazacu S, Taler D, Miller CG, Reich R, Shoshan Y, Anikster Y,...

Recombinant Ig-Like Transcript 3-Fc Modulates T Cell Responses via Induction of Th Anergy and Differentiation of CD8+ T Suppressor Cells

The Ig-like transcript (ILT)3 is crucial to the tolerogenic activity acquired by dendritic cells exposed to allospecific T suppressor (Ts) cells. We have explored the immunomodulatory property of the extracellular region of ILT3 using a cytoplasmic...

Authors: Kim-Schulze S, Scotto L, Vlad G, Piazza F, Lin H, Liu Z, Cortesini R, Suciu-Foca N

Production of knockout mice by random or targeted mutagenesis in spermatogonial stem cells

Stem cells represent a unique population of cells with self-renewal capacity. Although they are important therapeutic targets, the genetic manipulation of tissue-specific stem cells has been limited, which complicates the study and practical...

Authors: Kanatsu-Shinohara M, Ikawa M, Takehashi M, Ogonuki N, Miki H, Inoue K, Kazuki Y, Lee J, Toyokuni S,...

SST Peer Reviewed

Loss of Siglec expression on T lymphocytes during human evolution

We report here that human T cells give much stronger proliferative responses to specific activation via the T cell receptor (TCR) than those from chimpanzees, our closest evolutionary relatives. Nonspecific activation using phytohemagglutinin was...

Authors: Nguyen DH, Hurtado-Ziola N, Gagneux P, Varki A

cAMP-dependent protein kinase postsynaptic localization regulated by NMDA receptor activation through translocation of an A-kinase anchoring protein scaffold protein

NMDA receptor-dependent long-term potentiation and long-term depression (LTD) involve changes in AMPA receptor activity and postsynaptic localization that are in part controlled by glutamate receptor 1 (GluR1) subunit phosphorylation. The scaffolding...

Authors: Smith KE, Gibson ES, Dell'Acqua ML

Cellular Responses to Substrate Topography: Role of Myosin II and Focal Adhesion Kinase

Although two-dimensional cultures have been used extensively in cell biological research, most cells in vivo exist in a three-dimensional environment with complex topographical features, which may account for at least part of the striking differences...

Authors: Frey MT, Tsai IY, Russell TP, Hanks SK, Wang YL

The Fat1 cadherin integrates vascular smooth muscle cell growth and migration signals

The significance of cadherin superfamily proteins in vascular smooth muscle cell (VSMC) biology is undefined. Here we describe recent studies of the Fat1 protocadherin. Fat1 expression in VSMCs increases significantly after arterial injury or growth...

Authors: Hou R, Liu L, Anees S, Hiroyasu S, Sibinga NE

Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cells survival and migration

Neuropilin-2 (NRP-2) is a receptor for the Vascular Endothelial Growth Factor (VEGF) and the Semaphorin (Sema) families, two unrelated ligand families involved in angiogenesis and neuronal guidance. NRP-2 binds specifically VEGF-A and VEGF-C, however...

Authors: Favier B, Alam A, Barron P, Bonnin J, Laboudie P, Fons P, Mandron M, Herault JP, Neufeld G, Savi P,...

The SWI/SNF chromatin-remodeling complex is a cofactor for tat transactivation of the HIV promoter

Tat is a critical viral transactivator essential for HIV gene expression. Activation involves binding to an RNA stem-loop structure and recruitment of the pTEFb elongation factor. Tat also induces the remodeling of a single nucleosome in the HIV...

Authors: Mahmoudi T, Parra M, Vries RG, Kauder SE, Verrijzer CP, Ott M, Verdin E

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